Hypobaric hypoxia reduces the amplitude of oscillatory potentials in the human ERG

Janáky, Márta; Grósz, Andor; Tóth, É.; Benedek, Krisztina; Benedek, György

doi:10.1007/s10633-006-9038-5

Cited by 42 publications

(35 citation statements)

References 27 publications

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“…In addition, the reduction in the V max , as determined by the Naka-Rushton analysis of the b-wave, may be attributed to a reduced function in the inner retina. This is in line with previous results demonstrating a reduction of the inner retinal thickness in OIR rodents (Downie et al 2007(Downie et al , 2010Fulton et al 1999;Vessey et al 2011) and confirms the notion that the inner layers of the retina display the highest sensitivity towards circulatory and/or hypoxic challenges (Janaky et al 2007).…”

Section: Electroretinographic Responses and Hypoxia Effectssupporting

confidence: 92%

Protective role of somatostatin receptor 2 against retinal degeneration in response to hypoxia

Monte

Latina

Cupisti

et al. 2012

Naunyn-Schmiedeberg's Arch Pharmacol

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In mouse retinal explants, octreotide, a somatostatin [somatotropin release-inhibiting factor (SRIF)] receptor 2 (sst(2)) agonist, prevents the hypoxia-induced vascular endothelial growth factor upregulation. In mice with oxygen-induced retinopathy (OIR), a model of retinopathy of prematurity, either sst(2) overexpression or octreotide have been found to limit hypoxia-induced angiogenic processes. Here, we investigated whether sst(2) influences retinal degeneration in response to hypoxia in wild-type (WT), sst(1)- and sst(2)-knockout (KO) mice. In retinal explants, we determined the role of sst(2) on apoptotic signals. In control condition, caspase-3 activity and the Bax/Bcl-2 ratio were lower in sst(1)-KO than in WT, but higher in sst(2)-KO than in WT retinas. In all strains, a comparable increase in caspase-3 activity and the Bax/Bcl-2 ratio was observed after hypoxia. The hypoxia-induced increase in apoptotic signals was recovered by octreotide in both WT and sst(1)-KO retinas. To investigate the role of sst(2) on retinal function, we recorded electroretinogram (ERG) in response to light flashes in OIR mice. ERG responses did not differ between WT and KO mice with the exception of oscillatory potentials (OPs) which, in sst(1)-KO mice, displayed much larger amplitude. In all strains, hypoxia drastically reduced a-, b-waves and OPs. In both WT and sst(1)-KO mice, octreotide recovered a- and b-waves, but did not recover OPs in sst(1)-KO mice. Neither apoptotic signals nor ERG was affected by octreotide in sst(2)-KO mice. These results show that sst(2) may protect retinal cells from hypoxia, thus implementing the background to establish potential pharmacological targets based on sst(2) pharmacology.

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Section: Electroretinographic Responses and Hypoxia Effectssupporting

confidence: 92%

Protective role of somatostatin receptor 2 against retinal degeneration in response to hypoxia

Monte

Latina

Cupisti

et al. 2012

Naunyn-Schmiedeberg's Arch Pharmacol

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“…9 -11 Comparable observations have been made on humans during high altitude or simulated hypobaric hypoxia. [12][13][14] In our previous study, we further demonstrated an unequal eccentric distribution of the electroretinographic response to acute hypoxia. 8 Sudden physiological perturbations tend to elicit not only acute but also chronic responses, often of a counterregulatory nature.…”

mentioning

confidence: 61%

The Effect of High- to Low-Altitude Adaptation on the Multifocal Electroretinogram

Kofoed

Sander

Zubieta-Calleja

et al. 2009

Invest. Ophthalmol. Vis. Sci.

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On arrival at sea level, the highlanders had markedly supernormal multifocal electroretinographic amplitudes that continued to increase during the 72-day period of observation where the highlanders' hematocrit normalized. The results suggest that acclimatization after a change in altitude and hence in ambient oxygen tension involves intrinsic retinal mechanisms and that acclimatization was not complete by the end of the study.

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“…The first factor is usually caused by GB, hypotension, atherosclerosis, diabetes, occlusive diseases of the large blood vessels, blood diseases. From local changes are the most important vessels atheromatosis, violations of the vascular endothelium [16,17,18,19].…”

Section: Discussionmentioning

confidence: 99%

Correction of Ischemic Damage to the Retina on Application of Pharmacological Preconditioning of Recombinant Erythropoietin

Shabelnikova¹

2016

RR.P and CP

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Abstract. To study the protective properties of pharmacological preconditioning with recombinant erythropoietin suberitro stimulating dose of 50 IU / kg in the retina of the eye, was the model of retinal ischemia, ischemia with the assessment of the temporary simulation mode of the retina of rats with the instrumental methods of analysis and morphometric studies. The most suitable model was a model 30 minute ischemia with subsequent reperfusion periods of 1 hour to 72 hours. We studied the protective effect preconditioning suberitro stimulating recombinant erythropoietin in a dose of 50 IU/kg, preconditioning distant ischemic and emoxipine 2 mg/kg per rat model of retinal ischemia. In the experiment, it was revealed that the recombinant erythropoietin (50 IU/kg) prevents the development of degenerative retinal layers due to ischemic damage more than distant ischemic preconditioning and emoxipine. The observed protective effect of erythropoietin us with the development of ischemia was confirmed by laser Doppler flowmetry, electroretinography and morphometry. Using suberitro stimulating recombinant erythropoietin in a dose of 50 IU/kg, 30 minutes prior to the pathology simulation eliminates erythropoietic effect, and the lack of positive dynamics in groups with preliminary administration of glibenclamide 5 mg/kg, the key role of ATP-dependent potassium channels in a preconditioning mechanism implementation. Identification and use of pharmacological agents, which have the effect of preconditioning, may be a new approach in the correction and prevention of retinal ischemia, which is the leading element in the pathogenesis of a number of visual pathologies. The possibility of pharmacological preconditioning with erythropoietin ischemic lesions of the retina is essential for the development of anti-ischemic agents for the treatment and prevention of ocular pathologies of ischemic origin.

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Hypobaric hypoxia reduces the amplitude of oscillatory potentials in the human ERG

Abstract: These results appear to support the notion that the inner layers of the retina presumed to be the main source of the OPs, display the highest sensitivity towards circulatory and/or hypoxic challenges.

Cited by 42 publications

References 27 publications

Protective role of somatostatin receptor 2 against retinal degeneration in response to hypoxia

Protective role of somatostatin receptor 2 against retinal degeneration in response to hypoxia

The Effect of High- to Low-Altitude Adaptation on the Multifocal Electroretinogram

Correction of Ischemic Damage to the Retina on Application of Pharmacological Preconditioning of Recombinant Erythropoietin

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