“…Several herbal medicine revealed on array of pre-clinical antidepressant activity. Some antidepressant herbal medicine, such as Hypericum perforatum, Rhodiola rosea (roseroot) and Crocus sativas (Saffron) offer promise for the treatment of depression via known psychopharmacological actions and sometimes antidepressant mechanisms are not as clearly defined as with selective serotonin reuptake inhibitors (SSRIs) (Toda and Morimoto, 2008;Panossian, et al ., 2008;Limpeanchob et al, 2008;Sarris and Kvanagh, 2009;Van Dierman et al ., 2009;Hosseinzadeh and Noraei, 2009;Krishnakumar et al, 2009;Awad et al, 2009;Lopez et al ., 2009;Grundmann et al ., 2009;Sena et al ., 2009;Cao et al, 2010;Cho et al, 2010;Chang and Wang, 2010). Some agents, such as Piper methysticum and H. perforatum in meta-analyses studies revealed significant effects over placebo and comparable effects to synthetic agents (Linde, 2008;Sarris et al, 2010).…”