Hypoglycemic Effect ofAloe veraGel on Streptozotocin-Induced Diabetes in Experimental Rats

Abstract

In the present study an attempt has been made to evaluate the presence of hypoglycemic activity in the alcoholic extract of Aloe vera gel. Effects of oral administration of A. vera extract at a concentration of 200 and 300 mg/kg of body weight on (a) normal fasted rats, (b) oral glucose-loaded rats, and (c) streptozotocin-induced diabetic rats have been studied. A. vera extract maintain the glucose homeostasis by controlling the carbohydrate metabolizing enzymes.

Evaluation of Omega-3 on lipid Profile and Biochemical Parameters on Wister Rats

“…and O.A. Abu-Zinadah, 2010;MacLean, C.H., et al, 2006;Massing, M.W., et al, 2001;Rajasekaran, S.K., et al, 2006;Pathak, R.M., et al, 1981;Rajasekaran, S., et al, 2005). It is well documented thatcardiovascular disease induced by hyperglycemia is associated with alterations in serum lipidprofiles (Hussein, H.K.…”

Comparative Proximate Composition and Hypoglycemic Properties of Three Medicinal Plants (Verononia amygdalina, Azadirachta indica and Moringa oleifera).

“…[43] For instance, the amino acid derivative, S-methyl cysteine sulphoxide and S-alkyl cysteine sulphoxide content in Allium cepa (Onion), [44] Allium sativum (Garlic) [45] stimulates insulin secretion, whereas Charantin (a peptide) [46] inhibits hepatic glycogenolysis. Lipid components such as phytosterols [47] stimulate insulin biosynthesis and secretion; β-sitosterol suppresses glucose-6-phosphatase and promotes glycogen biosynthesis with reduced phosphorylase activity. Other phytochemicals such as tannins, [49,50] saponins glycosidic component [38] and pectin materials [51] act by suppressing gluconeogenic enzymes and stimulate insulin secretion.…”

Aloe vera extract reduces 8-oxo-2'-deoxyguanosine levels and improves total antioxidants in streptozotocin-induced diabetic rats

“…(13) Mature, healthy and fresh leaves of Aloe vera having a length of approximately 60 cm were washed with fresh water. The leaves were cut lengthwise into two pieces, then the thick epidermis and the solid gel in the center of the leaf were homogenized in an electric blender.…”

“…(12) Sources of exogenous antioxidant supplements from plants such as aloe (Aloe vera), contain natural components such as phenols, flavonoids, vitamin C and vitamin E, and have been proven to reduce the levels of MDA and increase the antioxidant capacity. (13) Aloe vera extract has an assortment of pharmacological properties which encompasses protection against radiation and antiviral, antibacterial, laxative, antioxidant, antiinflammation, anticancer, antidiabetic, antiallergic, and immunostimulant properties amongst others. (14) Besides, the provision of Aloe vera in diabetic rats showed improvement by increasing the survival of cells of the islets of Langerhans.…”