Hypoglycemic and Antioxidant Effects of Cleome Droserifolia ( Samwah ) in Alloxan-Induced Diabetic Rats

Helal, Eman G.E.; Khattab, Alsayeda Mohammed; Aouf, Nouran Abou; Abdallah, Inas Z.A.

doi:10.12816/0009359

Cited by 6 publications

(6 citation statements)

References 20 publications

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“…It should be noted that alloxaninduced diabetic rat model causes clinical and morphological type 1 DM as the majority of scientists state, but considering numerous ways and signs of its action reviewed above and according to the opinion of other authors it may possess signs of both type 1 and type 2 DM, and is an important instrument for testing pharmacological agents 34,71,72 . After all, excess glucose leads to synthesis of fatty acids and facilitates fatty degeneration of the liver with subsequent manifestation of steatosis and cirrhosis, which can be associated with type 2 diabetes on the background of cellular oxidative stress in alloxan action 11,19 .…”

Section: Discussionmentioning

confidence: 99%

“…It should be noted that neither alloxan nor streptozotocin-induced diabetic rat models obtained a considerable assessment of action against the ground of anti-diabetic and anti-neuropathic drugs. Therefore, the modern experimental studies of alloxan-induced DM are aimed at studying of pathological influence of this diabetic model on the system of organs, the forecasting of eventual metabolic changes on the DM's backgrounds, the simultaneous studies of medicines' and medical drugs' impact on the course of these processes [10][11][12][13] .…”

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confidence: 99%

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2019

IJPSR

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Alloxan diabetes mellitus (DM) simulates acute metabolic stress in a different direction, whose starting point is primary lysis of β-cells in the pancreas. Disorders in the system of the major insulin-induced regulatory mechanism occur, initiating imbalance in the system of a living organism generally. Primary changes occur on the level of metabolic ways of the cells of the pancreas and liver: redistribution of mitochondrial and microsomal processes of oxidation with possible synthesis of new isoenzymatic forms of important metabolic enzymes, disturbance of synthesis of regulatory proteins and, as a result, degenerative changes in the cellular structure (lysis, necrosis and apoptosis). Despite the numerous and even contradictory points of view, the theory of cell lysis with the increase of transaminases activity is still predominant. Cytolytic syndrome leads to the destruction of liver cells, the concentration of serum GOT increases dramatically (probably due to the mitochondrial fraction). Under conditions of alloxan-induced diabetic rat model intensification of oxidative stress processes occur provoking changes, which are typical for chronic hepatitis. Alloxan diabetes serves as a classic example of free radical pathology. The next probable link involved in this pathogenesis will be nervous system and general cerebral dysfunction of the body. Numerous disputable data are the evidence of neuroendocrine regulation of the triple system where enzymatic activity or concentration of metabolic indices is the result of many cascade reactions or associated parallel conductors in the system of involved organs, first of all the pancreas and liver. Alloxan diabetes is an example of prior activation of the enzymatic systems. It serves to ensure metabolic changes under conditions of increased generation of hydroxyl radicals and disorders of transmembrane transport both between organelles inside the cells and in the intercellular space. INTRODUCTION: The diabetes mellitus still remains nowadays an urgent issue despite the high social-economic development, which does not prevent Diabetes Mellitus (DM) type 1 and 2.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Untitled

2019

IJPSR

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“…O extrato aquoso de partes aéreas de Cleome droserifolia foi ensaiado in vivo, a fim de verificar a atividade hipoglicemiante em ratos diabéticos induzidos por aloxano (120mg/kg). A administração via oral de 28,5mg/kg do extrato duas vezes ao dia propiciou aumento da produção de insulina e redução da glicemia em ratos diabéticos (HELAL et al, 2015).…”

Section: Atividades Biológicas Do Gênero Cleomeunclassified

Propriedades terapêuticas do gênero cleome, familia cleomaceae

Soares

Silva

Guerra

et al. 2020

BJD

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“…(Cleomacaea) [3] encompasses annual and perennial medicinal herbs or small shrubs [4][5][6][7]. Cleome droserifolia, known by local Bedouin people as Samwah, is employed in traditional medicine in Egypt as a hypoglycemic agent [8,9]. Different researchers analyzed the phytochemical content of C. droserifolia, exploring the existence of flavonoids [10], alkaloids, tannins, saponins, coumarins, catechins, sterols, glucosinolates, and terpenoids [1,9].…”

Section: Introductionmentioning

confidence: 99%

“…Cleome droserifolia, known by local Bedouin people as Samwah, is employed in traditional medicine in Egypt as a hypoglycemic agent [8,9]. Different researchers analyzed the phytochemical content of C. droserifolia, exploring the existence of flavonoids [10], alkaloids, tannins, saponins, coumarins, catechins, sterols, glucosinolates, and terpenoids [1,9]. The essential oil profile of C. droserifolia was also studied, and the main compounds in the essential oil were (Z)-nerolidol and α-cadinol [11].…”

Section: Introductionmentioning

confidence: 99%

Potential Surviving Effect of Cleome droserifolia Extract against Systemic Staphylococcus aureus Infection: Investigation of the Chemical Content of the Plant

Alqahtani,

Negm,

Elekhnawy

et al. 2024

Antibiotics

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The increasing rates of morbidity and mortality owing to bacterial infections, particularly Staphylococcus aureus have necessitated finding solutions to face this issue. Thus, we elucidated the phytochemical constituents and antibacterial potential of Cleome droserifolia extract (CDE). Using LC-ESI-MS/MS, the main phytoconstituents of CDE were explored, which were kaempferol-3,7-O-bis-alpha-L-rhamnoside, isorhamnetin, cyanidin-3-glucoside, kaempferide, kaempferol-3-O-alpha-L-rhamnoside, caffeic acid, isoquercitrin, quinic acid, isocitrate, mannitol, apigenin, acacetin, and naringenin. The CDE exerted an antibacterial action on S. aureus isolates with minimum inhibitory concentrations ranging from 128 to 512 µg/mL. Also, CDE exhibited antibiofilm action using a crystal violet assay. A scanning electron microscope was employed to illuminate the effect of CDE on biofilm formation, and it considerably diminished S. aureus cell number in the biofilm. Moreover, qRT-PCR was performed to study the effect of CDE on biofilm gene expression (cna, fnbA, and icaA). The CDE revealed a downregulating effect on the studied biofilm genes in 43.48% of S. aureus isolates. Regarding the in vivo model, CDE significantly decreased the S. aureus burden in the liver and spleen of CDE-treated mice. Also, it significantly improved the mice’s survival and substantially decreased the inflammatory markers (interleukin one beta and interleukin six) in the studied tissues. Furthermore, CDE has improved the histology and tumor necrosis factor alpha immunohistochemistry in the liver and spleen of the CDE-treated group. Thus, CDE could be considered a promising candidate for future antimicrobial drug discovery studies.

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Hypoglycemic and Antioxidant Effects of Cleome Droserifolia ( Samwah ) in Alloxan-Induced Diabetic Rats

Cited by 6 publications

References 20 publications

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Propriedades terapêuticas do gênero cleome, familia cleomaceae

Potential Surviving Effect of Cleome droserifolia Extract against Systemic Staphylococcus aureus Infection: Investigation of the Chemical Content of the Plant

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