Hypoglycemic Effect of Smallanthus sonchifolius (Yacon) Extracts on Animals with Streptozotocin-induced Diabetes

Abstract

This study was performed to investigate improvements in diabetes mellitus by extracts of yacon in streptozotocin (STZ)-induced diabetic rats. Fifty rats were divided into a normal group and four experimental groups. STZ (45 mg/kg) was injected intraperitoneally to induce type I diabetes in the four experimental groups. Yacon extracts were administered for 5 weeks. Forty-five ICR mice were also divided into one positive control group and four experimental groups for the oral glucose tolerance test (OGTT) after fed yacon extract. The control group did not eat any yacon extracts, while Group 1 (GI) was fed 125 mg/kg of yacon extracts, Group 2 (GII) was fed 250 mg/kg of yacon extracts, and Group 3 (GIII) was fed 500 mg/kg of yacon extracts. After treatment for 5 weeks, blood glucose in GIII group showed decreased tendency at the 5 week. In OGTT by glucose, the glucose level of yacon treatment group in diabetic rats was significantly decreased compared to the glucose level of the control group, but there was no difference in OGTT by maltose. In ICR mice, the glucose level of the experimental group in OGTT by maltose was significantly decreased compared to the control group. The area of the islets of Langerhans was increased by yacon treatment in a dose-dependent manner on diabetic rats. Insulin concentration of the GIII group was also decreased compared to the control group, while the concentration of fructosamine, total cholesterol, and triglycerides in serum showed no difference. OGTT by glucose or maltose in ICR mice or diabetic rats, area of the Islets of Langerhans, and insulin concentration improved. Yacon treatment may be a useful therapeutic and preventive strategy for diabetes mellitus.

The comparisons of Lycii Radicis Cortex and Corni Fructus water extract effects on streptozotocin-induced diabetes in rats

“…이 중 당질대사 이상을 초래하는 당뇨병은 인슐린의 절대적 또는 상대적 결핍으로 인하여 발생되는 고혈당 상태 및 이에 수반 되는 대사 장애가 장기간 지속되는 상태가 특징이며, 혈관장 애, 망막증, 신증, 신경장애, 감염증 등이 당뇨합병증으로 나 타날 수 있다 1,4) . 당뇨병의 주요 대사 특징은 에너지 대사에 관여하는 포도당을 적극적으로 수용하여 세포대사에 사용하지 못하는 것으로, 세포내로 흡수되지 못한 포도당은 체내에 고 혈당을 야기하게 되고 이 현상은 체내의 지질 중 중성지방과 콜레스테롤 위주로 농도를 증가시킨다 5) .…”