Hypobaric hypoxia impairs spatial memory in an elevation-dependent fashion

Shukitt‐Hale, Barbara; Stillman, Michael J.; Welch, D.I.; Levy, Aharon; Devine, James; Lieberman, Harris R.

doi:10.1016/s0163-1047(05)80023-8

Cited by 80 publications

(38 citation statements)

References 22 publications

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“…To our knowledge, our study is the first reporting that acute and repeated hypoxic exposure enhances performance of adult mice in a water maze. In contrast with our results, other results suggest that hypoxic exposure impairs, or does not affect, the ability of learning and memory in adult and neonatal animals [8,9,32] . This discrepancy could be explained by the differences in the methods for hypoxic exposure and differences in the development stage in which animals were exposed to hypoxia.…”

Section: Discussioncontrasting

confidence: 99%

“…This discrepancy could be explained by the differences in the methods for hypoxic exposure and differences in the development stage in which animals were exposed to hypoxia. For instance, when adult rats were exposed to hypobaric hypoxia at the altitudes of 5,500, 5,950 and 6,400 m, the spatial memory was impaired; the neonatal rats' being exposed to severe hypoxia (8% O 2 ) for 3 h proved to result in impairment in learning ability; when adult mice were exposed to intermittent hypoxia (4 h/day) at the altitudes of 2 or 5 km, the spatial memory was unchanged [8,9,32] .…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown by many reports that hypoxia impairs learning and memory in animals and humans [8,9] , and that intermittent hypoxia can also induce cognitive deficits both in children and adults [10,11] . In contrast to these reports on impairing cognitive ability, it was also presented that neonatal intermittent hypobaric hypoxia exposure enhanced mouse spatial learning and memory ability and that mild HPC prevented impair-315 ment of passive avoidance learning [12,13] .…”

Section: Introductionmentioning

confidence: 99%

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Hypoxic Preconditioning Improves Spatial Cognitive Ability in Mice

et al. 2006

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Although it has been reported in a lot of studies that hypoxic preconditiong could protect the brain from hypoxic/ischemic injury, it is not clear whether hypoxic preconditioning could affect brain functions such as cognitive ability. This work aims at investigating the effect of hypoxic preconditioning on spatial cognitive ability in mice after acute and repeated hypoxic exposures. The mice were randomly divided into 3 groups: a control group in which mice were not exposed to hypoxia (H0) and experimental groups in which mice encountered hypoxia either once (H1) or 4 times (H4). Neural cell adhesion molecule (NCAM) expression, long-term potentiation (LTP) recording and Morris water maze test were used to measure the animals’ cognitive ability. The tolerance time was progressively prolonged as exposure went on. The expression of both NCAM mRNA and NCAM protein as well as the LTP induction rate decreased in group H1, but recovered to control level in group H4. The performance of mice in the maze test was improved in H4 in comparison with that in both H1 and H0. These findings may indicate that spatial cognitive ability is improved in adult mice by their hypoxic preconditioning.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hypoxic Preconditioning Improves Spatial Cognitive Ability in Mice

et al. 2006

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“…For example, when adult rats were exposed to hypobaric hypoxia of altitude 5500, 5950, and 6400 m, the spatial memory was impaired (Shukitt-Hale et al, 1994). Rats exposed to hypoxia (8% O 2 ) for 3 h at P7 showed a deficiency in MWM and T-maze acquisition tasks (Balduini et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…Many reports showed that hypoxia impaired animal's spatial learning (Shukitt-Hale et al, 1994;Almli et al, 2000;Balduini et al, 2000;Ikeda et al, 2001;Row et al, 2002;Simonova et al, 2003;Decker et al, 2003), avoidance task (Clincke and Wauquier, 1984;Viu et al, 2000), and memory consolidation (Sara, 1974;Chleide et al, 1993;Camm et al, 2001;Yonelinas et al, 2002). The study on mountain climbers by Hornbein (1989) revealed a decline in visual long-term memory after ascent.…”

Section: Introductionmentioning

confidence: 99%

Neonatal exposure to intermittent hypoxia enhances mice performance in water maze and 8-arm radial maze tasks

Zhang

Chen

et al. 2005

J. Neurobiol.

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Hypoxia has generally been reported to impair learning and memory. Here we established a hypoxia-enhanced model. Intermittent hypoxia (IH) was simulated at 2 km (16.0% O2) or 5 km (10.8% O2) in a hypobaric chamber for 4 h/day from birth to 1, 2, 3, or 4 week(s), respectively. Spatial learning and memory ability was tested in the Morris water maze (MWM) task at ages of postnatal day 36 (P36)-P40 and P85-89, respectively, and in the 8-arm maze task at P60-68. The long-term potentiation (LTP), synaptic density, and phosphorylated cAMP-responsive element-binding protein (p-CREB) level in the hippocampus were measured in mice at P36 under the IH for 4 weeks (IH-4w). The results showed that IH for 3 weeks (IH-3w) and IH-4w at 2 km significantly reduced the escape latencies of mice at P36-40 in the MWM task with significantly enhanced retention, and this spatial enhancement was further confirmed by the 8-arm maze test in mice at P60-68. The improvement in MWM induced by IH-4w at 2 km was still maintained in mice at P85-89. IH-4w at 2 or 5 km significantly increased amplitude of LTP, the number of synapse, and the p-CREB level in the hippocampus of P36 mice. These results indicated that IH (4 h/day) exposure to neonatal mice at 2 km for 3 or 4 weeks enhanced mice spatial learning and memory, which was related to the increased p-CREB, LTP, and synapses of hippocampus in this model.

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Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study

Chen

Zhang

et al. 2019

Human Brain Mapping

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The study of individuals at high‐altitude (HA) exposure provides an important opportunity for unraveling physiological and psychological mechanism of brain underlying hypoxia condition. However, this has rarely been assessed longitudinally. We aim to explore the cognitive and cerebral microstructural alterations after chronic HA exposure. We recruited 49 college freshmen who immigrated to Tibet and followed up for 2 years. Control group consisted of 49 gender and age‐matched subjects from sea level. Neuropsychological tests were also conducted to determine whether the subjects' cognitive function had changed in response to chronic HA exposure. Surface‐based cortical and subcortical volumes were calculated from structural magnetic resonance imaging data, and tract‐based spatial statistics (TBSS) analysis of white matter (WM) fractional anisotropy (FA) based on diffusion weighted images were performed. Compared to healthy controls, the high‐altitude exposed individuals showed significantly lower accuracy and longer reaction times in memory tests. Significantly decreased gray matter volume in the caudate region and significant FA changes in multiple WM tracts were observed for HA immigrants. Furthermore, differences in subcortical volume and WM integration were found to be significantly correlated with the cognitive changes after 2 years' HA exposure. Cognitive functions such as working memory and psychomotor function were found to be impaired during chronic HA. Differences of brain subcortical volumes and WM integration between HA and sea‐level participants indicated potential impairments in the brain structural modifications and microstructural integrity of WM tracts after HA exposure.

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Hypobaric hypoxia impairs spatial memory in an elevation-dependent fashion

Cited by 80 publications

References 22 publications

Hypoxic Preconditioning Improves Spatial Cognitive Ability in Mice

Hypoxic Preconditioning Improves Spatial Cognitive Ability in Mice

Neonatal exposure to intermittent hypoxia enhances mice performance in water maze and 8-arm radial maze tasks

Combined fractional anisotropy and subcortical volumetric abnormalities in healthy immigrants to high altitude: A longitudinal study

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