Hypoglycemic Activity of Olive Leaf

Abstract

The hypoglycemic activity of olive leaf was studied. Maximum hypoglycemic activity was obtained from samples collected in the winter months, especially in February. One of the compounds responsible for this activity was oleuropeoside, which showed activity at a dose of 16 mg/kg. This compound also demonstrated antidiabetic activity in animals with alloxan-induced diabetes. The hypoglycemic activity of this compound may result from two mechanisms: (a) potentiation of glucose-induced insulin release, and (b) increased peripheral uptake of glucose.

Antidiabetic and hypolipidemic potential of Rhazya stricta Decne extract and its fractions

“…Oleuropeoside showed maximum hypoglycaemic activity of winter Olive leaf at 16 mg/kg in Alloxan induced diabetetic rats due to potentiation of glucoseinduced insulin release and increased peripheral uptake of glucose (Gonzalez et al, 1992).…”

Phenolic Compounds and Antimicrobial Activity of Olive (Olea europaea L. Cv. Cobrançosa) Leaves

“…This demonstrates the great economic and social importance of this crop and the possible benefits to be derived from utilisation of any of its byproducts [1,2]. Olea europaea L. is widely studied for its alimentary use (the fruits and the oil are important components in the daily diet of a large part of the world's population), whereas the leaves are important for their secondary metabolites such as the secoiridoid compounds oleacein and oleuropein, the former responsible for hypotensive activity [3] and the latter also for hypoglycemic activity [4]. Several reports have shown that olive leaf extract has the capacity to lower blood pressure in animals [5] and increase blood flow in the coronary arteries [6], relieve arrhythmia and prevent intestinal muscle spasms [7].…”

Evaluation of anti-diabetic activty of ethanolic and methanolic extracts of leaves of curcuma inodora against streptozotocin induced diabetic rats

“…of India Acute Toxicity Studies [14,15] Determination of acute toxicity (LD50) The oral acute toxicity of alcoholic and Methanolic extracts were determined in albino Wistar albino rats (150-250 g), maintained under standard husbandry conditions. The animals were fasted 3 hrs prior to the experiment and "Up and Down" procedure of OECD Guidelines No.…”