Antidepressant-like activities of Ocimum basilicum (sweet Basil) in the forced swimming test of rats exposed to electromagnetic field (EMF)

Abdoly, Mehdi

doi:10.5897/ajpp11.761

Cited by 17 publications

(4 citation statements)

References 34 publications

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“…In a study of O. basilicum, it was reported that its extract has protective effect in exposed animals to electromagnetic fields induced depression, and i.e. sows antioxidative potency and free radical scavenging activity 44 . In a comparative study O. sanctum (O. tenuiflorum) was found with more protective effect as antidepressant activity than C. sinensis 45 .…”

Section: Locomotion Countmentioning

confidence: 99%

Phytochemical, Antioxidant and Antidepressant Evaluation ofOcimum basilicum,O.tenuiflorum,O. kilimandscharicumGrown in India

Tewari

Pandey

Sah

et al. 2015

Journal of Biologically Active Products from Nature

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Ocimum is used in traditional medicine, as a culinary herb and a well known source of flavouring principle. The antioxidant activity in three Ocimum taxa viz. O. basilicum, O. tenuiflorum, O. kilimandscharicum was determined by DPPH free radical scavenging ability and reducing power assay. Total phenolic, flavonoids and tannins were determined using spectrophotometric technique and comparative antidepressant activity was evaluated using forced swim test. It was observed that all the three species of Ocimum found in western Himalayan region show significant antioxidant and antidepressant activities, however the O. kilimandscharicum was found to have highest antioxidant and antidepressant activity.

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Section: Locomotion Countmentioning

confidence: 99%

Phytochemical, Antioxidant and Antidepressant Evaluation ofOcimum basilicum,O.tenuiflorum,O. kilimandscharicumGrown in India

Tewari

Pandey

Sah

et al. 2015

Journal of Biologically Active Products from Nature

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“…After eight weeks, rats which were fed with O. basilicum extract (1.5 g/kg body weight), showed decreased immobility score (P < 0.001) and increased swimming (P < 0.001), as compared to control group. Hence, basil proved to have CNS activity 42 . Anticonvulsant activity of the essential oil of Ocimum basilicum leaves was reported.…”

Section: Central Nervous System Activitymentioning

confidence: 99%

Ocimum Basilicum: A Review on Phytochemical and Pharmacological Studies

Khair-ul-Bariyah¹,

Ahmed²,

Ikram³

2012

Pak. J. Chem

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Ocimum basilicum is a common herb that is known for its ornamental and therapeutic importance. The chemical constituents which have been isolated from the plant include terpenoids, alkaloids, flavonoids, tannins, saponin glycosides and ascorbic acid. It has been reported to be hepatoprotective, immunomodulatory, antihyperglycemic, hypolipidemic, antitoxic, anti-inflammatory, antibacterial and antifungal. The present review is aimed to cover the phytochemical study and pharmacological investigations on this important medicinal herb.

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“…Daun kemangi memiliki aktifitas antidepresan terbesar adalah 1,5 mg/kgBB dalam penelitian yang berjudul antidepressant-like activities of ocimum basilicum (sweet basil) in the forced swimming test of rats exposed to electromagnetic field (emf) [14] . Perbedaan dari penelitian ini dengan penelitian sebelumnya adalah penelitian ini dilakukan kombinasi antara biji pala dan daun kemangi, serta pembutannya dengan metode infusa.…”

Section: Hasil Dan Pembahasanunclassified

Efek Antidepresan Kombinasi Infusa Biji Pala (Myristica fragrans) dan Daun Kemangi (Ocimum basilicum) pada Mencit Jantan Putih (Mus musculus)

Istriningsih

Khoirunnisa

Kurnianingtyas

2018

JIPP

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AbstrakDepresi adalah keadaan murung setiap orang yang mengalami kekecewaan hebat atau kehilangan pribadi dengan sendirinya menjadi murung. Pada penelitian telah terbukti bahwa biiji pala mengandung senyawa miristin dan daun kemangi mengandung senyawa eugenol yang mempunyai efek antidepresan. Tujuan penelitian ini yaitu untuk mengetahui efek antidepresan kombinasi infusa biji pala dan daun kemangi serta mengetahui konsentrasi kombinasi yang paling baik pada mencit putih jantan. Biji pala dan daun kemangi diekstraksi dengan metode infusa. Dosis biji pala yang digunakan 10mg/KgBB dan daun kemangi 1,5g/KgBB dikombinasi dengan konsentrasi (1:1), konsentrasi (1:5) dan konsentrasi (5:1). Kontrol negatif menggunakan akuades dan kontrol positif menggunakan amitriptilin. Pengujian antidepresan pada mencit putih jantan menggunakan metode forced swimming test yang dilakukan selama 10 hari dengan durasi setiap harinya 8 menit, pada hari ke-11 dilakukan pemberian obat dan diukur waktu imobilitasnya. Data pengujian antidepresan dianalisis menggunakan metode kruskalwallis dan mann-whitney. Hasil waktu imobilitas perbandingan infusa biji pala dan daun kemangi (1:1) lebih singkat dibandingkan dengan perbandingan lainnya. Semakin singkat waktu imobilitas maka semakin baik daya antidepresannya. Pada uji kruskal-wallis menunjukan ada perbedaan bermakna dengan nilai signifikan 0,003<0,05 sehingga dilanjutkan uji mann-whitney. Pada uji mann-whitney P3 dengan Kdan K+ dengan P1 menunjukan adanya perbedaan pada setiap kelompoknya.

show abstract

Antidepressant-like activities of Ocimum basilicum (sweet Basil) in the forced swimming test of rats exposed to electromagnetic field (EMF)

Cited by 17 publications

References 34 publications

Phytochemical, Antioxidant and Antidepressant Evaluation ofOcimum basilicum,O.tenuiflorum,O. kilimandscharicumGrown in India

Phytochemical, Antioxidant and Antidepressant Evaluation ofOcimum basilicum,O.tenuiflorum,O. kilimandscharicumGrown in India

Ocimum Basilicum: A Review on Phytochemical and Pharmacological Studies

Efek Antidepresan Kombinasi Infusa Biji Pala (Myristica fragrans) dan Daun Kemangi (Ocimum basilicum) pada Mencit Jantan Putih (Mus musculus)

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