Hyperuricemia in Hyperparathyroidism

Mintz, Daniel H.; Canary, John J.; Carreon, G G; Kyle, Laurence H.

doi:10.1056/nejm196107202650302

Cited by 95 publications

(35 citation statements)

References 13 publications

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“…Hyperuricaemia and gout are commonly seen in patients with primary hyperparathyroidism [85], even when the gout can be shown to be due to urate crystal formation in synovial fluid and not to calcium pyrophosphate deposition [65], This hyperuricaemia is sometimes, but not always, reversible following parathyroidectomy [108], Nephrocalcinosis is a not infrequent finding in such cases and it appears likely that the hyperuricaemia is attribut able to varying combinations of impairment of glomerular filtration rate and of damage to renal tubules, probably due to microscopic deposition of calcium [108]. The administration of parathormone to healthy subjects does not produce any significant change in urate excretion [111],…”

Section: Hyperparathyroidismmentioning

confidence: 99%

Abnormal Renal Urate Homeostasis in Systemic Disorders

Emmerson

Ravenscroft

1975

Nephron

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Abnormalities of renal handling of urate occur in a wide variety of physiological and pathological conditions and are mediated by factors including renal blood flow, glomerular filtration rate, urine flow rate, urinary constituents, metabolites, hormones and drugs. The determination of the aetiological factors in each abnormal situation is complex and the problem is discussed in relation to a variety of conditions including renal tubular disorders and metal intoxications, hypertension, toxaemia of pregnancy, glycogen storage disease, fructose administration, hereditary fructose intolerance, as well as obesity, regular alcohol consumption and hyperlipoproteinaemia. Apart from those diseases, usually genetically determined, which are associated with excessive production of urate, the most common causes of hyperuricaemia act at a renal level and result in a reduction in the net renal excretion of urate.

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Section: Hyperparathyroidismmentioning

confidence: 99%

Abnormal Renal Urate Homeostasis in Systemic Disorders

Emmerson

Ravenscroft

1975

Nephron

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“…In the study by Mintz [2], parathyroidecto my per se did not lower raised levels of serum urate. However, the highest serum calcium levels were seen in their hyperuricemia pa tients.…”

Section: Discussionmentioning

confidence: 76%

“…The main symptoms at the time of referral were renal (14). skele tal (4), abdominal (3), and mental (2). No patient was completely asymptomatic.…”

Section: Methodsmentioning

confidence: 99%

Hyperuricemia and Hypertension in Primary Hyperparathyroidism

Haddad¹,

Berg²,

Farah

et al. 1992

Med Principles Pract

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Serum urate levels were studied in 18 patients with primary hyperparathyroidism (pHPT) and in 36 controls (group 2) matched for age, sex, nationality and blood pressure. These two groups were compared with general surgical inpatients (group 3). The prevalence of hyperuricemia was markedly higher in the pHPT patient group (especially for men) than in the other two groups [44,17 and 9%, respectively; p < 0.05 and < 0.001]. The prevalence of hypertension was markedly higher in the pHPT patient group (66.7%) than in the surgical inpatients [15%; p < 0.0001]. Five of the 9 male patients had both hypertension and hyperuricemia, the pathogenesis of which may be related to the action of hypercalcemia on renal functions. As the prevalence of hypertension and hyperuricemia were markedly higher than previously noted, it is suggested that more attention should be paid to blood pressure, serum urate and renal function in patients with primary hyperparathyroidism, in order to improve diagnosis and therapy.

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“…There is convincing evidence that the association between hyperuricemia and IiyI'erparatIiyroidism is more than incidental. hlintz et a1 (47) found 4 patients with high serum urate values among 8 with liyperparatliyroitlisin, antl Scott et a1 (48) reported that 11 of 18 (61%) antl 5 of 11 (45y0) had clinical gout. There is no single mechanism to explain the abnormalities in uric acid metabolism; but it has been shown that parathyroid hormone is not a primary causative factor and that most patients Hypoparathyroidism.…”

Section: Endocrine and Metabolicmentioning

confidence: 99%

Disorders associated with hyperuricemia

Smyth

1975

Arthritis & Rheumatism

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Hyperuricemia in Hyperparathyroidism

Cited by 95 publications

References 13 publications

Abnormal Renal Urate Homeostasis in Systemic Disorders

Abnormal Renal Urate Homeostasis in Systemic Disorders

Hyperuricemia and Hypertension in Primary Hyperparathyroidism

Disorders associated with hyperuricemia

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