Hypoglycemic properties of aqueous bark extract of Ceiba pentandra in streptozotocin-induced diabetic rats

Ladeji, Olusola; Omekarah, Ikechukwu; Solomon, Mariam

doi:10.1016/s0378-8741(02)00321-5

Cited by 51 publications

(32 citation statements)

References 6 publications

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“…It is also possible that treatment with O. gratissimum could be facilitating utilization of glucose by peripheral tissues. This mechanism has been observed in the use of infusion of African mistletoe (Obatomi et al, 1994) and aqueous bark extract of Ceiba pentandra (Ladeji et al, 2003) in the treatment of diabetes mellitus. The mechanism of action was however, not investigated owing to technical reasons.…”

Section: Discussionmentioning

confidence: 77%

Safety and hypoglycaemic properties of aqueous leaf extract of <i>Ocimum gratissimum</i> in streptozotocin induced diabetic rats.

Egesie

Adelaiye²,

Ibu³

et al. 2010

Nig. J. Phys Sci

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Summary:The claim by Nigerian traditional herbal medicine practitioners that Ocimum gratissimum leaves have antidiabetic properties was investigated. Diabetes mellitus was induced with streptozotocin and graded doses of the aqueous leaf extract were administered orally to the experimentally diabetic rats for 28 days. Administration of the aqueous leaf extract caused a statistically significant reduction in plasma glucose level in streptozotocin induced diabetic rats. The extract appeared nontoxic as evidenced by normal serum levels of AST, ALT, ALP, TPT, ALB and bilirubin. These data appear to agree with claimed hypoglycaemic effects of Ocimum gratissimum.

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Section: Discussionmentioning

confidence: 77%

Safety and hypoglycaemic properties of aqueous leaf extract of <i>Ocimum gratissimum</i> in streptozotocin induced diabetic rats.

Egesie

Adelaiye²,

Ibu³

et al. 2010

Nig. J. Phys Sci

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“…This species is also a popular ornamental tree in parks and gardens because of its undemanding soil requirements, achieving satisfactory growth even in dry and sandy soils with poor chemical fertility (Veloso et al, 1997;Cappelatti, Schmitt, 2009). The scientific literature describes various popular medicinal uses of several species of the genus Ceiba (Cartaxo, Souza, Albuquerque, 2010;Scarpa, 2004;Ladeji, Omekarah, Solomon, 2003). There are reports of the popular use of this plant in the northwest region of the state of Rio Grande do Sul for the reduction of serum cholesterol, triglyceride and glucose levels.…”

Section: Introductionmentioning

confidence: 99%

Preliminary in vitro assessment of the potential toxicity and antioxidant activity of Ceiba speciosa (A. St.-Hill) Ravenna (Paineira)

Malheiros

Silva

Hofmann

et al. 2017

Braz. J. Pharm. Sci.

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The bark tea of Ceiba speciosa, a tropical tree of the Malvaceae family, is used in the Northwestern Region of Rio Grande do Sul state, Brazil, to reduce blood cholesterol levels. However, there are no scientific data on the efficacy and safety of this plant. The aim of the present study was to evaluate the in vitro antioxidant and toxic potential of bark extracts of C. speciosa. We performed a preliminary phytochemical analysis by high-performance liquid chromatography-diode array detection (HPLC-DAD) and evaluated the oxidative damage to proteins and lipids, the radical scavenging effect, and genotoxicity of the lyophilized aqueous extract (LAECs) and the precipitate obtained from the raw ethanol extract (Cs1). The phytochemical profile demonstrated the presence of phenolic and flavonoid compounds. The LAECs and Cs1 prevented damage to lipids and proteins at concentrations of 50 and 10 µg/mL. They also showed a scavenging effect on 2,2-diphenyl-1-pricril-hydrazyl (DPPH) radicals in a concentration-dependent manner. Furthermore, no genotoxic effect was observed at concentrations of 10, 5 and 2 µg/mL in the Comet assay. The present study is the first evaluation regarding the characterization of C. speciosa and its safety, and the results demonstrate its antioxidant potential and suggest that its therapeutic use may be relatively safe.Uniterms: Ceiba speciose/phytochemistry. Ceiba speciose/antioxidant activity. Phenolic content. Comet assay. DPPH scavenging capacity. Natural medicine. Safety.

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“…In recent years, there has been renewed interest in plant medicine for the treatment against different diseases (Kameswara Rao et al, 2003;Ladeji et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

et al. 2011

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GOLALIPOUR, M. J.; GHAFARI, S.; LATIFIMOGHADAM, M. H. & KABOLI, S.Alteration of dentate gyrus astrocytes in diabetic rats: Protective role of Urtica dioica. Int. J. Morphol., 29(4):1307-1312, 2011. SUMMARY:Diabetes mellitus can cause astrocytes alterations in the central nervous system. Urtica dioica (Nettle) is among several species listed for their use against diabetes in folk medicine. Therefore, this study was done to evaluate the protective effect of Urtica dioica on astrocytes density of the dentate gyrus in STZ induced diabetic rats. In this experimental study, 21 male albino Wistar rats were randomly allocated equally into normal, diabetic and protective (nettle treated diabetic) groups. Hyperglycemia was induced by streptozotocin (80 mg/kg) in the animals of diabetic and treatment groups. Before induction of diabetes in animals, animals in protective group received hydroalcoholic extract of Urtica dioica (100 mg/kg/BW /day) for five days intraperitoneally. Four weeks after induction of diabetes, animals were sacrificed and coronal sections were taken from the dorsal hippocampal formation of the right cerebral hemispheres and stained with PTAH stain. The area densities of the astrocytes were measured and compared in the three groups (p < 0.05). The number of astrocytes in DG area of controls was 17.72±6.7. The density of astrocytes increased in diabetic (24.26±9.5) in comparison with controls. The density in the nettle treated rats (23.17±5.8) was lower than diabetic rats. This study showed that the administration of U. dioica extract before induction of diabetes can not significantly help compensate for astrocytes in the dentate gyrus of treated rats.

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Hypoglycemic properties of aqueous bark extract of Ceiba pentandra in streptozotocin-induced diabetic rats

Cited by 51 publications

References 6 publications

Safety and hypoglycaemic properties of aqueous leaf extract of <i>Ocimum gratissimum</i> in streptozotocin induced diabetic rats.

Safety and hypoglycaemic properties of aqueous leaf extract of <i>Ocimum gratissimum</i> in streptozotocin induced diabetic rats.

Preliminary in vitro assessment of the potential toxicity and antioxidant activity of Ceiba speciosa (A. St.-Hill) Ravenna (Paineira)

Alteration of Dentate Gyrus Astrocytes in Diabetic Rats: Protective Role of Urtica dioica

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