Hypoglycemia During the 100-g Oral Glucose Tolerance Test: Incidence and Perinatal Significance

Weissman, Amir; Solt, Ido; Zloczower, Moshe; Jakobi, Peter

doi:10.1097/01.aog.0000159577.28448.f9

Cited by 29 publications

(43 citation statements)

References 17 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This data was agreed with the data of previous studies. 17,18 The association between hypoglycemia with parity, mode of delivery, sex of the baby and glucose infusion received by the mother was studied, but no significant association was found. Diwakar et al in his study also concluded that no association was found between hypoglycemia and parity or mode of delivery.…”

Section: Discussionmentioning

confidence: 99%

The incidence of asymptomatic hypoglycemia in term newborn babies weighing more than two kilograms

Thirumalaikumarasamy

Ramalingam

Moorthi

et al. 2017

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Neonatal hypoglycemia is a common metabolic problem especially in cases like prematurity, sepsis and small gestational age. Episodes of asymptomatic hypoglycemia may occur due to many risk factors. The present study aimed to evaluate the incidence of asymptomatic hypoglycemia in term new born babies weighing more than 2 kg, to study the plasma sugar level at various time points during first 48 hours of life and to study the effect of maternal factors like parity, mode of delivery, glucose infusion during labour, and time since last feed on plasma sugar level.Methods: A hospital based longitudinal study was conducted over a period of one year from April 2005 to March 2006 in Kilpauk Medical College Hospital, Chennai. 400 babies born of consecutive deliveries were included in the study. Their plasma glucose levels were assessed in cord blood, 3 hr, 12 hr and 36 hr of life. Plasma glucose levels were analysed with regards to distribution, variables like parity, mode of delivery, dextrose infusion during labour and time since last feed. The plasma glucose levels were statistically analysed by paired student ‘t’ test, multiple analysis of variance (ANOVA), chi- square test using SPSS (version 7.5) statistical package.Results: The overall incidence of hypoglycemia was seen in 20% of the neonate’s in which 29.7% in small gestational age (SGA) and 16.7% in appropriate gestational age (AGA) babies. A significant (p <0.01) association between hypoglycemia and birth weight was observed. The association between hypoglycemia with parity, mode of delivery, sex of the baby and glucose infusion received by the mother was studied, but no significant association was found. A significant difference in plasma glucose based on birth weight at 3rd hour, 12th hour and 36th hour was observed (p <0.05). None of the infants showed any clinical signs of hypoglycemia.Conclusions: The incidence of hypoglycemia was noted in 20% of the neonates. Low birth weight was considered as risk factor. A significant association was also observed between plasma glucose, mode of delivery and time since last fed.

show abstract

Section: Discussionmentioning

confidence: 99%

The incidence of asymptomatic hypoglycemia in term newborn babies weighing more than two kilograms

Thirumalaikumarasamy

Ramalingam

Moorthi

et al. 2017

Int J Contemp Pediatr

View full text Add to dashboard Cite

show abstract

“…Although it is widely known that a significant number of women experience symptomatic hypoglycemia during OGTT, there are limited reports on the prevalence and perinatal significance of reactive hypoglycemia during the 100 g OGTT. Weissman et al , who defined hypoglycemia as ≤ 50 mg/dL, reported an incidence rate of 6.3% for reactive hypoglycemia during the test among 805 pregnant women over a 3-year period [3]. They found a lower incidence of gestational diabetes in women who experienced reactive hypoglycemia.…”

Section: Discussionmentioning

confidence: 99%

“…A few studies have evaluated the effects of reactive hypoglycemia on perinatal and neonatal outcomes, with conflicting results [3,4,[23][24][25]. Pugh et al compared 436 pregnant women who developed hypoglycemia during GCT with 434 normoglycemic pregnancies, and found that the hypoglycemic patients were significantly younger, had lower pre-pregnancy body mass indices, and were more likely to develop preeclampsia than normoglycemic women [4].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, Calfee et al found no relationships between hypoglycemia on GCT and fetal growth restriction or other adverse perinatal consequences [25]. Weissman et al even reported that reactive hypoglycemia was associated with favorable pregnancy outcomes, such as a lower rate of gestational diabetes, low birth weights, and cesarean delivery for macrosomia [3]. In the present study, we found that younger pregnant women were more likely to develop reactive hypoglycemia during the 3 h 100 g OGTT, which is significantly associated with adverse pregnancy outcomes, such as low APGAR scores, low birth weights, and prenatal admission to the NICU.…”

Section: Discussionmentioning

confidence: 99%

“…Some women who have abnormal test results (≥ 140 mg/dL) on the 50 g GCT experience hypoglycemia during the 3 h 100 g OGTT, with symptoms including dizziness, nausea, tachycardia, and perspiration, a condition known as reactive hypoglycemia [3,4]. Concomitant blood samples may reveal very low blood glucose levels in these women.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Does reactive hypoglycemia during the 100 g oral glucose tolerance test adversely affect perinatal outcomes?

Delibaş¹,

Tanrıverdi²,

Çakmak³

2018

Ginekol Pol

View full text Add to dashboard Cite

Objectives: To determine whether pregnant women who have reactive hypoglycemia during the 100 g oral glucose tolerance test (OGTT) are at an increased risk of poor pregnancy outcomes. Material and methods:We retrospectively analyzed perinatal data from 413 women who underwent a 3 h OGTT at 24-28 weeks of gestation and gave birth in our clinics between January 2012 and December 2014.Results: According to OGTT results, the majority of the subjects were normoglycemic (n = 316, 76.5%), while 49 (11.9%) were diagnosed with gestational diabetes, and 33 (8.0%) had single high glucose values. Reactive hypoglycemia was detected in only 15 patients (3.6%). The mean age of the women in the reactive hypoglycemia group was significantly lower than that of the women in the gestational diabetes and single high glucose value groups (26.4 ± 4.4 years, 31.4 ± 5.4 years, and 31.8 ± 4.3 years, respectively; p < 0.05). The newborns of the women in the reactive hypoglycemia group had higher rates of APGAR scores < 7, increased admission to the neonatal intensive care unit (NICU), and lower birth weights compared with the other groups (p < 0.001, p < 0.001, and p = 0.009, respectively). Conclusion:Reactive hypoglycemia during the 3 h 100 g OGTT is significantly associated with low APGAR scores, low birth weights, and prenatal admission to the NICU. Therefore, pregnant women who develop hypoglycemia during the 100 g OGTT performed at 24-28 weeks of gestation should receive attentive follow-up care to decrease the possibility of adverse perinatal outcomes.

show abstract

Hypoglycemia during the oral glucose tolerance test in pregnancy—maternal characteristics and neonatal outcomes

Raviv

Wilkof-Segev

Maor‐Sagie

et al. 2021

Intl J Gynecology & Obste

View full text Add to dashboard Cite

Gestational diabetes mellitus (GDM) is manifested by carbohydrate intolerance that develops during pregnancy and is associated with adverse maternal and neonatal outcomes. 1 In 2014, the US Preventive Services Task Force made a recommendation to screen all pregnant women for GDM at or beyond 24 weeks of gestation. 2 Screening is generally performed using the two steps approach: a 50-g glucose challenge test (GCT) at 24-28 weeks, followed by a diagnostic 100-g oral glucose tolerance test (OGTT) for those who screen positive. Women with increased risk for GDM (obesity, previous GDM, strong family history of diabetes, or previous macrosomia) are advised to directly undergo the diagnostic OGTT. GDM is classically diagnosed by two or more abnormal

show abstract

Hypoglycemia During the 100-g Oral Glucose Tolerance Test: Incidence and Perinatal Significance

Abstract: The incidence of reactive hypoglycemia during the 100-g oral glucose tolerance test in our population is 6.3%. Women who experience hypoglycemia during the test have a significantly lower incidence of gestational diabetes and neonatal birth weights.

Cited by 29 publications

References 17 publications

The incidence of asymptomatic hypoglycemia in term newborn babies weighing more than two kilograms

The incidence of asymptomatic hypoglycemia in term newborn babies weighing more than two kilograms

Does reactive hypoglycemia during the 100 g oral glucose tolerance test adversely affect perinatal outcomes?

Hypoglycemia during the oral glucose tolerance test in pregnancy—maternal characteristics and neonatal outcomes

Contact Info

Product

Resources

About