Hypoadiponectinemia in lipodystrophic HIV individuals: A metabolic marker of subclinical cardiac damage

Bezante, Gianpaolo; Briatore, L.; Rollando, Daniela; Maggi, Davide; Setti, Maurizio; Ghio, Massimo; Agosti, Sergio; Murdaca, Giuseppe; Balbi, Manrico; Barsotti, Antonio; Cordera, Renzo

doi:10.1016/j.numecd.2008.07.009

Cited by 12 publications

(14 citation statements)

References 29 publications

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“…Low adiponectin levels in our study were also correlated with lipohypertrophy, increased BMI, elevated triglyceride levels, and hypertension, concurrent with prior reports [25,51,54,56]. Additionally, our study noted inverse correlations between adiponectin and duration of HIV infection, cumulative NRTI use, and didanosine.…”

Section: Discussionsupporting

confidence: 90%

“…The first study examined 56 HIV patients and found that a high FRS score was related to hypoadiponectinemia, but no cardiac imaging was performed [25]. The second study (n=45) noted a relationship between low adiponectin levels and coronary flow reserve by echocardiography [56]. Our results are concurrent with these studies suggesting a potential association between hypoadiponectemia and CAD [26,59].…”

Section: Discussionsupporting

confidence: 74%

“…Studies have shown that certain antiretroviral agents (e.g., NRTIs such as stavudine and PIs such as ritonavir) accumulate in adipocytes and down-regulate Peroxisome Proliferator-Activated Receptor-gamma (PPAR-γ) and adiponectin secretion [48][49][50][51][52]. Hence similar to hypoadiponectemia associated with obesity, dysfunctional adipose tissue in the setting of lipodystrophy and antiretroviral agents may lead to reduced secretion of adiponectin, with resultant adverse cardiovascular effects [53][54][55][56][57].…”

Section: Discussionmentioning

confidence: 99%

“…Our study is one of the first to examine the association of adiponectin and CAD, and had a more robust sample size compared to prior studies [25,56]. Additionally we examined several clinical, laboratory, and anthropometric/body measurements in addition to adiponectin levels with CAD.…”

Section: Discussionmentioning

confidence: 99%

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Adiponectin Levels and Coronary Artery Disease among HIV-Infected Men

Norton¹

2013

J AIDS Clinic Res

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Adiponectin Levels and Coronary Artery Disease among HIV-Infected Men

Norton¹

2013

J AIDS Clinic Res

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“…In the HIV population, adiponectin has been found to correlate inversely with visceral adiposity, lipoatrophy, insulin resistance and triglyceride levels 22 . It also appears to correlate with subclinical cardiac disease as assessed by coronary reserve flow in HIV-infected subjects 30 . More recently, a larger study found that HIV-infected men had lower levels of adiponectin compared to HIV-uninfected men, and that these levels were inversely associated with increased coronary stenosis on CT angiography 31 .…”

Section: Discussionmentioning

confidence: 98%

Effect of Recombinant Human Growth Hormone and Rosiglitazone for HIV-Associated Abdominal Fat Accumulation on Adiponectin and other Markers of Inflammation

Leung

Chiu

Kotler

et al. 2016

HIV Clinical Trials

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Background/Objective In a previous report of HIV-infected patients with fat redistribution, we found that recombinant human growth hormone (rhGH) therapy reduced visceral adipose tissue (VAT) but increased insulin resistance, and that the addition of rosiglitazone reversed the negative effects of rhGH on insulin sensitivity. In this study, we sought to determine the effects of recombinant human growth hormone (rhGH) and rosiglitazone therapy on an array of inflammatory and fibrinolytic markers. Methods 72 patients with HIV-associated abdominal obesity and insulin resistance were randomized to treatment with rhGH, rosiglitazone, the combination of rhGH and rosiglitazone, or placebo for 12 weeks. Subjects with plasma and serum samples available at weeks 0 (n = 63) and 12 (n = 46-48) were assessed for adiponectin, C-reactive protein (CRP), homocysteine, interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), fibrinogen, plasminogen activator inhibitor-1 (PAI-1) antigen, and tissue plasminogen activator (tPA) antigen. Results Treatment with both rosiglitazone alone and the combination of rosiglitazone and rhGH for 12 weeks resulted in significant increases in adiponectin levels from baseline. Adiponectin levels did not change significantly in the rhGH alone arm. There were no significant changes in the other biomarkers amongst the different treatment groups. Discussion In this study of HIV-infected patients with altered fat distribution, treatment with rosiglitazone had beneficial effects on adiponectin concentrations, an effect that was also seen with combination rosiglitazone and rhGH. RhGH administration alone, however, did not demonstrate any significant impact on adiponectin levels despite reductions in VAT.

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Impact of inflammatory cytokine and adipokine gene variations in the development of HIV‐associated lipodystrophy

Namdev

Choudhari

Shyamveer

et al. 2023

The Journal of Gene Medicine

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Cytokines affect lipid and glucose metabolism and also alter the body's habitus. They play a role in the development of lipodystrophy syndrome. Adipocytes secrete the pro‐inflammatory cytokines IL‐1, TNF‐α and IL‐6. The plasma cytokine concentration is associated with the percentage and distribution of fat tissue in the body. The metabolic disturbances are strongly associated with increased levels of pro‐inflammatory cytokines (IL‐1, IL‐6 and TNF‐α). Plasma levels of cytokines such as TNF‐α, IL‐6 and leptin were found to be increased while plasma resistin levels were found to be variable in patients suffering from obesity and type II diabetes mellitus. Until now, limited information has been available on the polymorphism of cytokine and adipokine genes in patients of HIV‐associated lipodystrophy (HIVLD), which can contribute to individual variations in susceptibility to metabolic diseases, especially to HIVLD. Hence, we studied the association of cytokine and adipokine gene polymorphisms in various diseases and their impact on HIVLD. We carry out an extensive search using several databases, including PubMed, EMBASE and Google Scholar. The distribution of cytokine and adipokine gene polymorphisms and their expression levels varied among various populations. We examined the variants of cytokine and adipokine genes, which can contribute to individual variations in susceptibility to metabolic diseases, especially to HIVLD. In the current review, we present a brief account of the risk factors of HIVLD, the pathogenesis of HIVLD and the polymorphism of cytokine and adipokine genes in various diseases with special reference to their impact on HIVLD.

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Hypoadiponectinemia in lipodystrophic HIV individuals: A metabolic marker of subclinical cardiac damage

Cited by 12 publications

References 29 publications

Adiponectin Levels and Coronary Artery Disease among HIV-Infected Men

Adiponectin Levels and Coronary Artery Disease among HIV-Infected Men

Effect of Recombinant Human Growth Hormone and Rosiglitazone for HIV-Associated Abdominal Fat Accumulation on Adiponectin and other Markers of Inflammation

Impact of inflammatory cytokine and adipokine gene variations in the development of HIV‐associated lipodystrophy

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