Hypoglycaemic and Hypolipidemic Effects of Black Brand of Lipton Tea (Camellia sinensis) on Normal Male Albino Rats

Abstract

Recently, considerable attention has been focused on dietary supplements that possess hypoglycaemic and hypolipidemic properties in lieu of the synergistically synthesized drugs like statins and metiform which have been proven to have adverse effects. This present work was carried out to study the potential effects of Lipton tea aqueous extract (LTAE) on normal male albino rats. 36 six male Wistar rats weighing 115-150 g were assigned into four main groups; each group was divided into three subgroups, consisting of three replicates namely R1, R2 and R3 making a total of nine rats in each of the main groups. Group 1 served as the control and received only water, Group 2 received 200 mg/kg of LTAE, Group 3 received 400 mg/kg of the LTAE, while Group 4 received 800 mg/kg of LTAE. All treatment was given orally on daily basis for 28 consecutive days, but the parameters were assessed on weekly basis. The result revealed that, weight gain, fasting blood sugar and serum (total cholesterol, triglycerides, LDL-c and VLDL-c) significantly (p < 0.05) decrease in all the treated groups while HDL-c significantly (p < 0.05) increased when compared to the control group. The Lipton tea aqueous extract induced both a dose-dependent and a time-dependent effect in the parameters measured, apart from the total cholesterol which did not show a dose-dependent effect. This led to an overall decrease in the antherogenic index and coronary risk index, suggesting that LTAE possesses hypoglycaemic and hypoglycaemic activities in normal male rats.

Compound green tea (CGT) regulates lipid metabolism in high-fat diet induced mice

“…Studies on both human and animals have showed that tea consumption are associated with the blood lipid reduction and body weight loss. [9][10][11] Recently, considerable functional components were identied from tea, including polyphenols, 12 catechin, 13 EGCG and caffeine, 14 which are involved in promoting cholesterol reverse transport 15 through regulating key transcription factors of lipid metabolism 16 and activating lipid catabolism in liver. 17 Some reports have found that caffeine in tea was able to promote lipolysis in adipocytes, and it worked with catechins to inhibit triglyceride accumulation and adipocyte proliferation.…”