Hypoglycemic Action ofCyclocarya paliurus(Batal.) Iljinskaja in Normal and Diabetic Mice

Abstract

This study examined the hypoglycaemic activity of Cyclocarya paliurus (Batal.) Iljinskaja (C. paliurus) in ICR mice by oral glucose tolerance testing. The blood glucose level was significantly lower in the C. paliurus extract treatment group than in the control group after animals were given sucrose. This difference was not observed following the administration of glucose. We demonstrated that the chronological change in the level of blood glucose in genetically hyperglycemic obese KK-Ay mice is significantly lower when C. paliurus extract is administered daily for three weeks. An in vitro study showed that C. paliurus inhibits alpha-glucosidase, a disaccharide-degrading enzyme in the small intestinal mucosa, leading to a decrease in the absorption of glucose into the blood and a subsequent lowering of the blood glucose level.

Terminalia belliricastimulates the secretion and action of insulin and inhibits starch digestion and protein glycationin vitro

“…Components of the extract responsible for this effect are unknown but it is noteworthy that several alkaloid compounds, including castonospermine from the seeds of Castanosperum australe, have established a-glucosidase-inhibitory action (3) . Moranoline (1-deoxynojirimycin), of which the therapeutic agent miglitol is a derivative, was originally isolated from mulberry root bark (Mori cortex) (21,22) . Several hydroxyflavonoid compounds have also been isolated from marjoram leaves, each exhibiting glucosidase-inhibitory activity (23) .…”

Variation in growth, photosynthesis and water-soluble polysaccharide of Cyclocarya paliurus under different light regimes

“…Leaves of this plant are traditionally used in China as a medicine or nutraceutical tea because of its unique taste (Birari & Bhutani 2007, Fang et al 2011. Many studies have demonstrated that C. paliurus has a variety of bioactivities, including hypoglycemic activity (Kurihara et al 2003), antihypertensive activity (Xie et al 2006), anti-HIV-1 (Zhang et al 2010), antioxidant activity (Xie et al 2010), and anticancer (Xie et al 2013). However, most studies on C. paliurus were focused on plant compounds (including triterpenoids, flavonoids, steroids and saponins) and the extract activities whereas less attention was paid to the silvics of the species (Deng et al 2012.…”

The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents

“…Administration of a C. paliurus extract (250 mg/kg) to mice suppressed the expected increase of blood glucose level following sucrose administration. 181 In addition, the oscillations in blood glucose levels found in genetically hyperglycemic obese KK-AY mice were significantly lower when C. paliurus (2 g/day) extract was administered daily for 3 weeks. To date, no research has been conducted on the hypoglycemic effect of this extract in clinical settings…”

“…Digestive enzyme inhibition in the management of obesity 73,203 Green tea catechins 5-30 μM inhibit adipocytes differentiation inhibit gastric and pancreatic lipase inhibit α-amylase and α-glucosidase [187][188][189]191,192 Cyclocarya paliurus 5 μg/mL 9.1 μg/mL inhibits α-glucosidase inhibits pancreatic lipase 180,181 Salacia reticulata polyphenol extracts salacinol and kotalanol iC 50 Once bound to these surfaces, colipase facilitates the interaction between pancreatic lipase and the surface of emulsified lipid droplets. 20 Although HPLRP1 and -2 share a high degree of structural homology and sequence with HPL, 21 their role in lipid digestion has not been fully clarified.…”