A B S T R A C T The article draws on two separate studies employing developmental vignettes (hypothetical scenarios which unfold through a series of stages) to interview research participants. One study used the 'Davie' vignette, which was a conventional fixed narrative, while in the second, the 'Jack and Jenny' vignettes were made interactive by hyperlinking a series of PowerPoint scenarios and making the choice of the succeeding slide dependent on the interviewee's reaction to its predecessor. Our analytic standpoint, in respect of both vignettes, is that of Schutzian phenomenology. We point to differences in both topical and motivational relevances in the processes of interpretation undergone by participants in considering the vignette scenario and in the situation of action. However, we show that research participants' responses to vignettes can yield data of interest in their own right as participants perform 'Thou-orientations' and 'They-orientations' in their consideration of the stimuli. We close with a comparative evaluation of the fixed 'Davie' and the interactive 'Jack and Jenny' vignettes. K E Y W O R D S : ethnomethodology, longitudinal interviewing, phenomenology, substance misuse, vignettes What are vignettes? As a sociological research tool, vignettes have been defined as:A technique used in structured and depth interviews as well as focus groups, providing sketches of fictional (or fictionalized) scenarios. The respondent is then invited to imagine, drawing on his or her own experience, how the central character A R T I C L E

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Further investigations are necessary to explore the interface between personal-emotional and career-related factors. The authors examined links between participants' emotional life, including depression and positive/negative affect, and career decision status and average level of vocationally relevant self-efficacy in a sample of 388 university students. Participants who had made a career decision were significantly less depressed, as measured by the Center for Epidemiologic Studies Depression Scale, than those who were undecided about their career. Furthermore, the authors found no significant difference in the average level of positive affect or negative affect, as measured by the Positive and Negative Affect Schedule, across career choice status groups. Gender accounted for 8.4% of the variation in overall average level of self efficacy, as measured by the Kuder Skills Assessment—College and Adult Version, and positive affect significantly contributed incremental variance (12.7%). The importance of addressing depression and affectivity in vocational research and practice is discussed.

Taken together, our data demonstrates that downregulation of microRNA-24 promotes an invasive macrophage subset and plays a novel regulatory role in MMP-14 proteolytic activity and, therefore, plaque stability, highlighting its therapeutic potential.