Hypoglycemic, antidyslipidemic and antioxydant effects of Vitellaria paradoxa barks extract on high-fat diet and streptozotocin-induced type 2 diabetes rats

Abstract

Backgroud Vitellaria paradoxa is a plant belonging to the Sapotaceae family and used in traditional medicine in the treatment of diabetes mellitus. The aim of this work was to evaluate the hypoglycemic, antidyslipidemic and antioxidant effects of V. paradoxa on type 2 diabetic rats. Methods To induce type 2 diabetes mellitus (T2DM), animals were fed a high-fat diet for 4 weeks followed by an intraperitoneal injection of 35 mg/kg of streptozotocin. Diabetic rats were divided into groups and treated for 28 days with V. paradoxa extract (AEVP) at doses of 125, 250 and 500 mg/kg. Body weight, urine volume, food and water consumption were assessed at the start and end of treatment. The glucose tolerance test was performed on the last day of treatment. Blood samples were taken for the assay of biochemical parameters, organs (kidneys and liver) for markers of oxidative stress and pancreas for histological sections. Results AEVP (250 and 500 mg/kg) improved the drop in body weight, polyphagia, polydipsia and polyuria in diabetic rats. AEVP significantly reduced the concentrations of glucose, total cholesterol, triacylglycerol, urea, creatinine, activities of transaminases, and increased the levels of high density lipoprotein cholesterol and serum insulin. AEVP resulted in a decrease in malondialdehyde levels and an increase in catalase and superoxide dismutase activities. An increase in the size and number of islets in the pancreas has also been observed after administration of the extract. Conclusion AEVP has antidiabetic, antidyslipidemic and antioxidant properties, thus confirming its traditional use for the treatment of diabetes. These effects could be due to the presence of phytoconstituents, phenols and flavonoids presents in the plant extract.

Effects of Creatine Supplementation on Histopathological and Biochemical Parameters in the Kidney and Pancreas of Streptozotocin-Induced Diabetic Rats

“…We did observe the reduced blood glucose in creatine-supplemented diabetic animals (DCr group). However, we also observed polydipsia, polyphagia, and decreased body weight in STZ-induced diabetic animals, similar to previous reports [ 90 , 91 , 92 , 93 , 94 ]. Therefore, creatine supplementation in diabetic animals neither attenuated nor aggravated these clinical effects.…”

Evaluation of Antidiabetic Properties of the Leaves Extract of Ficus vallis-choudae Delile in a Model of Type 2 Diabetes Induced by High-Fat Diet and Streptozotocin

“…However, a decrease in TC, TG, LDL-c, AI, and CRI and an increase in HDL-c and CI were shown in the groups treated with AEFV (110, 220, and 440 mg/kg). The work of Miaffo et al [ 46 ] also showed a decrease in the concentration of TC, TG, and LDL-c and a significant increase in the concentration of HDL-c following administration of the aqueous extract of the bark of Vitellaria paradoxa in rats subjected to HFD for 28 days. The hypocholesterolemic effect could be due to the ability of AEFV to inhibit cholesterol biosynthesis in the liver, decreased intestinal absorption of cholesterol, increased LDL receptors, and LDL uptake [ 47 ].…”

Glinus lotoides linn. Seed extract as antidiabetic agent: In vitro and in vivo anti-glucolipotoxicity efficacy in Type-II diabetes mellitus

“…These noteworthy discoveries were concurred with an earlier study on the same plant, which established the plant's efficacy in preventing hypertriglyceridaemia and hypercholesterolaemia. Corroborating its efficacy in averting known treats of diabetes mellitus-related cardiac complications [ 21 , 61 ]. Flavonoids [ 48 ] and anthraquinones [ 62 ] detected in G. lotoides have been attributed to blood TG, TC, LDL-c, and VLDL-c reduction.…”