Hypoglycaemic activity and molecular mechanisms of Caesalpinia ferrea Martius bark extract on streptozotocin-induced diabetes in Wistar rats

Vasconcelos, Carlos Fernando Brasileiro de; Maranhão, H.M.L.; Batista, Thiago M.; Carneiro, E. M.; Ferreira, Fabiano; Costa, Jean; Soares, Luiz Alberto Lira; Sa, McCreary; Souza, Tatiane Pereira de; Wanderley, Almir Gonçalves

doi:10.1016/j.jep.2011.08.059

Cited by 84 publications

(70 citation statements)

References 28 publications

(24 reference statements)

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“…AMPK activation also leads to ACC inhibition, allowing the oxidation of fatty acids [39]. This explains the low levels of total cholesterol, triglycerides, and epididymis adipose tissue [40].…”

Section: Caesalpinia Ferreamentioning

confidence: 99%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

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■ AbstractDiabetes mellitus is a chronic disease and a leading cause of death in western countries. Despite advancements in the clinical management of the disease, it is not possible to control the late complications of diabetes. The main characteristic feature of diabetes is hyperglycemia, which reflects the deterioration in the use of glucose due to a faulty or poor response to insulin secretion. Alloxan and streptozotocin (STZ) are the chemical tools that are most commonly used to study the disease in rodents. Many plant species have been used in ethnopharmacology or to treat experimentally symptoms of this disease. When evaluated pharmacologically, most of the plants employed as antidiabetic substances have been shown to exhibit hypoglycemic and antihyperglycemic activities, and to contain chemical constituents that may be used as new antidiabetic agents. There are many substances extracted from plants that offer antidiabetic potential, whereas others may result in hypoglycemia as a side effect due to their toxicity, particularly their hepatotoxicity. In this article we present an updated overview of the studies on extracts from medicinal plants, relating the mechanisms of action by which these substances act and the natural principles of antidiabetic activity.

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Section: Caesalpinia Ferreamentioning

confidence: 99%

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Gushiken¹,

Beserra²,

Rozza³

et al. 2016

Rev Diabet Stud

View full text Add to dashboard Cite

show abstract

“…Unexpectedly, these agents produce serious side effects in the clinical application, such as weight gain, gastrointestinal disturbances, edema, hypoglycemia and insulin resistance [12]. Therefore, it is important to discover alternative therapies that may have less or no side effects [13].…”

Section: Introductionmentioning

confidence: 99%

Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit

Navghare

Dhawale

2016

Ind J Clin Biochem

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Musa cavendish, peels has local and traditional use to promote wound healing, hyperglycemia, ulceration etc. The present work investigated the lipid lowering; nephroprotective and glucose lowering properties of ethanolic extract of peels of Musa cavendish (EMC) in alloxan-induced diabetic rats. The EMC 250, 500 and 1000 mg/kg/day and the vehicle were administered orally to alloxan-induced diabetic rats (n = 6) for 3 weeks. Changes in plasma glucose, lipid profile along with kidney function before and after treatment with EMC were recorded. The ethanolic extract of peels of Musa cavendish reduced blood glucose, serum triglyceride, cholesterol, LDL cholesterol and creatinine levels and improvement in body weight, liver glycogen, serum HDL cholesterol, serum albumin and total protein level when compared with untreated rats. Musa cavendish has lipid lowering, nephroprotective and antidiabetic property by regulating glucose uptake in the liver and muscles by restoring the intracellular energy balance.

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“…belongs to the legume family and is an economically important species with multiple applications in construction, which utilizes its wood, and in folk medicine, where fractions of stem and fruit extracts are used to treat bronchopulmonary and gastrointestinal disorders and diabetes (Lucinda et al, 2010;Vasconcelos et al, 2011). Nakamura et al (2002) and Pereira et al (2012) reported the antitumor and anti-inflammatory properties of its fruit, which is an excellent source of energy with a large carbohydrate content that is used to feed ruminants.…”

Section: Introductionmentioning

confidence: 99%

Short Communication Comparison of methods to isolate DNA from Caesalpinia ferrea

et al. 2014

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ABSTRACT. Molecular markers are important for characterizing the genetic diversity of plants and can provide the basis for strategies to protect and conserve endangered populations. However, numerous molecular techniques are used, requiring an evaluation of fast and efficient methods to extract DNA. Since molecular studies of Caesalpinia ferrea are rare, it is important to develop and/or adapt a DNA extraction protocol that produces quality DNA samples to enable the design of strategies for the conservation of this threatened species. This study aimed to compare five methods for DNA extraction and to determine the most efficient protocol for C. ferrea. Sufficient genomic DNA was obtained from the leaves of C. ferrea using all the tested protocols to perform techniques DNA extraction from Caesalpinia ferrea involving molecular markers. Two protocols based on the detergent cetyl trimethyl ammonium bromide, as well as a commercial kit, yielded high concentrations of pure DNA. However, when polymerase chain reaction amplifications were performed, DNA was only successfully amplified from extractions performed with the commercial kit, which produced sufficient genomic DNA of good quality from the leaves of C. ferrea to perform techniques involving molecular markers.

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Hypoglycaemic activity and molecular mechanisms of Caesalpinia ferrea Martius bark extract on streptozotocin-induced diabetes in Wistar rats

Cited by 84 publications

References 28 publications

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Chemical and Biological Aspects of Extracts from Medicinal Plants with Antidiabetic Effects

Suppression of Type-II Diabetes with Dyslipidemia and Nephropathy by Peels of Musa cavendish Fruit

Short Communication Comparison of methods to isolate DNA from Caesalpinia ferrea

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