Hypoglycemic activity of aqueous seed extract of<i>Hunteria umbellata</i>in normal and streptozotocin-induced diabetic rats

Igbe, Ighodaro; Omogbai, Eric K. I.; Ozolua, Raymond I.

doi:10.1080/13880200902973803

Cited by 20 publications

(15 citation statements)

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“…It is known as “Demouain” (in French) and “Abeere” (in Yoruba dialect) (Southwest Nigeria) [11–13]. In Southwest region of Nigeria, water infusion of Hunteria umbellata dried seed is reputably used in the local management of diabetes mellitus and obesity [12, 14]. Hunteria umbellata water seed extract ( HU ) of the plant has been reportedly used to effectively control blood glucose and glycosylated hemoglobin concentration in types 1 and 2 models of drug-induced hyperglycemic Wistar rats [12, 14] with its alkaloid content implicated for the observed biological effect [15].…”

Section: Introductionmentioning

confidence: 99%

“…In Southwest region of Nigeria, water infusion of Hunteria umbellata dried seed is reputably used in the local management of diabetes mellitus and obesity [12, 14]. Hunteria umbellata water seed extract ( HU ) of the plant has been reportedly used to effectively control blood glucose and glycosylated hemoglobin concentration in types 1 and 2 models of drug-induced hyperglycemic Wistar rats [12, 14] with its alkaloid content implicated for the observed biological effect [15]. The same plant seed extract was also reported to possess antiobesity and antihyperlipidemic effects in experimental models of hyperlipidaemia which was mediated via de novo inhibition of cholesterol and triglyceride biosynthesis [16].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Male Fertility-Enhancing Activities of Water Seed Extract of Hunteria umbellata in Wistar Rats

Adeneye

Olagunju

Murtala

2019

Evidence-Based Complementary and Alternative Medicine

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Background. In this study, the male fertility-enhancing activity of 100, 200, and 400 mg/kg/day of Hunteria umbellata water seed extract (HU) in Wistar rats was studied for 60 days. In doing this, effect of repeated doses of HU was studied on the weight gain pattern, gonadosomatic index (GSI), serum follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (TS), prolactin (PRL), and estradiol (ES)} as well as testicular antioxidant status of the treated rats as a way of elucidating the mechanism(s) of action of HU. Method. Thirty-six (36) male Wistar rats were randomly divided into six groups (I-VI) of six rats per group. Group I rats were gavaged with 10 ml/kg/day of distilled water and served as an untreated control; Group II rats were gavaged with 0.3 mg/kg/day of clomiphene in distilled water; Groups III-V rats received 100 mg/kg/day, 200 mg/kg/day, and 400 mg/kg/day of HU, respectively, and Group VI rats received 20 mg/kg/day of Vitamin C all in distilled water. All treatments were for 60 days after which the treated rats were humanely sacrificed. Sera of blood samples were processed for the above stated hormonal profile. Similarly, testicular tissues obtained were processed for semen analysis and complete antioxidant profile of the HU-treated testicles by assaying for superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), glutathione reductase (GSR), glutathione peroxidase (GSH-Px), and Thiobarbituric Reactive Species (TBARS). Results. Prolonged treatments with 100 mg/kg/day, 200 mg/kg/day, and 400 mg/kg/day of HU for 60 days induced dose dependent reductions in weight gain pattern with the most significant (p<0.001) effect recorded with the highest dose of HU. Conversely, significant (p<0.001) increase was recorded for GSI at the same HU dose. Clomiphene and HU also induced significant (p<0.01, p<0.001) dose dependent increases in the total sperm count, %live sperm, but reverse effects on %dead sperm and %abnormal sperm. On the hormonal profile, oral treatment with 100 mg/kg/day, 200 mg/kg/day, and 400 mg/kg/day of the extract induced profound (p<0.05, p<0.01, and p<0.001) dose related increases in the sera TS, LH, and FSH while it caused reverse effect on serum PRL but caused no significant alterations in the serum ES levels. Similarly, oral treatment with vitamin C and 100-400 mg/kg/day of HU induced profound (p<0.05, p<0.01, and p<0.001) increases in the antioxidant enzyme activities. Conclusion. Overall, prolonged oral treatment with 100-400 mg/kg body weight of HU for 60 days significantly improved sperm function which was mediated via enhanced spermatogenesis, steroidogenesis, and antioxidant mechanisms.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of Male Fertility-Enhancing Activities of Water Seed Extract of Hunteria umbellata in Wistar Rats

Adeneye

Olagunju

Murtala

2019

Evidence-Based Complementary and Alternative Medicine

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“…29 However, administration of streptozotocin at 50 mg/kg produced type 2 diabetes, as the rats developed blood glucose levels 3 -4 times higher than normal, failed to gain weight, survived without insulin supplementation and failed to develop ketosis. 23,30 In the present study, the effects of the extract in non-diabetic rats at specific time points are shown in Figure 1. Doses of 500 and 1000 mg/kg produced significant reductions (p < 0.05) in blood glucose levels from the 8 h and 2 h respectively, with maximum effect at 12 h. The effect was sustained up to the 7 th day.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Analysis and Hypoglycaemic Activity of the Methanol Stem Bark Extract of Tabernaemontana pachysiphon Stapf (Apocynaceae)

Uwumarongie¹,

Onwukaeme²,

Igbe³

2017

TJNPR

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“…In diabetes mellitus local treatment, a normal of 2-3 teaspoonful's (10-15 g) of powdered dry seed immersed a glass of high temp water for 20-30 min is prescribed for a grown-up to be taken orally every day [13]. Extracts from Hunteria umbellata have been shown to have antidiabetic, antioxidative and erection stimulating properties [14][15][16]. It also has aphrodiac properties via the modualtion of arginase and nitric oxide activities [17], Its alkaloid fraction has been shown be cardioprotective and hyperlipidemic [18].…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic and antioxidative activities of ethanol seed extract of Hunteria umbellate (Hallier F.) on streptozotocin-induced diabetic rats

Ogunlana

Adetuyi²,

Rotimi

et al. 2021

Clin Phytosci

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Background Diabetes, a global cause of mortality in developing countries is a chronic disorder affecting the metabolism of macromolecules and has been attributed to the defective production and action of insulin characterized by persistent hyperglycemic properties. This global disorder harms organs of the body such as the liver, kidney and spleen. Medicinal plants such as Hunteria umbellate have been shown to possess hypoglycemic, antioxidative and anti-diabetic properties owing to the high concentration of active phytochemical constituents like flavonoids and alkaloids. The present study seeks to evaluate the hypoglycemic activities of ethanolic seed extract of Hunteria umbellate on streptozotocin-induced diabetes rats. Methods Thirty (30) female experimental rats were randomly divided into five groups with six rats per group and were administered streptozotocin (STZ) and Hunteria umbellate as follows. Group 1 served as control and was given only distilled water, group 2 rats were administered 60 mg/kg STZ; Group 3 was administered 60 mg/kg STZ and 100 mg/kg metformin; group 4 rats were administered 60 mg/kg STZ and 800 mg/kg Hunteria umbellate, group 5 rats 60 mg/kg STZ and 400 mg/kg Hunteria umbellate. The fasting blood glucose level of each rat was measured before sacrifice. Rats were then sacrificed 24 h after the last dose of treatment. Results The results showed that Hunteria umbellate significantly reversed STZ-induced increase in fasting blood glucose and increase in body and organs weight of rats. Hunteria umbellate significantly reversed STZ-induced decrease in antioxidant enzyme in liver, kidney and spleen of rats. Hunteria umbellate significantly reversed STZ-induced increase in oxidative stress markers in liver, kidney and spleen of rats. Conclusion Collectively, our results provide convincing information that inhibition of oxidative stress and regulation of blood glucose level are major mechanisms through which Hunteria umbellate protects against streptozotocin-induced diabketes rats.

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Hypoglycemic activity of aqueous seed extract ofHunteria umbellatain normal and streptozotocin-induced diabetic rats

Cited by 20 publications

References 11 publications

Evaluation of Male Fertility-Enhancing Activities of Water Seed Extract of Hunteria umbellata in Wistar Rats

Evaluation of Male Fertility-Enhancing Activities of Water Seed Extract of Hunteria umbellata in Wistar Rats

Phytochemical Analysis and Hypoglycaemic Activity of the Methanol Stem Bark Extract of Tabernaemontana pachysiphon Stapf (Apocynaceae)

Hypoglycemic and antioxidative activities of ethanol seed extract of Hunteria umbellate (Hallier F.) on streptozotocin-induced diabetic rats

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