Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks

Lu, Zhaolian; Jia, Qi; Wang, Rui; Wu, Xuli; Wu, Yingchun; Huang, Chun; Li, Yiming

doi:10.1016/j.phymed.2010.08.008

Cited by 86 publications

(68 citation statements)

References 24 publications

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“…Also, cinnamon treatment significantly increased the consumption of extracellular glucose in insulinresistant HepG2 cells and normal HepG2 cells compared with controls. These results suggest that the extracts of both cinnamon species exhibit hypoglycemic activities, and may improve insulin sensitivity in T2D [45].…”

Section: Cinnamomum Cassia and C Japonicamentioning

confidence: 66%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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■ AbstractDiabetes mellitus is a chronic disease and a leading cause of death in western countries. Despite advancements in the clinical management of the disease, it is not possible to control the late complications of diabetes. The main characteristic feature of diabetes is hyperglycemia, which reflects the deterioration in the use of glucose due to a faulty or poor response to insulin secretion. Alloxan and streptozotocin (STZ) are the chemical tools that are most commonly used to study the disease in rodents. Many plant species have been used in ethnopharmacology or to treat experimentally symptoms of this disease. When evaluated pharmacologically, most of the plants employed as antidiabetic substances have been shown to exhibit hypoglycemic and antihyperglycemic activities, and to contain chemical constituents that may be used as new antidiabetic agents. There are many substances extracted from plants that offer antidiabetic potential, whereas others may result in hypoglycemia as a side effect due to their toxicity, particularly their hepatotoxicity. In this article we present an updated overview of the studies on extracts from medicinal plants, relating the mechanisms of action by which these substances act and the natural principles of antidiabetic activity.

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Section: Cinnamomum Cassia and C Japonicamentioning

confidence: 66%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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“…(not specified) Ethanol Polyphenol (81.4%) 300-1200 mg/kg mice body weight Antidiabetic and anti-hyperglycemic effects: The cinnamon extract repaired pancreatic β cells [53] (Continued ) 200-300 mg/kg mice body weight Anti-hyperglycemic effect: TAPP and TBPP oligomer-rich extract from different cinnamon species had hypoglycemic effects both in vivo and in vitro experiment [180] *The phytochemical constituents were expressed as % (w/w). TAPP: Type-A-procyanidine polyphenols; DMSO: dimethyl sulfoxide; TBPP: type-B-procyanidine polyphenols.…”

Section: µG/mlmentioning

confidence: 99%

Cinnamon and its derivatives as potential ingredient in functional food—A review

Muhammad

Dewettinck

2017

International Journal of Food Properties

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Cinnamon has been reported to have significant benefits for human health, particularly as an anti-inflammatory, antitumor, anticancer, antidiabetic, and anti-hypertriglyceridemia agent, mainly due to its phytochemical constituents such as phenolic and volatile compounds. The phytochemicals in cinnamon can be extracted from different parts of plant by distillation and by solvent extraction. The use of cinnamon in food and its ability to prevent oxidation and inhibit microbial growth are covered in this review. Its bioaccessibility, safety, and consumer acceptance are comprehensively discussed. This review also clearly shows a route to the use of cinnamon as an ingredient in functional foods. ARTICLE HISTORY

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“…The cytotoxic effect of H. angustifolia root extract on HepG2, C2C12, and 3T3-L1 cells was determined by using MTT assay (Lu et al 2011). Briefly, HepG2, C2C12, and 3T3-L1 cells were seeded at a density of 5 Â 10 3 cells/well in 96-well plate and incubated for 24 h, and then incubated with various concentrations of H. angustifolia extract for another 24 h. After incubation, 10 mL MTT (5 mg/mL) was added into each well, incubated for 4 h, then the culture medium was removed before the addition of 100 mL DMSO.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Antidiabetic activity of Helicteres angustifolia root

Cheng

Zhang

2016

Pharmaceutical Biology

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ContextThe root of Helicteres angustifolia L. (Sterculiaceae) has been used as folk herbal drug to treat cancer, bacterial infections, inflammatory, and flu in China. However, there is no report on its antidiabetic activity. Objective This study evaluates the antidiabetic activity of ethanol extract from H. angustifolia root. Materials and methods The promoting effect of H. angustifolia root ethanol extract (25, 50, and 100 mg/mL) on glucose uptake was evaluated using HepG2 cell, differentiated C2C12 myotubes, and differentiated 3T3-L1 adipocytes. The antidiabetic activity of the extract was assessed in vivo using STZ-induced diabetic rats by orally administration of the extract (200 and 400 mg/kg b.w.) once per day for 28 d. Blood glucose, TG, TC, TP, HDL-C, UA, BUN, AST, ALT, insulin, and HOMA-IR were analyzed. Results The results showed that the extract increased glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes with an IC 50 value of 79.95 and 135.96 mg/mL, respectively. And about 12%, 19%, and 10% (p 5 0.05) in HepG2 cells when compared with the control at the concentration of 25, 50, and 100 mg/mL, respectively. After 28 days' treatment with the extract, significant reduction was observed in blood glucose, HOMA-IR, TC, TG, UA, BUN, AST, and ALT levels, while the levels of TP and HDL cholesterol increased. Discussion and conclusion These results suggest that H. angustifolia root ethanol extract possess potent antidiabetic activity, which is the first report on antidiabetic activity of this plant.

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Hypoglycemic activities of A- and B-type procyanidin oligomer-rich extracts from different Cinnamon barks

Cited by 86 publications

References 24 publications

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Cinnamon and its derivatives as potential ingredient in functional food—A review

Antidiabetic activity of Helicteres angustifolia root

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