Hyperuricosuric calcium nephrolithiasis

Sorensen, Carsten M.; Chandhoke, Paramjit S.

doi:10.1016/s0889-8529(02)00038-5

Cited by 30 publications

(21 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…46 There is therefore no clear consensus on dietary purine restriction, so moderation is probably the appropriate advice, 6 particularly in view of the fact that low purine diets are non-palatable and compliance with them is poor. 47 …”

Section: Low Purine Dietmentioning

confidence: 99%

Best Practice No 181: Table 1

Reynolds

2005

J Clin Pathol

View full text Add to dashboard Cite

Renal stones have afflicted humans for millennia but there is still no solution to this problem. This review discusses the laboratory and metabolic aspects of the clinical management of patients with renal stones, both primary and secondary in origin. First, non-pharmacological interventions such as increased fluid intake, decreased protein consumption, dietary changes in sodium, calcium, oxalate, potassium, purine, vitamins, and essential fatty acids are considered. Then specific pharmacological treatment to modify urine calcium, oxalate, urate, citrate, and acidity are considered. Finally, more unusual types of stone are examined.

show abstract

Section: Low Purine Dietmentioning

confidence: 99%

Best Practice No 181: Table 1

Reynolds

2005

J Clin Pathol

View full text Add to dashboard Cite

show abstract

“…Hyperuricosuria imparts several effects on the urinary milieu that promote calcium stone formation [23]. The primary mechanism is the salting-out phenomenon by which uric acid or sodium urate enhances calcium oxalate precipitation by lowering its solubility [24].…”

Section: Calcium Stonesmentioning

confidence: 99%

Nephrolithiasis in children

2005

View full text Add to dashboard Cite

A metabolic etiology is the most common cause for pediatric kidney stones. Appropriate evaluation of affected children should include assessment of stone type, if available, and assessment of predisposing factors in all cases. This review discusses the metabolic disorders that lead to nephrolithiasis with respect to the development of calcium, uric acid, struvite, and cystine stones. Environmental and hereditary factors are summarized to provide a guide in the evaluation of pediatric stone formers.

show abstract

“…[33][34][35] UA could function as a nidus to induce the generation, precipitation, and aggregation of CaOx crystals. 36 Moreover, UA crystals, which are better nucleating agents than mucoproteins (glycoprotein) and cell debris, can induce the development of COM as a heterogeneous nucleating agent. 14 Grover et al 37 studied the concentration of dissolved urate that promoted the crystallization of CaOx from urine.…”

Section: Eds Analysis Of Urinary Crystallitesmentioning

confidence: 99%

Nanouric acid or nanocalcium phosphate as central nidus to induce calcium oxalate stone formation: a high-resolution transmission electron microscopy study on urinary nanocrystallites

Gao¹,

Xue²,

Xu³

et al. 2014

IJN

View full text Add to dashboard Cite

Purpose This study aimed to accurately analyze the relationship between calcium oxalate (CaOx) stone formation and the components of urinary nanocrystallites. Method High-resolution transmission electron microscopy (HRTEM), selected area electron diffraction, fast Fourier transformation of HRTEM, and energy dispersive X-ray spectroscopy were performed to analyze the components of these nanocrystallites. Results The main components of CaOx stones are calcium oxalate monohydrate and a small amount of dehydrate, while those of urinary nanocrystallites are calcium oxalate monohydrate, uric acid, and calcium phosphate. The mechanism of formation of CaOx stones was discussed based on the components of urinary nanocrystallites. Conclusion The formation of CaOx stones is closely related both to the properties of urinary nanocrystallites and to the urinary components. The combination of HRTEM, fast Fourier transformation, selected area electron diffraction, and energy dispersive X-ray spectroscopy could be accurately performed to analyze the components of single urinary nanocrystallites. This result provides evidence for nanouric acid and/or nanocalcium phosphate crystallites as the central nidus to induce CaOx stone formation.

show abstract

Hyperuricosuric calcium nephrolithiasis

Cited by 30 publications

References 33 publications

Best Practice No 181: Table 1

Best Practice No 181: Table 1

Nephrolithiasis in children

Nanouric acid or nanocalcium phosphate as central nidus to induce calcium oxalate stone formation: a high-resolution transmission electron microscopy study on urinary nanocrystallites

Contact Info

Product

Resources

About