Hypoglycaemic and anti-ageing activities of green alga Ulva lactuca polysaccharide via gut microbiota in ageing-associated diabetic mice

Regulatory mechanisms of the green alga Ulva lactuca oligosaccharide via the metabolomics and gut microbiome in diabetic mice

“…Intriguingly, the abundances of Dubosiella, Oxalobacter, and Rikenella were significantly altered by supplementation with Met and ULOL. Our previous study also observed the abundance changes of Dubosiella and Rikenella in ULP intervention ( Chen et al, 2022 ), suggesting it may play a potential role in hypoglycaemia and anti-ageing. In addition, the abundances of both Family_XIII_AD3011_group and Family_XIII_UCG-001 seemed to be restored after the supplementation with ULOL, unlike the Model group.…”

“…Prior studies have suggested that GLP-1/GLP-1R activation can strengthen the secretion of glucose-dependent insulin and exerts a variety of external pancreas effects to promote antidiabetic effects ( Darsalia et al, 2014 ). In addition, the activation of GLP-1/GLP-1R contributes to control the feeding behavior and balance the diet-associated blood glucose fluctuations in T2D patients ( Chen et al, 2022 ). FoxO1 is a multitarget conservative transcription factor that is involved in apoptosis and autophagy, antioxidant, energy metabolism, and immune regulation ( Xing et al, 2018 ).…”

Global seaweed farming and processing in the past 20 years

“…Green seaweed polysaccharide is a kind of acidic polysaccharide (such as sulfated polysaccharides, sulfated galactans and xylans) located on the cell wall of green seaweed. It has special molecular structure and can play a variety of biological functions by regulating cell signal transduction function, such as anti-hyperuricemia, anti-oxidation, anti-coagulation, anti-virus, and blood glucose regulation (Cao et al 2022;Chen et al 2022;Li et al , 2021aLi et al , 2021bLin et al 2020;Wang et al 2020aWang et al , 2020bWang et al , 2013aWang et al , 2013bWassie et al 2021;Wu et al 2020). Chlorella is a type of single-celled green seaweed.…”

Genistein improves glucose metabolism and promotes adipose tissue browning through modulating gut microbiota in mice

“…65,66 In addition, both Ruminiclostridium and Clostridium_sensu_stricto_1 were also confirmed to be butyrate producers [67][68][69] and their reduced abundance has been linked to hypertriglyceridemia of human cohorts 70,71 and rodent models. 72 In contrast, an improvement of glucose metabolism by almonds, 73 uridine, 74 casein glycomacropeptide hydrolysate, 75 phosphatidylcholines, 76 green alga Ulva lactuca polysaccharide, 77 geraniin, 78 tea water extracts, 79 traditional Chinese medicines Scutellariae radix and coptidis rhizoma 57 were all positively correlated with the abundance of these bacterial genera. Although the exact function of Rikenella is still unclear, Cai et al 80 found that Rikenella was involved in the action of resveratrol in ameliorating the progression of DM.…”