Phytochemical Analysis and Hypoglycaemic Activity of the Methanol Stem Bark Extract of Tabernaemontana pachysiphon Stapf (Apocynaceae)

Uwumarongie, O H; Onwukaeme, N. D.; Igbe, Ighodaro

doi:10.26538/tjnpr/v1i5.8

Cited by 1 publication

(1 citation statement)

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“…A number of compounds bearing the indole moiety have been described to own affinity toward different serotonin receptors [31] Neurotransmitters like serotonin have structure similar to indole alkaloids and this has led to the prediction of neurological activity of indoles [43]. n-Hexadecaneoic acid with undecanoic acid found in Rauwolfia vomitoria has also being reported by [44] in a GC-MS metabolite profiling of the methanol stem bark extract of T. pachysiphon (Apocyanacae) to be the most predominant metabolites with n -Hexadecanoic acid (27.49%), Oleic acid (14.60%) and Octadecanoic acid (6.38%). n-Hexadecaneoic acid with undecanoic acid have been reported to be an acidifier, acidulant, increase aromatic acid decarboxylase activity, inhibitor of uric acid production and arachidonic acid [45].…”

Section: Resultsmentioning

confidence: 99%

GC-MS Analysis of the Rauwolfia vomitoria Ethanol Extracts

Asoro

Ebuehi

Igwo-Ezikpe

2021

EJMP

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Bioactive compounds are the frontline potent agents in both nutraceuticals and pharmaceutical industries. The bioactive compounds are gaining much importance for their ability in enhancing resistance to various diseases and to improve the health of people both by traditional and modern ways of administrations. R. vomitoria is one of the medicinal plants used traditionally to manage hypertension, diabetes and mental disorder. This present study sought to characterize the bioactive components of R. vomitoria leaf and root ethanol extracts using Gas-Chromatography-Mass Spectrophotometry (GC-MS). The results of the GC-MS analysis provide different peaks indicating the presence of 22 phytochemicals in the plant leaf and 16 phytochemicals in the root. The major bioactive compounds in the leaf were squalene (18.69%), phytol (16.47%), n-hexadecanoic acid (15.68%), 7-tetradecenal, (Z) (12.90%), 9,12,15-octadecatrienoic acid, ethyl ester, (Z,Z)-, (9.56%) and others, while the roots contains; cis-vaccenic acid (32.13%), n-hexadecanoic acid (15.41%), (E)-9-octadecenoic acid ethyl ester (9.83), cyclohexanecarbonitrile 1-(-4- chlorophenyl (9.45%), 8H-azeceno[5,4-b] indol-8-one, 5-ethylidene (7.66%) and other minor compounds. Pharmacological activities of these compounds indicated that the compounds present in the leaf of the plant can be used as a crude drug which could be developed into a novel drug. Some of these compounds have antimicrobial, antioxidant, hepatoprotective, hypocholesterolemic as well as cancer preventive activities amongst others. The findings suggest that there is an indication that both R. vomitoria leaves and roots contain potent bioactive compounds that may be linked to its beneficial effects on health, with the leaf taking the lead. It is therefore recommended as a plant of phytopharmaceutical significance.

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Section: Resultsmentioning

confidence: 99%