Hypoglycaemic activity ofPterocarpus marsupium Roxb.

Abstract

The antidiabetic activity of various subfractions of the alcohol extract of the bark of Pterocarpus marsupium Roxb. was evaluated in alloxan-induced diabetic rats. The effect of these extracts on lipid profile and liver function tests were also assessed to evaluate their activity in controlling diabetes related metabolic alterations. The parameters measured were plasma glucose, total protein, cholesterol, triglycerides, alkaline phosphatase, SGOT and SGPT. The results indicate the effective role of Pterocarpus marsupium on the above mentioned parameters indicating that Pterocarpus marsupium can also control the diabetes related metabolic alterations apart from controlling the glucose levels. Among the fractions tested the butanol subfraction was found to be more active in comparison with other subfractions. It can be concluded that the butanol subfraction of the alcohol extract of Pterocarpus marsupium exhibits significant antidiabetic activity and corrects the metabolic alterations in diabetic rats and this activity may resemble insulin-like properties.

Modulation of Pimpinella tirupatiensis aqueous extract on Brain Mitochondrial Enzymes in STZ induced diabetic rats

“…However with Pimpinella tirupatiensis treatment to STZ diabetic rats reduced blood glucose levels, in accordance with earlier reports (Dhanabal et al, 2006). In the current study, the blood glucose data clearly showed that Pimpinella tirupatiensis restrained the level of hyperglycemia resulting from the experimental destruction of beta pancreatic cells induced by STZ.…”

Hypoglycaemic effects of Mammea africana (Guttiferae) in diabetic rats

“…Total protein (g/l) Creatinine (mg/l) Total cholesterol (mg/dl) Triglycerides (mg/dl) ALAT (u/l) ASAT (u/l) triglycerides and total cholesterol (Dhanabal et al, 2006;Saravanan and Pari, 2006). In our study, we have observed that non-treated diabetic rats, not only presented hyperglycaemia which persisted as far as on 21st day after STZ injection, but also elevated serum triglycerides and total cholesterol levels.…”

Increased Glucose Uptake and Insulin Binding Activity of Nerium Oleander in Hepatocytes and Adipocytes

“…The World Health Organization Expert Committee on diabetes has recommended that traditional medicinal herbs be further investigated 1,4 . Some of the most common plants used traditionally for treatment of diabetes are Pterocarpus marsupium 5 , Bitter Melon Nerium oleander (N.O.) is a member of Apocynaceae familia and grown in Mediterrian region.…”