Hypoglycemic and Vasorelaxant Effect of Passiflora edulis Fruit Peel By-Product

Cabral, Bárbara; Bortolin, Raul Hernandes; Gonçalves, Tays Amanda Felisberto; Maciel, Priscilla Maria Pereira; Arruda, Alinne Villar de; Carvalho, Thaís Gomes de; Abboud, Kahlile Youssef; Alves, Jovelina Samara Ferreira; Cordeiro, Lucimara M.C.; Medeiros, Isac A.; Rezende, Adriana Augusto de; Zucolotto, Silvana Maria

doi:10.1007/s11130-021-00921-8

Cited by 9 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although the primary mechanism through which AFA extract can afford nephroprotection in diabetes remains unknown, previous studies performed by partner research groups have demonstrated the adjuvant effect of P. edulis fruit peel extracts in terms of glycemic control in diabetic rats 14,15 . These previous studies have suggested that polysaccharides, such as pectin and flavonoids (orientin and isoorientin), are associated with the hypoglycemic effect of the extract and, consequently, prevent the emergence of diabetes complications 14,15 . Additionally, studies have revealed that pectin and other soluble fibers present in the extract can create a layer of gel-like substances in the stomach, delaying the absorption of food and reducing serum glucose 35 .…”

Section: Discussionmentioning

confidence: 99%

“…(Passifloraceae), popularly known as the yellow passion fruit. Previous pharmacological studies have reported the P. edulis-mediated anti-diabetic, anti-hypertensive, and anti-inflammatory agent effects, in addition to other effects such as the attenuation of diabetes complications [14][15][16][17] .Herein, we aimed to evaluate the therapeutic effect of P. edulis fruit peel aqueous (AFA) extract adjuvant to insulin as a potential nephroprotective agent against streptozotocin-induced diabetes.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

The nephroprotective action of Passiflora edulis in streptozotocin-induced diabetes

Galdino

Gomes

Júnior

et al. 2022

Sci Rep

View full text Add to dashboard Cite

In the present study, we aimed to evaluate the therapeutic effect of Passiflora edulis fruit peel aqueous (AFA) extract as an adjuvant to insulin to confer nephroprotection against streptozotocin-induced diabetes. Male Wistar rats were divided into four groups based on treatment received for 60 days: diabetic (DB), control (CTL), insulin (INS), and insulin + AFA extract (INS + AFA). mRNA and protein expression levels of podocyte (nephrin, podocin, and WT1) and tubular (megalin) proteins were measured in kidney tissue specimens and urine. Biochemical parameters and kidney histopathology were also examined. Herein, the INS + AFA group showed superior glycemic control, which resulted in the reduction of urinary albumin/creatinine ratio, maintenance of baseline levels of Nphs1, Nphs2, Wt1, and Lrp2 mRNA expression, prevention of protein loss from the kidney tissue into the urinary space, along with the maintenance of glomerular basement membrane thickness, hyalinization, glomerular and tubulointerstitial fibrosis at values approximating those of the CTL group and significantly lower than those in the DB group. Therefore, these results suggest that, as an anti-diabetic agent, the AFA extract adjuvant to insulin could reduce and potentially prevent diabetic kidney disease.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

The nephroprotective action of Passiflora edulis in streptozotocin-induced diabetes

Galdino

Gomes

Júnior

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The peel of Passiflora edulis fruit was reported to contain pectin at a relative molecular weight of 490 kDa, mainly composed of non‐esterified and methyl esterified (1 → 4)‐linked α‐ d ‐galacturonic acid units (Cabral et al, 2021). The antidiabetic properties of the aqueous extract rich in pectin from P. edulis fruit peel were assessed in STZ‐induced diabetic animals at doses of 400 and 600 mg/kg.…”

Section: Polysaccharides' Antidiabetic Action Mechanismsmentioning

confidence: 99%

Polysaccharides (pectin, mucilage, and fructan inulin) and their fermented products: A critical analysis of their biochemical, gut interactions, and biological functions as antidiabetic agents

El‐Nashar,

Taleb,

EL‐Shazly

et al. 2023

Phytotherapy Research

View full text Add to dashboard Cite

Diabetes mellitus is a globally metabolic endocrine syndrome marked by a deficiency of insulin secretion (type‐1 DM) or glucose intolerance arising from insulin response impairment (type‐2 DM) leading to abnormal glucose metabolism. With an increasing interest in natural dietary components for diabetes management, the identification of novel agents witnessed major discoveries. Plant‐derived mucilage, pectin, and inulin are important non‐starch polysaccharides that exhibit effective antidiabetic properties often termed soluble dietary fiber (SDF). SDF affects sugar metabolism through multiple mechanisms affecting glucose absorption and diffusion, modulation of carbohydrate metabolizing enzymes (α‐amylase and α‐glucosidase), ameliorating β‐pancreatic cell dysfunction, and improving insulin release or sensitivity. Certain SDFs inhibit dipeptidyl peptidase‐4 and influence the expression levels of genes related to glucose metabolism. This review is designed to discuss holistically and critically the antidiabetic effects of major SDF and their underlying mechanisms of action. This review should aid drug discovery approaches in developing novel natural antidiabetic drugs from SDF.

show abstract

“…Our research group has been dedicated to studying the polysaccharides obtained from biomass residues from the yellow passion fruit ( Passiflora edulis f. flavicarpa ), an unexplored coproduct of the juice industry. In addition to the already known nutritional value (vitamin B 3 , iron, calcium, and phosphorus) [ 24 ], the consumption of passion fruit offers several beneficial therapeutic effects, including antioxidant, anti-inflammatory [ 25 ], hypoglycemic, and vasorelaxant [ 26 ]. It has also been observed that soluble dietary fibers from passion fruit peel flour presented an antigastric ulcer effect in vivo [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Dietary Polysaccharides from Yellow Passion Fruit Peel on DSS-Induced Colitis in Mice

Bueno¹,

Soley²,

Abboud

et al. 2022

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is a complex inflammatory disorder characterized by chronic and spontaneously relapsing inflammation of the gastrointestinal tract. IBD includes two idiopathic disorders: Crohn’s disease (CD) and ulcerative colitis (UC). In particular, UC causes inflammation and ulceration of the colon and rectum. There is no cure for UC. The pharmacological treatment is aimed at controlling and/or reducing the inflammatory process and promoting disease remission. The present study investigated the possible protective effects of soluble dietary fiber (SDF) isolated from yellow passion fruit peel in the dextran sulfate sodium- (DSS-) induced colitis model in mice, induced by 5% of DSS. The animals were treated with SDF (10, 30, or 100 mg/kg (po)), and the disease activity index was monitored. Colon tissues were collected, measured, and prepared for oxidative stress, inflammation, and histology analysis. SDF improved body weight loss, colon length, and disease activity index and prevented colonic oxidative stress by regulating GSH levels and SOD activity. Furthermore, SDF reduced colonic MPO activity, TNF-α, and IL-1β levels and increased IL-10 and IL-6 levels. As observed by histological analysis, SDF treatment preserved the colonic tissue, the mucus barrier, and reduced inflammatory cell infiltration. Although this is a preliminary study, taken together, our data indicate that SDF may improve the course of DSS-UC. More studies are needed to explore and understand how SDF promotes this protection.

show abstract

Hypoglycemic and Vasorelaxant Effect of Passiflora edulis Fruit Peel By-Product

Cited by 9 publications

References 26 publications

The nephroprotective action of Passiflora edulis in streptozotocin-induced diabetes

The nephroprotective action of Passiflora edulis in streptozotocin-induced diabetes

Polysaccharides (pectin, mucilage, and fructan inulin) and their fermented products: A critical analysis of their biochemical, gut interactions, and biological functions as antidiabetic agents

Protective Effect of Dietary Polysaccharides from Yellow Passion Fruit Peel on DSS-Induced Colitis in Mice

Contact Info

Product

Resources

About