Hypoglycemic and Hypolipidemic Activities of Ethanolic Extract from Mimosa pudica L. in Normal and Streptozotocin-Induced Diabetic Rats

Abstract

Context:Mimosa pudica L. its unique property to collapse when touched and opens up. Aims: To evaluate hypoglycemic and hypolipidemic activities of 80% ethanolic extract from whole plant of Mimosa pudica L. (MPE) by measuring fasting blood glucose in normal and streptozotocin (STZ)-induced diabetic rats treated with MPE. Materials and Methods: An eight-week study using MPE was performed in normal and streptozotocin (STZ)-induced diabetic rats. Hypoglycemic activities in normal and STZ-induced diabetic rats and oral glucose tolerance test (OGTT) and biochemical data include total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) of MPE were compared with glibenclamide, a standard anti-diabetic drug. Results: OGTT showed that MPE did not decrease blood glucose both in normal and STZ-induced diabetic rats comparable to controls and glibenclamide treated rats. Moreover, MPE did not affect FBG in the normal rats. However, it significantly (p<0.05) decreased FBG in the diabetic rats while MPE increased HDL and decreased TC, TG and LDL in the diabetic rats. Conclusions: The results from this study confirmed the traditional use of Mimosa pudica L. for the treatment of diabetes mellitus.

Hypoglycaemic and Hypolipidemic Properties of Ethyl Acetate Fraction of &lt;i&gt;P. americana&lt;/i&gt; Leaf in Alloxan-Induced Diabetic Rats

“…Diabetesinduced hyperlipidemia is attributable to excess mobilization of fat from the adipose due to the under utilization of glucose [44]. According to studies by [45,46,47] it was shown that chronic insulin deficiency as observed in alloxan-induced hyperglycaemia in experimental animals is associated with diminished levels of LDL receptors, blood cholesterol and triglyceride [48,49]. This results to an increase in LDL particles and consequently increases serum level of LDL.…”

A Review on the Pharmacological and Traditional Properties of Mimosa Pudica

“…The experiment lasted for eight weeks, blood serum was collected, and biochemical parameters were analysed. The group which received M. pudica extracts tend to have a high level of HDL and TG, TC and LDL decrease which shows the hypolipidemic potential of M. pudica [34].…”

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“…Ethanolic plant extracts were reported to reduce the blood glucose level in streptozotocin-induced diabetic rats. This indicates that Mimosa pudica has a significant antidiabetic activity 20 . Chloroform and methanolic root, shoot extracts showed wound healing activity when applied topically with a significant increase in the hydroxyproline content, tear strength and dry weight of the granulation tissue in the wound incision pattern 21 -23 .…”