Hypocalcemic Rickets and Dilated Cardiomyopathy: Case Reports and Review of Literature

Brown, Jennifer M.; Nunez, Susan B.; Russell, M D; Spurney, Christopher F.

doi:10.1007/s00246-009-9444-z

Cited by 71 publications

(67 citation statements)

References 13 publications

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“…Several case reports highlight pediatric cardiomyopathies, which are associated with vitamin D deficiency or rickets [73][74][75][76][77][78][79][80][81]. Importantly, children with vitamin D deficiency associated heart failure showed in most cases a significant clinical improvement after vitamin D and calcium supplementation [73][74][75][76][77][78][79][80].…”

Section: Vitamin D and Myocardial Dysfunction In Humans 71 Vitamin Dmentioning

confidence: 99%

“…Importantly, children with vitamin D deficiency associated heart failure showed in most cases a significant clinical improvement after vitamin D and calcium supplementation [73][74][75][76][77][78][79][80]. A post mortem examination of a child who died due to vitamin D deficiency associated cardiomyopathy showed a large pericardial effusion and an enlarged heart with a dilated and concentric hypertrophic left ventricle [73].…”

Section: Vitamin D and Myocardial Dysfunction In Humans 71 Vitamin Dmentioning

confidence: 99%

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Vitamin D deficiency and myocardial diseases

Pilz

Tomaschitz

Drechsler

et al. 2010

Molecular Nutrition Food Res

134

142

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Vitamin D deficiency is common among patients with myocardial diseases because sun-induced vitamin D production in the skin and dietary intake of vitamin D is often insufficient. Knockout mice for the vitamin D receptor develop myocardial hypertrophy and dysfunction. It has also been shown that children with rickets who suffered from severe heart failure could be successfully treated with supplementation of vitamin D plus calcium. In adults, almost all patients with heart failure exhibit reduced 25-hydroxyvitamin D levels, which are used to classify the vitamin D status. In prospective studies, vitamin D deficiency was an independent risk factor for mortality, deaths due to heart failure and sudden cardiac death. Several vitamin D effects on the electrophysiology, contractility, and structure of the heart suggest that vitamin D deficiency might be a causal factor for myocardial diseases. Data from interventional trials, however, are rare and urgently needed to elucidate whether vitamin D supplementation is useful for the treatment of myocardial diseases. In our opinion, the current knowledge of the beneficial effects of vitamin D on myocardial and overall health strongly argue for vitamin D supplementation in all vitamin D-deficient patients with or at high risk for myocardial diseases.

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Section: Vitamin D and Myocardial Dysfunction In Humans 71 Vitamin Dmentioning

confidence: 99%

Section: Vitamin D and Myocardial Dysfunction In Humans 71 Vitamin Dmentioning

confidence: 99%

Vitamin D deficiency and myocardial diseases

Pilz

Tomaschitz

Drechsler

et al. 2010

Molecular Nutrition Food Res

134

142

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“…There is abundant, yet low-quality evidence from multiple case reports, case series [11,48,49,88] , and observational studies [1,2,45,50,85,[89][90][91][92][93][94][95][96][97][98][99] that exclusive breast-feeding without vitamin D supplementation is a major risk factor for NR in infants. Furthermore, prolonged breast-feeding with late introduction of complementary feeding is associated with NR in infants not receiving vitamin D supplements [26,[100][101][102][103][104][105] .…”

Section: Evidencementioning

confidence: 99%

Global Consensus Recommendations on Prevention and Management of Nutritional Rickets

Munns¹,

Shaw²,

Kiely³

et al. 2016

Horm Res Paediatr

355

477

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Background: Vitamin D and calcium deficiencies are common worldwide, causing nutritional rickets and osteomalacia, which have a major impact on health, growth, and development of infants, children, and adolescents; the consequences can be lethal or can last into adulthood. The goals of this evidence-based consensus document are to provide health care professionals with guidance for prevention, diagnosis, and management of nutritional rickets and to provide policy makers with a framework to work toward its eradication. Evidence: A systematic literature search examining the definition, diagnosis, treatment, and prevention of nutritional rickets in children was conducted. Evidence-based recommendations were developed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) system that describes the strength of the recommendation and the quality of supporting evidence. Process: Thirty-three nominated experts in pediatric endocrinology, pediatrics, nutrition, epidemiology, public health, and health economics evaluated the evidence on specific questions within five working groups. The consensus group, representing 11 international scientific organizations, participated in a multiday conference in May 2014 to reach a global evidence-based consensus. Results: This consensus document defines nutritional rickets and its diagnostic criteria and describes the clinical management of rickets and osteomalacia. Risk factors, particularly in mothers and infants, are ranked, and specific prevention recommendations including food fortification and supplementation are offered for both the clinical and public health contexts. Conclusion: Rickets, osteomalacia, and vitamin D and calcium deficiencies are preventable global public health problems in infants, children, and adolescents. Implementation of international rickets prevention programs, including supplementation and food fortification, is urgently required. nology, pediatrics, nutrition, epidemiology, public health, and health economics evaluated the evidence on specific questions within five working groups. The consensus group, representing 11 international scientific organizations, participated in a multiday conference in May 2014 to reach a global evidence-based consensus. Results: This consensus document defines nutritional rickets and its diagnostic criteria and describes the clinical management of rickets and osteomalacia. Risk factors, particularly in mothers and infants, are ranked, and specific prevention recommendations including food fortification and supplementation are offered for both the clinical and public health contexts. Conclusion: Rickets, osteomalacia, and vitamin D and calcium deficiencies are preventable global public health problems in infants, children, and adolescents. Implementation of international rickets prevention programs, including supplementation and food fortification, is urgently required. Key WordsRickets · Nutrition · Vitamin D · Calcium · Consensus recommendations Abstract Background: Vitamin D and ca...

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“…As etiologias da hipocalcemia foram diversas, incluindo os hipoparatiroidismos iatrogénico 4,24 e autoimune 13,25 e o raquitismo 18,20,28 . Em alguns dos casos descritos a insuficiência coronária não terá sido formalmente excluída por coronariografia 4,22,25 .…”

Section: Discussionunclassified

Miocardiopatia hipocalcémica

Aguiar

Cruz

Rodrigues

et al. 2013

Revista Portuguesa de Cardiologia

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The association between hypocalcemia and heart failure is rare. There are few reported cases in the literature of this association, which is termed hypocalcemic cardiomyopathy. We report the case of a 61-year-old woman with no relevant medical history, admitted for progressively worsening exertional dyspnea, orthopnea and edema of the lower limbs for a previous month. Physical examination showed diffuse muscle spasms, with no signs of latent tetany.Further investigation revealed ionized calcium 0.54 mmol/l (normal 1.12-1.30), phosphorus 9.8 mg/dl, parathyroid hormone <2.5 pg/ml and CK >3000 U/l, with normal thyroid function. The electrocardiogram showed long QT interval and a pattern of left ventricular overload, and myocardial biomarkers were negative. The echocardiogram revealed regional wall motion abnormalities, coronary angiography was normal and a cranial CT scan detected calcification of basal ganglia and white matter. She started diuretic and calcium replacement therapy which resulted in complete clinical recovery, with no need for heart failure therapy after normalization of serum calcium.

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Hypocalcemic Rickets and Dilated Cardiomyopathy: Case Reports and Review of Literature

Cited by 71 publications

References 13 publications

Vitamin D deficiency and myocardial diseases

Vitamin D deficiency and myocardial diseases

Global Consensus Recommendations on Prevention and Management of Nutritional Rickets

Miocardiopatia hipocalcémica

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