Hypocalcaemia in a patient with congenital heart disease

McCusker, L A; Jenkins, Nicholas; Hancock, J E

doi:10.1177/014107680710000117

Cited by 3 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Patients can remain symptom-free if hypocalcemia develops slowly ( 52 ). In our review ( Table ), 5 cases had asymptomatic hypocalcemia at the time of their 22q11.2 DS diagnosis ( 14 , 35 , 43 , 44 , 46 ). Second, some patients have an inadequate parathyroid function manifesting as a reduced PTH reserve ( 53 ).…”

Section: Discussionmentioning

confidence: 87%

An Adult Case of Chromosome 22q11.2 Deletion Syndrome Associated with a High-positioned Right Aortic Arch

Hoshino¹,

Machida²,

Shimano³

et al. 2017

Intern. Med.

View full text Add to dashboard Cite

Chromosome 22q11.2 deletion syndrome (22q11.2 DS) has a very wide phenotypic spectrum that includes dysmorphic features, cardiac anomalies, and hypocalcemia arising from hypoparathyroidism. We herein describe an adult case of 22q11.2 DS with associated hypoparathyroidism and anomalies of the aortic arch. Because the patient had been diagnosed with primary hypoparathyroidism at another hospital, a diagnosis of 22q11.2 DS had been overlooked. A chest X-ray examination revealed widening of the mediastinum caused by a high-positioned right aortic arch, and we subsequently confirmed a diagnosis of 22q11.2 DS using fluorescence in situ hybridization. Because primary hypoparathyroidism is a rare disorder, physicians should be aware of the variable phenotypic features of 22q11.2 DS.

show abstract

Section: Discussionmentioning

confidence: 87%

An Adult Case of Chromosome 22q11.2 Deletion Syndrome Associated with a High-positioned Right Aortic Arch

Hoshino¹,

Machida²,

Shimano³

et al. 2017

Intern. Med.

View full text Add to dashboard Cite

show abstract

“…Inadequate levels of Ca 2+ can impair the ability of the heart muscle to contract properly, potentially leading to decreased cardiac function [86]. According to the published articles, it was suggested that hypocalcemia may have contributed to the deterioration of cardiac function by impairing myocardial contractility and increasing the risk of arrhythmias and mortality [87][88][89][90] (Table 2). Consequently, low levels of Ca 2+ in the blood may indicate the presence of endocarditis.…”

Section: Hypocalcemia and Infectious Endocarditismentioning

confidence: 99%

“…2007 [90] Infective endocarditis with hypocalcaemia and facial dymorphism in an adolescent girl Rózsai et al…”

mentioning

confidence: 99%

Exploring the Risk Factors and Possible Role of Calcium in Infective Endocarditis

Kuo

Tsai

2023

Diagnostics

View full text Add to dashboard Cite

Infective endocarditis (IE) is a severe and potentially life-threatening infection that affects the endocardium, the inner lining of the heart chambers and valves. Although rare, it is a potentially fatal condition, with an incidence of 3–10 cases per 100,000 people per year in developed countries and a mortality rate of up to 30% within 30 days. Early identification and diagnosis are critical for improving outcomes. The diagnosis of IE typically involves a combination of biomarkers, blood cultures, and echocardiography. However, currently, there are no specific biomarkers for the early detection of IE. Given the lack of specific biomarkers for IE, serum calcium levels have been suggested to play a unique role in IE. There have been few articles on the correlation between serum calcium and IE, suggesting that patients with endocarditis and lower levels of serum calcium may have a poorer prognosis. Therefore, in this article, we focus on biomarkers of endocarditis and discuss the evidence showing serum calcium as a potential indicator of IE.

show abstract

Hypoparathyroidism and late-onset hypogonadism in an adult male with familial 22q11.2 deletion syndrome: a case report with 3-year follow-up and review of the literature

Chen

Yang

et al. 2022

BMC Endocr Disord

View full text Add to dashboard Cite

Background 22q11.2 deletion syndrome (DiGeorge syndrome) is associated with multiple organ dysfunctions such as cardiac defects, immunodeficiency, and hypoplasia of parathyroid glands. Moreover, the phenotype of 22q11.2 DS has clinical variability and heterogeneity. Case presentation In this report, we present the case of a 35-year-old patient with a past medical history that included recurrent infections, mild learning difficulties in childhood, pediatric obesity, and cataract. He was admitted to the endocrinology department for the management of hypogonadism and hypocalcemia. During the 3-year follow-up, the patient gradually developed primary hypoparathyroidism, hypogonadism, chronic renal failure, and heart failure, and his medical condition deteriorated. Meanwhile, in order to improve clinicians’ awareness of the endocrine manifestations of adult 22q11.2 DS and reduce missed diagnoses, we reviewed 28 case reports of adult 22q11.2 DS to analyze the clinical characteristics. Discussion Here, we report the case of a young man diagnosed with 22q11.2 DS presented a rare combination of multiple endocrine disorders. This is the first time that a patient with 22q11.2DS had late-onset hypogonadism caused by primary testicular failure combined with decreased pituitary gonadotropin reserve in a patient with 22q11.2DS.

show abstract

Hypocalcaemia in a patient with congenital heart disease

Cited by 3 publications

References 4 publications

An Adult Case of Chromosome 22q11.2 Deletion Syndrome Associated with a High-positioned Right Aortic Arch

An Adult Case of Chromosome 22q11.2 Deletion Syndrome Associated with a High-positioned Right Aortic Arch

Exploring the Risk Factors and Possible Role of Calcium in Infective Endocarditis

Hypoparathyroidism and late-onset hypogonadism in an adult male with familial 22q11.2 deletion syndrome: a case report with 3-year follow-up and review of the literature

Contact Info

Product

Resources

About