Hypoglycemic activity of Abutilon indicum leaf extracts in rats

Seetharam, Y. N.; Chalageri, Gururaj; Setty, S. Ramachandra; Bheemachar,

doi:10.1016/s0367-326x(02)00015-1

Cited by 45 publications

(28 citation statements)

References 3 publications

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“…37 Glycosides could be stimulated insulin secretion as well. 25 These chemical substances in plants may be responsible for the anti-diabetic effects were observed in the study. Moreover, the blood biochemical data were found that improve some renal and liver function such as BUN, AST, ALT and ALP.…”

Section: Discussionmentioning

confidence: 66%

“…22 The components contained the natural substances such as amino acids, aliphatic compounds, sugars, polyphenols, flavonoids, alkaloids and glycosides. 23 The plant is also reported to possess analgesic, 24 hypoglycemic, [25][26][27][28][29] hepatoprotective 30 and antibacterial activity. 31 With respect to its traditional use in Thai traditional recipe, A. indicum and M. pudica should contain an active ingredient against diabetes and was believed to reduce some symptoms of diabetic complications.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats

Konsue¹,

Talubmook²

2018

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Context:Abutilon indicum and Mimosa pudica were a folklore recipe in Northeastern of Thailand. The recipe was reported that claim to diabetic treatment. Aims: The studies were evaluated to hypoglycemic effect, serum insulin secretion and blood biochemistry in streptozotocin (STZ)-induced diabetic rats. Materials and Methods: The recipe were composed of whole plants from A. indicum and M. Pudica (1:1 w/w) powder. The pound plants were macerated with aqueous (AMA), hydro-ethanol (AMHE) and 80% ethanol (AME) to crude extracts. The AMA, AMHE and AME at the doses of 125, 250 and 500 mg/kg body weight (b.w.) were administered orally daily in diabetic rats during eight weeks. Fasting blood glucose levels (FBG) were measured at weekly. The serum insulin levels and blood biochemical data including blood urea nitrogen (BUN), creatinine (CREA), total protein (TP), albumin (Alb), serum aspartate aminotransferase (AST), serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) were estimated at the end of experiment. Results: All doses of the extracts were showed significantly (p<0.05) decreasing percent age of FBG in diabetic rats. Especially, AME 125 mg/ kg b.w. was showed more potent significantly (p<0.05) decreasing percentage of FBG at week of 2, 5, 7 and 8. The serum insulin levels of all doses administered with the extracts were significantly (p< 0.05) higher than diabetic control group. On the other hand, all doses of the extracts were significantly (p< 0.05) decreasing ALT and ALP lower than diabetic control group. While, AMA and AMHE at the doses of 250 and 500 mg/kg b.w. were increased HDL, but decreased TC, TG and LDL. Conclusion: The study was proved to diabetic treatment and improvement of diabetic stage and blood biochemical parameters. In addition, the experiment was confirmed to folklore traditional use.

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Section: Discussionmentioning

confidence: 66%

Section: Introductionmentioning

confidence: 99%

Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats

Konsue¹,

Talubmook²

2018

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“…24,25 Diabetes is associated with alterations in the plasma lipid and lipoprotein profile, with an increased risk of coronary heart disease. 26 Our data show that the level of HDL was increased, but levels of TC, TG, LDL in the diabetic rats were decreased.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemic and Hypolipidemic Activities of Ethanolic Extract from Mimosa pudica L. in Normal and Streptozotocin-Induced Diabetic Rats

Yupparach¹,

Konsue²

2017

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Context:Mimosa pudica L. its unique property to collapse when touched and opens up. Aims: To evaluate hypoglycemic and hypolipidemic activities of 80% ethanolic extract from whole plant of Mimosa pudica L. (MPE) by measuring fasting blood glucose in normal and streptozotocin (STZ)-induced diabetic rats treated with MPE. Materials and Methods: An eight-week study using MPE was performed in normal and streptozotocin (STZ)-induced diabetic rats. Hypoglycemic activities in normal and STZ-induced diabetic rats and oral glucose tolerance test (OGTT) and biochemical data include total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) of MPE were compared with glibenclamide, a standard anti-diabetic drug. Results: OGTT showed that MPE did not decrease blood glucose both in normal and STZ-induced diabetic rats comparable to controls and glibenclamide treated rats. Moreover, MPE did not affect FBG in the normal rats. However, it significantly (p<0.05) decreased FBG in the diabetic rats while MPE increased HDL and decreased TC, TG and LDL in the diabetic rats. Conclusions: The results from this study confirmed the traditional use of Mimosa pudica L. for the treatment of diabetes mellitus.

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“…There are various herbs which are used for the treatment of diabetes mellitus. Large number of plants have been explored for their antidiabetic potential, for e.g Cyompsis tetragonoloba [5], Cichorum intybus [6], Ficus carica [7], Picralima nitida [8], Phyllanthus amarus [9], Abutilon indicum [10], Clausena Anisata, [11], Alpinia galangal [12] etc.…”

Section: Introduction:-mentioning

confidence: 99%

Antidiabetic Effect of Some Medicinal Plants Bark, Leaf and Seed Extracts in Streptozotocin Induced Diabetic Rats.

Razak¹,

Elyas²,

Thomas³

et al. 2016

IJAR

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Hypoglycemic activity of Abutilon indicum leaf extracts in rats

Cited by 45 publications

References 3 publications

Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats

Effect of Thai Folklore Recipe from Abutilon indicum and Mimosa pudica in Streptozotocin-Induced Diabetic Rats

Hypoglycemic and Hypolipidemic Activities of Ethanolic Extract from Mimosa pudica L. in Normal and Streptozotocin-Induced Diabetic Rats

Antidiabetic Effect of Some Medicinal Plants Bark, Leaf and Seed Extracts in Streptozotocin Induced Diabetic Rats.

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