Hypoglycemic effects of Murraya koenigii on normal and alloxan-diabetic rabbits

Kesari, Achyut Narayan; Gupta, Rajesh Kumar; Watal, Geeta

doi:10.1016/j.jep.2004.11.006

Cited by 162 publications

(92 citation statements)

References 10 publications

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“…The fresh leaves of Murraya koenigii (MKL) are traditionally added to Indian gravy and other vegetables for the delicious taste they impart to various South Indian dishes. Ayurvedic literature as well as recent studies highlights the potential of MKL as an antidiabetic agent (Yadav et al, 2002;Adebajo et al, 2004Adebajo et al, , 2006Kesari et al, 2005). Leaf extract of Murraya koenigii have also been reported to posses antifungal, antineoplastic, nitric oxide scavenging and antioxidant activities (Das et al, 1965;Khan et al, 1996a;Chakrabarty et al, 1997;Khan et al, 1997;Ramsewak, et al, 1999;Tachibana et al, 2001;Baliga et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Nootropic Potential of Murraya koenigii leaves in Rats

Mani¹,

Parle²,

Sengottuvelu³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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SUMMARYMurraya koenigii leaves commonly known as 'curry patta' are routinely added to Indian gravy and vegetarian dishes by south Indian as a favourate condiment. The present study was undertaken to investigate the effects of Murraya koenigii leaves (MKL) on memory in rats. Elevated plus-maze and Hebb-Williams maze served as the exteroceptive behavioral models for testing memory. Diazepam-, scopolamine-and ageing-induced amnesia served as the interoceptive behavioral models. MKL fed orally to various groups of young and aged rats with diet containing 2, 4 and 8% w/w of MKL for 30 days consecutively were investigated. The MKL diets produced a significant dose-dependent improvement in memory scores of young and aged rats and significantly reduced the amnesia induced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Therefore, it would be worthwhile to specifically investigate the therapeutic potential of MKL in the management of dementia patients.

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Section: Introductionmentioning

confidence: 99%

Nootropic Potential of Murraya koenigii leaves in Rats

Mani¹,

Parle²,

Sengottuvelu³

et al. 2008

Oriental Pharmacy and Experimental Medicine

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“…Many synthetic oral hypoglycemic agents, such as Biguanides and sulfonylurea are available along with insulin for the treatment of diabetes mellitus. In the indigenous system of medicine many plants have been claimed to be useful in the treatment of diabetes mellitus (1)(2)(3)(4). Musa paradisiaca (Family: Musaceae) is a perennial tree like herb.…”

Section: Introductionmentioning

confidence: 99%

Assessment of glycemic potential ofMusa paradisiaca stem juice

Singh

Kesari

Kumar

et al. 2007

Indian J Clin Biochem

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The present study reveals the effect of Musa paradisiaca stem juice on blood glucose level (BGL) Address for Correspondence :Dr. Geeta Watal Alternative Therapeutics Unit, Drug Development Division, Medicinal Research Lab, Department of Chemistry, University of Allahabad, Allahabad -211002 E-mail : geetawatal@gmail.com banana fruit pulp to treat ulcers have been explored by a number of investigators (9-12). Since, the flowers and the roots of Musa sapientum showed hypoglycemic effect on normal fasting rabbits (13-14) and the chloroform extract of its flowers showed a reduction in blood glucose, glycosylated hemoglobin and an increase in total haemoglobin (15-16). Therefore the present investigation was under taken to evaluate the effect of M. paradisiaca stem juice on blood glucose level (BGL) of normal and streptozotocin induced diabetic rats in order to assess its glycemic potential. MATERIALS AND METHODS Chemicals :Streptozotocin was purchased from SigmaAldrich Co. USA. BGL (blood glucose level) for FBG (fasting blood glucose) and GTT (glucose tolerance test) studies were assayed using Kits from Bayer Diagnostics, India. One touch (Accu-chek sensor) of Roche Diagnostics, Germany. Solvents from E.Merk. Animals :Male albino wistar rats of body weight about 170-220 gm were used in the experiments. Animals were kept in animal house at an ambient temperature of 25 -30°C and 45-55% relative humidity with a 12h each of dark and light cycle. Animals were fed pellet diet (Golden feed, New Delhi) and water ad-libitum. For experimental purpose the animals were kept fasting overnight but were allowed to free access to water "Principles of laboratory animals care" (NH publication no. 85-23, revised 1985) were followed.

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“…DM is probably the fastest growing metabolic disease in the world and as knowledge of the heterogeneous nature of the disease increases so does the need for more challenging and appropriate therapies. Traditional plant remedies have been used for centuries in the treatment of diabetes (Kesari et al, 2005), but only a few have been scientifically evaluated. Therefore, we have investigated the effect of MEOTS and MEOTR on glycemic control in healthy, glucose loaded and STZ-induced diabetic rats.…”

Section: Discussionmentioning

confidence: 99%

Comparative antidiabetic activity of methanolic extract of Operculina turpethum stem and root against healthy and streptozotocin induced diabetic rats

Pulipaka

Challa²,

Pingili

2012

Int Curr Pharm J

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Diabetes mellitus (DM) consists of a group of syndromes characterized by hyperglycemia. Prevalence of both type 1 and type 2 DM is increasing worldwide, the prevalence of type 2 is rising much more rapidly because of increasing obesity and reduced activity levels as countries become more industrialized. Operculina turpethum, a medicinal plant widely used in the traditional Ayurveda and Siddha systems of medicine for the treatment of diabetes mellitus. The antidiabetic potential of the methanolic extract of O. turpethum stem (MEOTS) and methanolic extract of O. turpethum root (MEOTR) was evaluated in the Streptozotocin (STZ) - induced type 2 diabetic models. The dose 100 mg/kg of MEOTS and MEOTR were administered to normal, glucose loaded and experimental diabetic rats for 21 days. The signi?cantly (p< 0.05) reduction in fasting blood glucose levels were observed in the normal rats at 3 h as well as in the treated diabetic animals at 21 days, thereby justifying the use of the plant in the indigenous system of medicine.DOI: http://dx.doi.org/10.3329/icpj.v1i9.11618 International Current Pharmaceutical Journal 2012, 1(9): 272-278

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Hypoglycemic effects of Murraya koenigii on normal and alloxan-diabetic rabbits

Cited by 162 publications

References 10 publications

Nootropic Potential of Murraya koenigii leaves in Rats

Nootropic Potential of Murraya koenigii leaves in Rats

Assessment of glycemic potential ofMusa paradisiaca stem juice

Comparative antidiabetic activity of methanolic extract of Operculina turpethum stem and root against healthy and streptozotocin induced diabetic rats

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