2007
DOI: 10.1161/hypertensionaha.107.086835
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Hypoadiponectinemia as a Predictor for the Development of Hypertension

Abstract: Abstract-Low circulating levels of adiponectin, an adipokine with insulin-sensitizing, antiatherogenic, and antiinflammatory properties, are found in hypertensive patients. Adiponectin replenishment ameliorated hypertension in adiponectin-deficient mice or obese, hypertensive mice with hypoadiponectinemia, suggesting an etiologic role of adiponectin in hypertension. We aimed to determine, in this 5-year prospective study, whether hypoadiponectinemia could predict the development of hypertension in a nondiabeti… Show more

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Cited by 243 publications
(200 citation statements)
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“…Because adiponectin can reduce circulating fatty acid levels via enhanced fatty acid oxidation and reduced fatty acid synthesis [20], hypoadiponectinemia may increase the risk of hypertension in obese subjects through its adverse effects on fatty acid metabolism. Chow et al [21] observed that hypoadiponectinemia associated with hypertension in prospective study.…”
Section: Discussionmentioning
confidence: 98%
“…Because adiponectin can reduce circulating fatty acid levels via enhanced fatty acid oxidation and reduced fatty acid synthesis [20], hypoadiponectinemia may increase the risk of hypertension in obese subjects through its adverse effects on fatty acid metabolism. Chow et al [21] observed that hypoadiponectinemia associated with hypertension in prospective study.…”
Section: Discussionmentioning
confidence: 98%
“…In addition, two prospective Asian studies have shown that hypoadiponectinemia is associated with incident hypertension. Chow et al 15 conducted a 5-year prospective study to examine the association between adiponectin and hypertension in a nondiabetic Chinese cohort. From health insurance data, 391 healthy Japanese men were followed for a period of 6 years in another study, during which 45 of them developed hypertension.…”
Section: Discussionmentioning
confidence: 99%
“…13 Several cross-sectional studies had previously shown an inverse relation between adiponectin levels and BP. 14,15 Recently, Chow et al 6 added another important observation to the relationship between adipose tissue and high BP by demonstrating for the first time an inverse relation between plasma adiponectin concentration and the future development of hypertension. In this case, the control study, which was carried out in a population-based prospective investigation of Chinese subjects, 70 normotensive, nondiabetic subjects who will develop hypertension within the next 5 years were compared with 140 age-matched and sex-matched individuals who remained normotensive at year 5.…”
Section: Discussionmentioning
confidence: 99%
“…5 Adiponectin is a major adipocytokine exclusively synthesized by the adipose tissue. 6 The plasma concentration of adiponectin is decreased in patients with obesity 7 and hypertension. 8 In a recent study, prehypertensives exhibited lower adiponectin values as compared with normotensives, but that study included only lean healthy whites.…”
Section: Introductionmentioning
confidence: 99%