2010
DOI: 10.1016/j.jep.2010.03.023
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Hypnotic effect of jujubosides from Semen Ziziphi Spinosae

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Cited by 138 publications
(77 citation statements)
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“…One study, in normal rats, has found that the hypnotic effect of jujuboside, one of the active constituents isolated from Ziziphi Spinosae Semen may be influenced by circadian rhythms, and the serotonergic system may enhance the hypnotic effect. In addition, jujuboside may serve as a valuable lead compound for the development of novel hypnotics (Cao et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…One study, in normal rats, has found that the hypnotic effect of jujuboside, one of the active constituents isolated from Ziziphi Spinosae Semen may be influenced by circadian rhythms, and the serotonergic system may enhance the hypnotic effect. In addition, jujuboside may serve as a valuable lead compound for the development of novel hypnotics (Cao et al, 2010).…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies suggest that herbal medicines show promise in managing mild to moderate depression (Dwyer et al, 2011) and isolated plant constituents, such as jujuboside, may prove to be a valuable source of lead compounds for the development of novel hypnotics (Cao et al, 2010).…”
Section: Introductionmentioning
confidence: 99%
“…Decreased sucrose consumption preference predicates anhedonia, the major component of depression in animals. (14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). Some agents, such as Piper methysticum and H. perforatum in meta-analyses studies revealed significant effects over placebo and comparable effects to synthetic agents (26).…”
Section: Discussionmentioning
confidence: 99%
“…Several herbal medicine revealed on array of pre-clinical antidepressant activity. Some antidepressant herbal medicine, such as Hypericum perforatum, Rhodiola rosea (roseroot) and Crocus sativas (Saffron) offer promise for the treatment of depression via known psychopharmacological actions and sometimes antidepressant mechanisms are not as clearly defined as with selective serotonin reuptake inhibitors (SSRIs) (Toda and Morimoto, 2008;Panossian, et al ., 2008;Limpeanchob et al, 2008;Sarris and Kvanagh, 2009;Van Dierman et al ., 2009;Hosseinzadeh and Noraei, 2009;Krishnakumar et al, 2009;Awad et al, 2009;Lopez et al ., 2009;Grundmann et al ., 2009;Sena et al ., 2009;Cao et al, 2010;Cho et al, 2010;Chang and Wang, 2010). Some agents, such as Piper methysticum and H. perforatum in meta-analyses studies revealed significant effects over placebo and comparable effects to synthetic agents (Linde, 2008;Sarris et al, 2010).…”
Section: Discussionmentioning
confidence: 99%