Hypogeusia, Dysgeusia, Hyposmia, and Dysosmia following Influenza-Like Infection

Abstract

Hypogeusia, with or without dysgenusia, and hyposmia, with or without dysosmia, followed an influenzal-like infection in 87 of 143 consecutive patients who presented at the Taste and Smell Clinic at the NIH with taste and smell abnormalities. Findings in this disease included pale nasal mucous membranes with marked patency of the nasal airway, a postive Rudolph sign, elevated detection and recognition thresholds for several tastants and odorants, disruption of the pore region of the tast dub observed on electron microscopy and infiltration of the upper lamina propria of the nasal mucous membrane wih chronic inflammatory cells observed on light microscopy. These findings, taken together, are relatively specific for the diagnosis of this surprisingly common disorder.

Taste evaluation in adolescents and pediatric patients with benign migratory glossitis

“…Patients with infectious diseases such as upper respiratory viral infection, oral cavity infection, or viral hepatitis, frequently develop taste abnormalities characterized by increased detection and recognition thresholds for various taste stimuli [23][24][25][26][27][28]. Thus, this study was designed to investigate whether the presence of lesions associated with BMG could produce some damage to the perception of taste because it alters the epithelial surface of the tongue.…”

Sonic Hedgehog in Nasal Mucus is a Biomarker for Smell Loss in Patients with Hyposmia

“…Patients exhibited six etiologies related to their smell loss: post-influenza-like hyposmia (PIHH) [27] (10 patients), allergic rhinitis [28] (15 patients), congenital hyposmia [29] (nine patients), head injury [30] (eight patients), post general anesthesia [31] (one patient) and dysgeusia and oropyrosis [26] (one patient). Patients were not taking any medications at the time this study was performed.…”

Aetiological relationships of nasal mucus cyclic nucleotides in patients with taste and smell dysfunction

“…The majority of patients (91 patients) had the most common cause of taste and smell dysfunction, that following a viral-type illness labelled post-influenza-like hyposmia and hypogeusia (PIHH) 8. The next greatest incidence (50 patients) was related to allergic rhinitis 9.…”