Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats

Aragão, Danielle M.O.; Guarize, Lyvia; Lanini, Juliana; Costa, Juliana C. Da; García, Raúl; Scio, Elita

doi:10.1016/j.jep.2010.01.008

Cited by 80 publications

(57 citation statements)

References 27 publications

(26 reference statements)

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“…The results showed the elevated levels of these enzymes in diabetic rats, which were diminished in the BNRE treated rats and were in compliance with that of the rats treated with glibenclamide (Table 4). These results indicated the efficacy of the extract to reduce the oxidative stress generated in the hyperglycemic model and this can be positively correlated with the polyphenolic and flavonoid contents in the extract (Aragão et al, 2010).…”

Section: Discussionmentioning

confidence: 66%

Evaluation of antidiabetic, antihyperlipidemic and antioxidant effects of Boehmeria nivea (L.) Gaudich., Urticaceae, root extract in streptozotocin-induced diabetic rats

Sancheti¹,

Bafna²,

Kim³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The potential role of 80% methanolic extract of Boehmeria nivea (L.) Gaudich., Urticaceae, root in the treatment of diabetes, along with its antihyperlipidemic and antioxidant effects, was studied in streptozotocin-induced diabetic male Wistar rats. Preliminary screening of the extract revealed the presence of polyphenolics and fl avonoids. The animal study was conducted with variable doses of 125, 250 and 500 mg/ kg of extract for 21 days in diabetic rats. A signifi cant effect was observed at a dose of 500 mg/kg, which was comparable to the standard drug, glibenclamide. Administration of the extract at a 500 mg/kg dose resulted in a signifi cant reduction of fasting blood glucose, total cholesterol, triglycerides, blood urea, alanine aminotransferase, aspartate aminotransferase, urine sugar and urine ketone levels in diabetic rats in comparison with the diabetic control group. Additionally, this dose signifi cantly increased body weight, hemoglobin, plasma total protein, high density lipoprotein cholesterol, liver glycogen content, superoxide dismutase, reduced glutathione and catalase levels in diabetic rats at the end of 21 days of treatment. Therefore, dietary supplementation with Boehmeria nivea root extract could be benefi cial for correcting hyperglycemia, hyperlipidemia and enhancing the antioxidant defense system. Keywords

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Section: Discussionmentioning

confidence: 66%

Evaluation of antidiabetic, antihyperlipidemic and antioxidant effects of Boehmeria nivea (L.) Gaudich., Urticaceae, root extract in streptozotocin-induced diabetic rats

Sancheti¹,

Bafna²,

Kim³

et al. 2011

Rev. bras. farmacogn.

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“…Several studies are going on throughout the world seeking to identify antioxidant compounds that are pharmacologically potent (Dinesh & Ghosh, 2012;Lönn, et al, 2012;Psaltopoulou et al, 2011;El-barbary et al, 2011;Aragão et al, 2010;Mesquita et al, 2009;Collins, 2005).…”

Section: Resultsmentioning

confidence: 99%

“…Anti-inflammatory and antinoceptive potential (Thomazzia et al, 2010;Silva et al, 2010;Barros et al, 2010) Cardiotonic, sedative and hypoglycemic activities (Aragão et al, 2010;Consolini et al, 2006;) Rheumatism and renal colic (Rodrigues & Carvalho, 2001) Diarrhoea, dysentery, intestinal colic, cystitis, antiviral activity and inhibition of 5-lipoxygenase (Cecílio et al, 2012;Lorenzi & Matos, 2002;Braga et al, 2000;Panizza, 1997) Antidiarrheal, gastro-protective and cicatrising activities (Orsi et al, 2012) Jacaranda species are used for blenorrhagy, skin ulcers, anti-syphilis and anti-gonorrhoea, and anti-inflammatory remedies (Gachet & Schühly, 2009) Struthanthus species are used in parasitosis and skin disorders (Martinez & Barboza, 2010) Wound-healing, anti-inflammatory, anti-ulcerogenic, anti-tyrosinase and Molluscicidal activities (Lopes et. al, 2005;Rebecca et al, 2003;Baurin et al, 2002;Bezerra et al, 2002) Antimalarial, anticancer, hypoglycaemic (Masaba, 2000;Izevbigie et al, 2008) FeCl3 (0.1%).…”

Section: Medicinal Usesmentioning

confidence: 99%

Antioxidant properties of species from the Brazilian cerrado by different assays

Farias

Santos

Paiva

et al. 2013

Rev. bras. plantas med.

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ABSTRACT:The purpose of this study was to screen the antioxidant activity of medicinal plant extracts from the Brazilian cerrado, through other methods than the total phenolic content and its correlation with the antioxidant activity. Ethanolic extracts of ten species were evaluated through three antioxidant assays, in vitro, including 2,2-diphenyl-1-picrylhydrazyl (DPPH), total antioxidant activity and reducing power; and by using the Folin-Ciocalteu method the total phenolic content was determined. Ethanolic extracts of Stryphnodendron obovatum, Cecropia pachystachya and Duguetia furfuraceae showed strong antioxidant activity (IC 50 <5 µg mL -1 ) in the DPPH free radical scavenging assay; the species Vernonia phosphorea, Hymenaea stignocarpa and Jacaranda ulei may also be highlighted. These results were confirmed in the assays of total antioxidant capacity and reducing power. The extracts of S. obovatum and V. phosphorea showed an abundant phenolic content; therefore, the phenolic content may play a role in the antioxidant activity. These two species, traditionally used in Brazil, showed great power in these assay systems and may be a promising source for the development of natural antioxidants and future candidates for phytochemical and pharmacological studies in related diseases. Keywords

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“…Chlorogenic acid and C-glycosylated flavones may explain these activities, but further studies are required to reveal the mechanisms of action. Other possible effects caused by the extract include the enhancement of plasma insulin and an impact on extra-pancreatic mechanisms [43].…”

Section: Cecropia Pachystachyamentioning

confidence: 99%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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■ AbstractDiabetes mellitus is a chronic disease and a leading cause of death in western countries. Despite advancements in the clinical management of the disease, it is not possible to control the late complications of diabetes. The main characteristic feature of diabetes is hyperglycemia, which reflects the deterioration in the use of glucose due to a faulty or poor response to insulin secretion. Alloxan and streptozotocin (STZ) are the chemical tools that are most commonly used to study the disease in rodents. Many plant species have been used in ethnopharmacology or to treat experimentally symptoms of this disease. When evaluated pharmacologically, most of the plants employed as antidiabetic substances have been shown to exhibit hypoglycemic and antihyperglycemic activities, and to contain chemical constituents that may be used as new antidiabetic agents. There are many substances extracted from plants that offer antidiabetic potential, whereas others may result in hypoglycemia as a side effect due to their toxicity, particularly their hepatotoxicity. In this article we present an updated overview of the studies on extracts from medicinal plants, relating the mechanisms of action by which these substances act and the natural principles of antidiabetic activity.

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Hypoglycemic effects of Cecropia pachystachya in normal and alloxan-induced diabetic rats

Cited by 80 publications

References 27 publications

Evaluation of antidiabetic, antihyperlipidemic and antioxidant effects of Boehmeria nivea (L.) Gaudich., Urticaceae, root extract in streptozotocin-induced diabetic rats

Evaluation of antidiabetic, antihyperlipidemic and antioxidant effects of Boehmeria nivea (L.) Gaudich., Urticaceae, root extract in streptozotocin-induced diabetic rats

Antioxidant properties of species from the Brazilian cerrado by different assays

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

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