Hypoglycemic Effect of Calendula arvensis Flowers is Mediated by Digestive Enzyme Inhibition

Abudunia, Abdul-Malik; Marmouzi, Ilias; Kharbach, Mourad; Jemli, Meryem El; Sayah, Karima; Bouyahya, Abdelhakim; Al-kaf, Ali Gamal Ahmed; Alyahawi, Ali; Ansar, Mʼhammed; Bouklouze, Abdelaziz; Faouzi, My El Abbes; Ibrahimi, Azeddine

doi:10.2174/1573407215666190219094407

Cited by 6 publications

(5 citation statements)

References 26 publications

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“…Moreover, the main components isolated; isoquercitrin, isorhamnetin‐3‐ O ‐ β ‐D‐glucopyranoside, 3,5‐di‐ O ‐caffeoylquinic acid and quercetin‐3‐ O ‐(6′′‐acetyl)‐ β ‐D‐glucopyranoside displayed strong inhibition on amylase 39 . Likewise, flower extracts of C arvensis exhibited hypoglycemic effect through inhibition of α‐amylase, α‐glucosidase and ß‐galactosidase, possibly associated with the presence of phenolic compound 40 …”

Section: Resultsmentioning

confidence: 95%

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Chemical composition and biological activities of essential oils from Calendula officinalis L. flowers and leaves

Zengin

Ceylan

et al. 2021

Flavour & Fragrance J

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Calendula officinalis L., commonly known as pot marigold, is a popular ornamental and highly medicinal plant. In fact, it is well recognized for its wide‐ranging therapeutic effects conducive to wound healing and for treating various illnesses. In this study, the essential oils from flowers and leaves of C. officinalis were analysed for their chemical constituents and screened for their in vitro antioxidant and enzyme inhibitory properties. Thirty compounds were found in common in both essential oils, with the sesquiterpene alcohol, α‐cadinol as the most abundant compound (leaf: 32.3% and flower: 31.3%, respectively). Besides, the essential oils were found to possess antioxidant capacity through free radical scavenging and reducing mechanisms (DPPH: 2.94, 1.52 mg trolox equivalent (TE)/g of oil; ABTS: 20.72, 2.86 mg TE/g; CUPRAC: 31.16, 47.98 mg TE/g; FRAP: 24.84, 23.42 mg TE/g; phosphomolybdenum: 4.01, 4.68 mmol TE/g for leaves and flowers essential oils, respectively). Moreover, the essential oils (leaves and flowers, respectively) were found to inhibit all the tested enzymes, namely amylase (0.46, 0.42 mmol acarbose equivalent (ACAE)/g), glucosidase (1.35, 1.31 mmol ACAE/g), acetylcholinesterase (2.48, 2.36 mg galantamine (GALAE)/g) and butyrylcholinesterase (8.13, 8.20 mg GALAE/g) and tyrosinase (47.73, 54.36 mg kojic acid equivalent/g). Molecular docking was also performed revealing the compounds neophytadiene and α‐humulene to show the highest binding affinity with tyrosinase. Therefore, the obtained results demonstrated some appealing activities of C officinalis essential oils as natural pharmacological agents that could be valuable for the potential development of phyto‐formulations against the herein targeted diseases and especially for cosmeceutical applications.

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Section: Resultsmentioning

confidence: 95%

“…39 Likewise, flower extracts of C arvensis exhibited hypoglycemic effect through inhibition of α-amylase, α-glucosidase and ß-galactosidase, possibly associated with the presence of phenolic compound. 40 The browning of vegetables, fruits, and fungi and skin hyperpigmentation in humans are two common undesirable phenomena.…”

Section: Ta B L E 2 (Continued)mentioning

confidence: 99%

Chemical composition and biological activities of essential oils from Calendula officinalis L. flowers and leaves

Zengin

Ceylan

et al. 2021

Flavour & Fragrance J

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“…In vitro investigations showed that some plants were studied in vitro. Indeed, Abudunia et al [ 78 ] have tested the in vitro antidiabetic effects of methanolic, hexane, and aqueous extracts of C. arvensis collected from the region of Khemisset. All tested extracts exhibited enzymatic inhibitory effects on α -amylase, α -glucosidase, and β -glucosidase with some variability.…”

Section: Discussionmentioning

confidence: 99%

Ethnobotanical Survey of Medicinal Plants Used by Traditional Healers to Treat Diabetes in the Taza Region of Morocco

Mrabti

Bouyahya

Mrabti

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Type 2 diabetes is one of the noncommunicable diseases that is becoming a pandemic in Africa. In Morocco, traditional healers have started to use herbal medicines for the treatment of diabetes either individually or in combination with food. The current study aimed to perform an ethnobiological survey of antidiabetic plants use in the Taza region of Morocco. A total of 193 traditional healers were interviewed using a semistructured questionnaire. Data collected were analyzed utilizing the use value (UV), fidelity level (FL), and relative frequency citation (RFC) indices. Forty-six plant species belonging to 28 families were recorded for the treatment of diabetes in the Taza region of Morocco. The most frequently cited plant species are Salvia officinalis, Marrubium vulgare, and Ajuga iva. Lamiaceae, Asteraceae, and Fabaceae were the most reported families. Leaves are the most used part of plants to prepare drugs, the decoction is the preferred mode of preparation, and remedies are often administered orally. Interestingly, Cytisus battandieri, Urginea maritima, Plantago ovata, and Ziziphus jujuba were reported as new medicinal plants used to treat diabetes in the Taza region of Morocco. People in the Taza region still rely on indigenous plants for their basic healthcare needs. Further research should be carried out to validate the antidiabetic effect of the newly reported plant species. This validation can be investigated by the determination of bioactive compounds and evaluation of their in vitro and in vivo antidiabetic effects.

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“…However, recently, some beneficial properties of the C. arvensis are enhancing the need to thoroughly detail its chemical constitution, also with the objective to fully exploit its properties on human and animal health. The hypoglycaemic activity, exerted mainly through enzyme inhibition, of the aqueous and methanolic extracts of C. arvensis flowers have been demonstrated [79]. The inhibitory activity against αamylase, α-glucosidase, and β-galactosidase was ascribed to caffeic acid and its derivatives.…”

Section: Pfrap and Dpph)mentioning

confidence: 99%

Calendula arvensis (Vaill.) L.: A Systematic Plant Analysis of the Polar Extracts from Its Organs by UHPLC-HRMS

Fiorentino

Gravina

Piccolella

et al. 2022

Foods

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Calendula arvensis (Vaill.) L. (field marigold, Asteraceae) is an alimurgic plant, whose flowers and leaves are a common part of local food dishes. The diversity in polar specialized metabolites is herein unraveled, with the aim to further promote and valorize the food use of the plant. To this purpose, following the plant dissection of its organs (florets, fruits, leaves, bracts, stems, and roots), ultrasound assisted maceration has been employed in order to recover phenols and polyphenols. Through an untargeted UHPLC-HR MS (Ultra-High-Performance Liquid Chromatography-High-Resolution Mass Spectrometry) approach, and deeper investigation of the fragmentation patterns of each compound by tandem mass spectrometry, the florets’ constitution in triterpene saponins and flavonol glycosides has been highlighted, whereas hydroxycinnamoyl compounds are mainly in bracts and fruits. The antiradical and reducing capabilities of the organs’ extracts have been assessed, and data acquired have been analyzed by cluster analysis, which allowed bracts and fruits to be observed, despite their negligible food use, as the most active extracts. Chemical and antioxidant data on the diverse organs of field marigold suggest new investigative food and nutraceutical scenarios of this plant, also revalorizing and preserving its traditional uses.

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Hypoglycemic Effect of Calendula arvensis Flowers is Mediated by Digestive Enzyme Inhibition

Cited by 6 publications

References 26 publications

Chemical composition and biological activities of essential oils from Calendula officinalis L. flowers and leaves

Chemical composition and biological activities of essential oils from Calendula officinalis L. flowers and leaves

Ethnobotanical Survey of Medicinal Plants Used by Traditional Healers to Treat Diabetes in the Taza Region of Morocco

Calendula arvensis (Vaill.) L.: A Systematic Plant Analysis of the Polar Extracts from Its Organs by UHPLC-HRMS

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