Hypoglycemic effect of the water extract of Piper sarmentosum in rats

Anti-Diabetic and Antihyperlipidemic Activities of Alternanthera Sessilis in Experimentally Induced Type 2 Diabetes

“…In the other dimension, the antihyperlipidemic potency of EEAS was studied as there is a close correlation between hyperglycemia and hyperlipidemia (Chhanda Mallick et al, 2006) . STZ significantly induced hyperglycemia and upon oral administration of EEAS for 14 days caused a significant (p<0.001) decrease in blood glucose levels which is similar to the significant hypoglycemic effect produced in the diabetic rats upon repeated oral administration of the water extract at a dose of 0.125 g/kg for 7 days (Penchom Peungvicha et al, 1998). Hypercholesterolemia and hypertriglyceridemia are primary factors involved in the development of atherosclerosis and coronary heart diseases which are secondary complications of diabetes.…”

A review of the literature and latest advances in research ofPiper sarmentosum

“…Ethanol extracts of leaves and fruit have not shown any acute oral toxicity, hence, LD 50 of both the extracts is found to be much higher than a limit dose, 2000 mg/kg (Hussain et al, 2010a). Aqueous extracts of the plant are reported to be safe below 10 g/kg dose, whereas a number of deaths have occurred in rats at doses equal to or more than 10 g/kg (Peungvicha et al, 1998). Ridtitid et al (2007) have reported that methanol extracts of leaves at dose 5 g/kg in mice are not having any mortality.…”

Hypolipidemic effects of different angiocarp parts ofAlpinia zerumbet

“…These terpenoids contribute to the major hypoglycemic bioactivity of AZ diets. d-Limonene (Eddouks et al, 2004;Sun, 2007), safrole and β-pinene were shown to possess significant hypoglycemic effect in the streptozotocin-diabetic rats (Peungvicha et al, 1998). Moreover, AZ contains profound polyphenolics, rutin, and quercetin (Agrawal et al, 2010).…”