Hypocholesterolemic effects of Lactobacillus plantarum KCTC3928 by increased bile acid excretion in C57BL/6 mice

Jeun, Jungae; Kim, Sukyung; Cho, Sung Yun; Jun, Hee-Jin; Park, Hyun Jin; Seo, Jae Gu; Chung, Myung Jun; Lee, Sung Joon

doi:10.1016/j.nut.2009.04.011

Cited by 130 publications

(73 citation statements)

References 42 publications

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“…In support of this, it has been shown that oral feeding of Lactobacillus plantarum KCTC3928 to mice resulted in significantly decreased LDL-C and TG, increased fecal bile-acid excretion, increased hepatic bile-acid synthesis, and increased expression of 7-alpha-hydroxylase (CYP7A1), the key enzyme in catabolism of cholesterol and bile-acid synthesis. 39 Such changes in lipid homeostasis and gene expression are consistent with what is known regarding the action of bile acids on farnesoid X receptor and LXR, including the findings that farnesoid X receptor activation by bile acids causes induction of small heterodimer partner and feedback inhibition of bile-acid synthesis by reducing expression of 7-alpha-hydroxylase (CYP7A1). 40,41 In turn, reduced small heterodimer partner inhibition of LXR results in reduced triglyceride and cholesterol biosynthesis 42 and stimulation of cholesterol export from cells through expression of ABCG5/G8 transporters.…”

Section: Weeksupporting

confidence: 75%

Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial

2012

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BACKGROUND/OBJECTIVES:The percentage of hypercholesterolemic individuals not reaching their LDL-cholesterol (LDL-C) goal remains high and additional therapeutic strategies should be evaluated. The objective of this study was to evaluate the cholesterollowering efficacy and mechanism of action of bile salt hydrolase-active Lactobacillus reuteri NCIMB 30242 capsules in hypercholesterolemic adults. SUBJECTS/METHODS: A total of 127 subjects completed a randomized, double-blind, placebo-controlled, parallel-arm, multicenter study. Subjects were randomized to consume L. reuteri NCIMB 30242 capsules or placebo capsules over a 9-week intervention period. The primary outcome was LDL-C relative to placebo at the study end point. RESULTS: L. reuteri NCIMB 30242 capsules reduced LDL-C by 11.64% (Po0.001), total cholesterol by 9.14%, (Po0.001), non-HDLcholesterol (non-HDL-C) by 11.30% (Po0.001) and apoB-100 by 8.41% (P ¼ 0.002) relative to placebo. The ratios of LDL-C/HDLcholesterol (HDL-C) and apoB-100/apoA-1 were reduced by 13.39% (P ¼ 0.006) and 9.00% (P ¼ 0.026), respectively, relative to placebo. Triglycerides and HDL-C were unchanged. High-sensitivity C-reactive protein and fibrinogen were reduced by 1.05 mg/l (P ¼ 0.005) and 14.25% (P ¼ 0.004) relative to placebo, respectively. Mean plasma deconjugated bile acids were increased by 1.00 mmol/l (P ¼ 0.025) relative to placebo, whereas plasma campesterol, sitosterol and stigmasterol were decreased by 41.5%, 34.2% and 40.7%, respectively. CONCLUSIONS: The present results suggest that the deconjugation of intraluminal bile acids results in reduced absorption of non-cholesterol sterols and indicate that L. reuteri NCIMB 30242 capsules may be useful as an adjunctive therapy for treating hypercholesterolemia.

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Section: Weeksupporting

confidence: 75%

Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial

2012

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“…[21] In in vivo experiments, double-coated live L. plantarum KCTC3928 has demonstrated hypocholesterolaemic effects in mice. [22] In the present study, we showed that dual-coated and uncoated probiotic supplements have hepatoprotective effects. Although the hepatoprotective mechanisms of probiotics were not addressed in this study, potential mechanisms were identified.…”

Section: Parameterssupporting

confidence: 50%

Hepatoprotective effects of dual-coated and uncoated mixture of probiotics in rats

Park

Lee

Kim

et al. 2015

Biotechnology & Biotechnological Equipment

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Probiotics have been used for the treatment of various disorders or as alternative therapies. The stability of dual-coated probiotics is increased in the gastrointestinal environment. The aim of the present study was to evaluate the hepatoprotective effects of dual-coated and uncoated probiotic supplements, following liver injury. Albino Wistar rats were orally treated with probiotics daily and carbon tetrachloride (CCl 4 ) was administered on the seventh and eighth days to induce acute liver damage. Hepatoprotective effects were determined by assessment of serum glutamicÀoxaloacetic transaminase (SGOT) and serum glutamicÀpyruvic transaminase (SGPT) activities, as well as by histopathological examination. The CCl 4 -treated control group showed increased SGOT and SGPT activities as compared with the normal control group. However, treatment with probiotics reduced SGOT and SGPT activities, following CCl 4 administration. Animals treated with probiotics showed reduced liver weight than that in the standard CCl 4 group which did not receive probiotics. Histopathological analysis showed that administration of probiotics minimized liver damage by reducing the level of morphological changes and necrosis. Therefore, probiotics may be effective hepatoprotective agents and should be considered useful for the treatment and prevention of hepatic disorders.

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“…The L. plantarum PH04 strain was isolated from infant faeces and reported to be able to produce bile salt hydrolase enzyme in vitro. In another study, Jeun et al [5] demonstrated that LDL-C was significantly (P < 0.05) lower (by 42%) in mice fed L. plantarum KCTC3928 and fecal bile acid excretion was accelerated (45%). They also found expressions of the LDL-receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase were marginally affected by feeding L. plantarum KCTC3928 but interestingly the gene expression and protein levels of CYP7A1 were significantly upregulated [5].…”

Section: Hypocholesterolaemic Effects Of Probioticsmentioning

confidence: 96%

“…In another study, Jeun et al [5] demonstrated that LDL-C was significantly (P < 0.05) lower (by 42%) in mice fed L. plantarum KCTC3928 and fecal bile acid excretion was accelerated (45%). They also found expressions of the LDL-receptor and 3-hydroxy-3-methylglutaryl coenzyme A reductase were marginally affected by feeding L. plantarum KCTC3928 but interestingly the gene expression and protein levels of CYP7A1 were significantly upregulated [5]. The gene CYP7A1 encodes for cholesterol 7-α-hydroxylase, the rate-limiting enzyme in the bile acid biosynthetic pathway in liver and thus controls cholesterol and bile acid homeostasis [65].…”

Section: Hypocholesterolaemic Effects Of Probioticsmentioning

confidence: 96%

“…Probiotics are beneficial bacteria that influence the health of the host by improving their microbial balance. Modifications of intestinal flora have been shown to be beneficial on lipid metabolism in mice [2][3][4][5][6], rats [7][8][9][10][11], guinea pigs [12] and pigs [13]. In contrast, studies in humans [14,15] indicated that the role of fermented milk products as hypocholesterolaemic agents were inconsistent but more reliable effects were documented in the recent clinical studies [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hypocholesterolaemic Effects of Probiotics

Ramasamy¹,

Shafawi²,

Mani³

et al. 2012

Complementary Therapies for the Contemporary Healthcare

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Hypocholesterolemic effects of Lactobacillus plantarum KCTC3928 by increased bile acid excretion in C57BL/6 mice

Cited by 130 publications

References 42 publications

Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial

Cholesterol lowering and inhibition of sterol absorption by Lactobacillus reuteri NCIMB 30242: a randomized controlled trial

Hepatoprotective effects of dual-coated and uncoated mixture of probiotics in rats

Hypocholesterolaemic Effects of Probiotics

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