Hypoglycemic and hypolipidemic effects of a polysaccharide from Fructus Corni in streptozotocin-induced diabetic rats

Wang, Dongying; Li, Chenxi; Fan, Wenguo; Yi, Tao; Wei, An-Chi; Ma, Yixin

doi:10.1016/j.ijbiomac.2019.04.160

Cited by 48 publications

(20 citation statements)

References 38 publications

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“…Dietary polysaccharides are natural edible polysaccharides that are essential for our day to day life. Polysaccharides generally extracted from medicinal plants, grains, fruits, vegetables, edible mushroom, and medicinal foods have shown more consideration from investigators due to their low toxicity and numerous pharmacological activities [10,11,12]. They are composed of the monosaccharide unit and linked by glycosidic bonds.…”

Section: Introductionmentioning

confidence: 99%

Anti-Diabetic Effects and Mechanisms of Dietary Polysaccharides

Ganesan

2019

Molecules

116

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Diabetes mellitus is a multifactorial, heterogeneous metabolic disorder, causing various health complications and economic issues, which apparently impacts the human’s life. Currently, commercial diabetic drugs are clinically managed for diabetic treatment that has definite side effects. Dietary polysaccharides mainly derive from natural sources, including medicinal plants, grains, fruits, vegetables, edible mushroom, and medicinal foods, and possess anti-diabetic potential. Hence, this review summarizes the effects of dietary polysaccharides on diabetes and underlying molecular mechanisms related to inflammatory factors, oxidative stress, and diabetes in various animal models. The analysis of literature and appropriate data on anti-diabetic polysaccharide from electronic databases was conducted. In vivo and in vitro trials have revealed that treatment of these polysaccharides has hypoglycemic, hypolipidemic, antioxidant, and anti-inflammatory effects, which enhance pancreatic β-cell mass and alleviates β-cell dysfunction. It enhances insulin signaling pathways through insulin receptors and activates the PI3K/Akt pathway, and eventually modulates ERK/JNK/MAPK pathway. In conclusion, dietary polysaccharides can effectively ameliorate hyperglycemia, hyperlipidemia, low-grade inflammation, and oxidative stress in type 2 diabetes mellitus (T2DM), and, thus, consumption of polysaccharides can be a valuable choice for diabetic control.

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Section: Introductionmentioning

confidence: 99%

Anti-Diabetic Effects and Mechanisms of Dietary Polysaccharides

Ganesan

2019

Molecules

116

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“…Polysaccharides extracted from mushrooms have multiple pharmacological activities and low toxicity and have attracted more attention from researchers (Ganesan and Xu, 2019); assessing polysaccharides with therapeutic effects on diabetic complications has become an important research area (Wang D. et al, 2019). Mycelium zinc polysaccharides from Pleurotus djamor show hepatoprotective and renoprotective effects through the regulation of oxidative stress (OS) and exhibit potential effects on diabetic complications (Zhang et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Adjuvant Therapy With Mushroom Polysaccharides for Diabetic Complications

Jiang

Meng

et al. 2020

Front. Pharmacol.

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Background: Diabetic complications seriously endanger the health of most diabetic patients around the world. Most chemical hypoglycemic agents have adverse effects and are unable to improve the progression of diabetic complications. In recent years, a number of medicinal herbs have become increasingly popular for the treatment of diabetic complications due to their relative safety. Polysaccharides extracted from medicinal herbs with multiple pharmacological activities and low toxicity have been reported to be useful in the treatment of diabetic complications. Methods: Primary studies with keywords including polysaccharide and diabetic complications were retrieved from the Web of Science and NCBI databases and were read and analyzed. Results: Mushroom polysaccharides were proven to have positive effects on diabetic complications. Conclusions: We studied the effects of mushroom polysaccharides on hyperglycemia and as adjuvant therapies for diabetic complications and summarized the applications and limitations of mushroom polysaccharides to better understand their application for the treatment of diabetic complications.

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“…Then, the polysaccharides were extracted from B. ochracea using hot water. The extracting solution was collected, filtered and precipitated by 4 volumes of ethanol at 4 • C for 24 h. Finally, the sample was re-dissolved, deproteinized by repeated freeze-thawing for ten Processes 2020, 8, 341 3 of 12 times [16] and dialyzed against distilled water (exclusion limit 8-14 kDa) for 72 h for further removing the small molecules. The resulting solution was lyophilized and named BOP.…”

Section: Materials Pretreatment and Polysaccharides Extractionmentioning

confidence: 99%

Optimizing the Extraction of Polysaccharides from Bletilla ochracea Schltr. Using Response Surface Methodology (RSM) and Evaluating their Antioxidant Activity

Wang

Chen

et al. 2020

Processes

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Bletilla ochracea Schltr. polysaccharides (BOP) have a similar structure to Bletilla striata (Thunb.) Reichb.f. (Orchidaceae) polysaccharides (BSP). Therefore, BOP can be considered as a substitute for BSP in the food, pharmaceuticals and cosmetics fields. To the best of our knowledge, little information is available regarding the optimization of extraction and antioxidant activity of BOP. In this study, response surface methodology (RSM) was firstly used for optimizing the extraction parameters of BOP. The results suggested that the optimal conditions included a temperature of 82 °C, a duration of 85 min and a liquid/material ratio of 30 mL/g. In these conditions, we received 26.45% ± 0.18% as the experimental yield. In addition, BOP exhibited strong concentration-dependent antioxidant abilities in vitro. The half-maximal effective concentration (EC50) values of BOP against 1,1-diphenyl-2-picrylhydrazyl (DPPH·), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonate) (ABTS+·), hydroxyl (·OH) and superoxide anion (·O2−) radicals and ferrous ions (Fe2+) were determined as 692.16, 224.09, 542.22, 600.53 and 515.70 µg/mL, respectively. In conclusion, our results indicate that BOP can be a potential natural antioxidant, deserving further investigation.

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Hypoglycemic and hypolipidemic effects of a polysaccharide from Fructus Corni in streptozotocin-induced diabetic rats

Cited by 48 publications

References 38 publications

Anti-Diabetic Effects and Mechanisms of Dietary Polysaccharides

Anti-Diabetic Effects and Mechanisms of Dietary Polysaccharides

Adjuvant Therapy With Mushroom Polysaccharides for Diabetic Complications

Optimizing the Extraction of Polysaccharides from Bletilla ochracea Schltr. Using Response Surface Methodology (RSM) and Evaluating their Antioxidant Activity

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