Hypoglycaemic Effects ofOpuntia ficus-indica Mill.,Opuntia lindheimeri Engelm andOpuntia robusta Wendl. in Streptozotocin-induced Diabetic Rats

Enigbokan, M. A.; Felder, Tyrone B.; Thompson, Jacob O.; Kuti, J.O.; Ekpenyong, Kieran I.

doi:10.1002/(sici)1099-1573(199608)10:5<379::aid-ptr849>3.0.co;2-i

Cited by 12 publications

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Cactus stems (Opuntia spp.): A review on their chemistry, technology, and uses

Stintzing

Carle

2005

Mol. Nutr. Food Res.

414

275

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Although traditionally used as a valuable health supporting nutrient, the vegetative parts of Opuntia spp. plants are scarcely used in modern nutrition and medicine. While all kinds of different Opuntia spp. have been studied, a systematic approach regarding the inter-relationships between the composition and the pre- and postharvest conditions is still missing. Therefore, the present review compiles and discusses literature on the chemical composition of cactus stems, the knowledge on uses in food, medicine, and cosmetics. It is concluded that much research is needed to get an insight into the multitude of bioactivities reported in the traditional literature but also to take advantage of the respective constituents for food and pharmaceutical applications.

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Cactus stems (Opuntia spp.): A review on their chemistry, technology, and uses

Stintzing

Carle

2005

Mol. Nutr. Food Res.

414

275

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Hypoglycaemic effect of Opuntia lindheimeri Englem. in a diabetic pig model

Laurenz

Collier

Kuti

2003

Phytotherapy Research

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The hypoglycaemic activity of Opuntia lindheimeri Englem. was investigated in non-diabetic (control pigs) and streptozotocin-induced diabetic pigs using an enteral (oral) route of administration. Following the administration of O. lindheimeri extract (0, 250 or 500 mg/kg body weight), blood glucose concentrations in control pigs fluctuated around initial baseline concentrations, but were not consistently affected by either the dose of O. lindheimeri or by the time following administration. In contrast, administration of O. lindheimeri extract to STZ-treated pigs resulted in both a dose- (p < 0.001) and time-dependent (p < 0.001) decrease in blood glucose concentrations. The hypoglycaemic effect of the extract was apparent within 1 h of administration, with maximal effects occurring at 4 h after administration. These results confirm the hypoglycaemic effect of O. lindheimeri extract in a diabetic pig model. In addition, given the physiological similarities of the pig to humans, this model will be of tremendous use in assessing the long-term effects of Opuntia administration on the secondary problems associated with diabetes.

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Comparative evaluation of two different Opuntia ficus‐indica extracts for blood sugar lowering effects in rats

Butterweck

Semlin

Feistel³

et al. 2011

Phytotherapy Research

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Stems of Opuntia ficus-indica (L.) Mill. (OFI) are traditionally used in Mexico to treat diabetes mellitus. Less research data are available for combinations of stem and fruit preparations. The present study was designed to investigate the effects of an aqueous extract prepared from the cladodes and a proprietary stem/fruit skin-blend (stem/fruit skin ratio 75/25) of OFI on blood glucose and plasma insulin in normal rats. A dose finding study with the traditional cladode OFI extract revealed that maximum effects on blood glucose and insulin were observed after oral administration in a dose range of 6-176 mg/kg. The proprietary OFI blend significantly lowered blood glucose levels in the glucose tolerance test to a similar extent (p < 0.05 vs control) as the traditional aqueous cladode extract when administered in a dose of 6 mg/kg. In contrast to the aqueous extract, the proprietary blend significantly increased basal plasma insulin levels (p < 0.01 vs control) indicating a direct action on pancreatic beta cells. The results suggest that both OFI extracts exert hypoglycemic activities in rats in doses as low as 6 mg/kg but that the effects of the proprietary stem/fruit blend were more pronounced in our model.

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Hypoglycaemic Effects ofOpuntia ficus-indica Mill.,Opuntia lindheimeri Engelm andOpuntia robusta Wendl. in Streptozotocin-induced Diabetic Rats

Cited by 12 publications

References 0 publications

Cactus stems (Opuntia spp.): A review on their chemistry, technology, and uses

Cactus stems (Opuntia spp.): A review on their chemistry, technology, and uses

Hypoglycaemic effect of Opuntia lindheimeri Englem. in a diabetic pig model

Comparative evaluation of two different Opuntia ficus‐indica extracts for blood sugar lowering effects in rats

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