Adjuvant Therapy With Mushroom Polysaccharides for Diabetic Complications

Jiang, Xue; Meng, Weiqi; Li, Lanzhou; Meng, Zhaoli; Wang, Di

doi:10.3389/fphar.2020.00168

Cited by 27 publications

(14 citation statements)

References 122 publications

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“…Carbohydrates are mostly found as polysaccharidesmacromolecules of high molecular weight formed by polymers of monosaccharides such as pentoses and hexoses linked by glycosidic bonds. Recent studies have identified various biological activities of polysaccharides with wide structural diversity from different sources including algae (Xu et al, 2017;Manlusoc et al, 2019;Van Weelden et al, 2019), herbs (Zhang et al, 2013(Zhang et al, , 2015Li et al, 2018a;Maria-Ferreira et al, 2018), fruits (Potterat, 2010;Ahmadi Gavlighi et al, 2018), squids (Zuo et al, 2014a(Zuo et al, , 2015aGu et al, 2017;Chen et al, 2020a), bacteria (Ciszek-Lenda et al, 2011;Jones et al, 2014), and mushrooms (Kothari et al, 2018;Chen et al, 2020b;Jiang et al, 2020).…”

Section: Natural Polysaccharidesmentioning

confidence: 99%

Beneficial Effects of Polysaccharides on the Epithelial Barrier Function in Intestinal Mucositis

Silva¹,

Silveira²,

Bueno³

et al. 2021

Front. Physiol.

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Intestinal mucositis is a clinically relevant side effect of anticancer therapies. It is experienced by 60–100% of patients undergoing treatment with high doses of chemotherapy, radiation therapy, and bone marrow transplantation. Intestinal mucositis can manifest as pain, weight loss, inflammation, diarrhea, rectal bleeding, and infection; affecting normal nutritional intake and intestinal function. It often impacts adherence to anticancer therapy as it frequently limits patient’s ability to tolerate treatment, causing schedule delays, interruptions, or premature discontinuation. In some cases, local and systemic secondary infections are observed, increasing the costs toward medical care and hospitalization. Several strategies for managing mucositis are available which do not always halt this condition. In this context, new therapeutic strategies are under investigation to prevent or treat intestinal mucositis. Polysaccharides from natural resources have recently become promising molecules against intestinal damage due to their ability to promote mucosal healing and their anti-inflammatory actions. These effects are associated with the protection of intestinal mucosa and regulation of microbiota and immune system. This review aims to discuss the recent advances of polysaccharides from natural resources as potential therapies for intestinal mucositis. The source, species, doses, treatment schedules, and mechanisms of action of polysaccharides will be discussed in detail.

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Section: Natural Polysaccharidesmentioning

confidence: 99%

Beneficial Effects of Polysaccharides on the Epithelial Barrier Function in Intestinal Mucositis

Silva¹,

Silveira²,

Bueno³

et al. 2021

Front. Physiol.

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“…Most chemical originated drugs have side effects and are unable to prevent the progression of diabetic complications. Recently several herbal medications have been used to prevent diabetic complications due to their relative safety [116] . Evaluation of dietary polysaccharides were found to have hypoglycemic, hypolipidemic, antioxidant, and anti‐inflammatory effects leading to the enhancement of β‐cells and reducing β‐cell dysfunction.…”

Section: Polysaccharides In Endocrinologymentioning

confidence: 99%

“…They were also able to influence insulin receptors enhancing insulin signaling pathways (PI3K/Akt, ERK/JNK/MAPK) [115] . Polysaccharides derived from mushrooms have been specifically found to positively impact diabetic complications [116] …”

Section: Polysaccharides In Endocrinologymentioning

confidence: 99%

Polysaccharide Chemistry in Drug Delivery, Endocrinology, and Vaccines

Khalid

Asim-ur-Rehman

Ahmed

et al. 2021

Chemistry A European J

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Polysaccharides, due to their outstanding properties, have attracted the attention of researchers, working in the biomedical field and especially of those working in drug delivery. Modified/functionalized polysaccharides further increase the importance for various applications. Delivery of therapeutics for diverse ailments in different endocrine glands and hormones safely, is a focal point of researchers working in the field. Among the routes followed, the transdermal route is preferred due to non‐exposure of active moieties to the harsh gastric environment and first‐pass metabolism. This review starts with the overview of polysaccharides used for the delivery of various therapeutic agents. Advantages of polysaccharides used in the transdermal route are addressed in detail. Types of polysaccharides will be elaborated through examples, and in this context, special emphasis will be on the polysaccharides being used for synthesis of the membranes/films. Techniques employed for their modification to design novel carriers for therapeutics delivery will also be discussed. The review will end with a brief discussion on recent developments and future perspectives for delivery of therapeutic agents, and vaccine development.

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“…Many herbal products contain compounds which have anticoagulant and/or antiplatelet properties, significantly increasing the risk for spontaneous bleeding in these patients [ 35 ]. Another example is medicinal mushrooms, which are popular among oncology patients and whose polysaccharides have been shown to reduce glucose levels and complications of diabetes mellitus [ 36 ]. However, medicinal mushrooms such as reishi ( Ganoderma lucidum ) and maitake ( Grifola fondosa) have been associated with hypoglycemia in patients treated with antidiabetic drugs [ 37 , 38 ].…”

Section: Safety Of Herbal Medicine Use In Oncologymentioning

confidence: 99%

Exploring Herbal Medicine Use during Palliative Cancer Care: The Integrative Physician as a Facilitator of Pharmacist–Patient–Oncologist Communication

Samuels

Ben‐Arye

2020

Pharmaceuticals

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Oncology patients frequently use herbal and other forms of complementary medicine, often without the knowledge of oncologists, pharmacists, and other healthcare professionals responsible for their care. Oncology healthcare professionals may lack the knowledge needed to guide their patients on the safe and effective use of herbal medicinal products, a number of which have potentially harmful effects, which include direct toxicity and negative herb–drug interactions. The current review addresses the prevalence and expectations of oncology patients from herbal medicine, as well as evidence for the beneficial or harmful effects of this practice (potential and actual), especially when the herbal products are used in conjunction with anticancer agents. Models of integrative oncology care are described, in which open and effective communication among oncologists, pharmacists, and integrative physicians on the use of herbal medicine by their patients occurs. This collaboration provides patients with a nonjudgmental and multidisciplinary approach to integrative medicine, echoing their own health-belief models of care during conventional cancer treatments. The role of the integrative physician is to facilitate this process, working with oncologists and pharmacists in the fostering of patient-centered palliative care, while ensuring a safe and effective treatment environment. Case scenario: W. is a 56 year old female artist who was recently diagnosed with localized hormone receptor-positive breast cancer. Following lumpectomy and sentinel node dissection, she is scheduled to begin adjuvant chemotherapy with a regimen which will include adriamycin, cyclophosphamide, and paclitaxel (AC-T protocol). She is worried about developing peripheral neuropathy and its impact on her ability to paint, and she asks about a number of dietary supplements which she heard could prevent this from happening: omega-3, vitamin E, alpha-lipoic acid, and acetyl-l-carnithine. She is concerned, however, that the supplements may negatively interact with her chemotherapy regimen.

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Adjuvant Therapy With Mushroom Polysaccharides for Diabetic Complications

Cited by 27 publications

References 122 publications

Beneficial Effects of Polysaccharides on the Epithelial Barrier Function in Intestinal Mucositis

Beneficial Effects of Polysaccharides on the Epithelial Barrier Function in Intestinal Mucositis

Polysaccharide Chemistry in Drug Delivery, Endocrinology, and Vaccines

Exploring Herbal Medicine Use during Palliative Cancer Care: The Integrative Physician as a Facilitator of Pharmacist–Patient–Oncologist Communication

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