Hyperviscosity syndrome in ovariectomized rats

Plotnikova, A. M.; Shulgau, Zarina; Плотникова, Т. М.; Алиев, О. И.; Borovskaya, T. G.

doi:10.1007/s10517-008-0216-1

Cited by 4 publications

(2 citation statements)

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“…In the oscillatory potential analysis, we found evidence of photoreceptor and interneuron declines after the ovariectomy procedure, as observed in OP1-2 amplitude decreases [63,64]. However, the increase in OP3 amplitudes after ovariectomy may suggest both the stimulation of retinal glia and an impact on the retinal blood flow related to the differences in the rheological features of blood and vascular resistances in postmenopausal animals [11,[65][66][67].…”

Section: Discussionmentioning

confidence: 55%

Surgical Menopause Impairs Retinal Conductivity and Worsens Prognosis in an Acute Model of Rat Optic Neuropathy

Olakowska

Rodak

Pacwa

et al. 2022

Cells

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Deficiency of estradiol during the menopausal period is an important risk factor for neurodegenerative diseases, including various optic neuropathies. The aim of this study was to evaluate the impact of surgical menopause on the function and survival ratio of RGCs in the rat model of ONC (optic nerve crush). We used eight-week-old female Long Evans rats, divided into two main groups depending on the time between ovariectomy procedure (OVA) and euthanasia (two weeks vs. seven weeks), and subgroups—OVA, OVA + ONC, or ONC. Retinal function was assessed with electroretinography (ERG). RGC loss ratio was evaluated using immunolabelling and counting of RGCs. Seven weeks after OVA, the menopause morphologically affected interneurons but not RGC; however, when the ONC procedure was applied, RGCs appeared to be more susceptible to damage in case of deprivation of estrogens. In our analysis, PhNR (photopic negative responses) were severely diminished in the OVA + ONC group. A deprivation of estrogens in menopause results in accelerated retinal neurodegeneration that firstly involves retinal interneurons. The lack of estrogens increases the susceptibility of RGCs to insults.

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Section: Discussionmentioning

confidence: 55%

Surgical Menopause Impairs Retinal Conductivity and Worsens Prognosis in an Acute Model of Rat Optic Neuropathy

Olakowska

Rodak

Pacwa

et al. 2022

Cells

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“…In previous animal experiments gonadectomy as well as sex-hormone substitution had effect on hemorheological variables [24,27,31]. In rats ovariectomy was shown to increase hematocrit, fibrinogen concentration, red blood cell aggregation and blood viscosity [31].…”

Section: Discussionmentioning

confidence: 94%

Following-up hemorheological consequences of gonadectomy in male and female rats

Németh

Kiss

Magyar

et al. 2012

Clinical Hemorheology and Microcirculation

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Growing number of clinical and experimental data reflect to the gender differences of hemorheological parameters. However, little is known about the potential hemorheological effect of gonadectomy and consequent changes in sex hormone concentration. Adult, sameaged male and female rats were involved in the study. In control male and female group no surgical intervention was performed. In gonadectomized (GoE) male and female groups bilateral orchidectomy or ovariectomy were completed. Body weight measurement and blood sampling were carried out in the 1 st , 2 nd and 3 rd postoperative months. The GoE females had significant bodyweight augmentation and their plasma estrogen concentration decreased by 40-45% by the 1 st postoperative month, while in males the testosterone level was not detectable after gonadectomy. Leukocyte and platelet counts moderately increased in GoE males. Elongation index values of erythrocytes slightly decreased in both genders after gonadectomy, showing converging values. Erythrocyte aggregation index values of GoE females significantly raised by the 2 nd month. It can be concluded that gonadectomy in rats resulted in alteration (dominantly impairment) of blood micro-rheological parameters, by different manner in males and females. Supposedly decrease in estrogen can cause more expressed hemorheological changes than the cessation of testosterone.

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