Hyperuricemia as a risk factor on cardiovascular events in Taiwan: The Chin-Shan Community Cardiovascular Cohort Study

Chien, Kuo–Liong; Hsu, Hsiu-Ching; Sung, Fung‐Chang; Su, Ta‐Chen; Chen, Ming-Fong; Lee, Yuan‐Teh

doi:10.1016/j.atherosclerosis.2005.01.018

Cited by 104 publications

(117 citation statements)

References 32 publications

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“…[20][21] Briefly, all venous blood samples drawn after a 12-h overnight fast were immediately refrigerated and transported within 6 h to the National Taiwan University Hospital. Serum samples were then stored at -70 1C before batch assay for levels of total cholesterol, triglycerides and high-density lipoprotein cholesterol.…”

Section: Measurement Of Biochemical Markersmentioning

confidence: 99%

Prediction models for the risk of new-onset hypertension in ethnic Chinese in Taiwan

Chien

Hsu

et al. 2010

J Hum Hypertens

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Prediction model for hypertension risk in Chinese is still lacking. We aimed to propose prediction models for new-onset hypertension for ethnic Chinese based on a prospective cohort design on community, which recruited 2506 individuals (50.8% women) who were not hypertensive at the baseline . Total 1029 cases of new-onset hypertension developed during a median of 6.15 (interquartile range, 4.04-9.02) years of followup. In the clinical model, gender (2 points), age (8 points), body mass index (10 points), systolic blood pressure (19 points) and diastolic blood pressure (7 points) were assigned. The biochemical measures, including white blood count (3 points), fasting glucose (1 point), uric acid (3 points), additional to above clinical variables, were constructed. The areas under the receiver operative characteristic curves (AUCs) were 0.732 (95% confidence interval (CI), 0.712-0.752) for the point-based clinical model and 0.735 (95% CI, 0.715-0.755) for the point-based biochemical model. The coefficient-based models had a good performance (AUC, 0.737-0.741). The point-based clinical model had a similar net reclassification improvement as the coefficient-based clinical model (P ¼ 0.30), and had a higher improvement than the point-based biochemical model (P ¼ 0.015). We concluded that the point-based clinical model could be considered as the first step to identify high-risk populations for hypertension among Chinese.

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Section: Measurement Of Biochemical Markersmentioning

confidence: 99%

Prediction models for the risk of new-onset hypertension in ethnic Chinese in Taiwan

Chien

Hsu

et al. 2010

J Hum Hypertens

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“…Details of this cohort study have been published previously (10)(11)(12). Briefly, the Chin-Shan Community Cardiovascular Cohort Study began in 1990 by recruiting 1,703 men and 1,899 women >35 years old, homogeneous in Chinese ethnicity, and living in the Chin-Shan township 30 km north of metropolitan Taipei, Taiwan.…”

Section: Study Design and Study Populationmentioning

confidence: 99%

Apolipoprotein B and non-high density lipoprotein cholesterol and the risk of coronary heart disease in Chinese

Chien

Hsu

et al. 2007

Journal of Lipid Research

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The aim of our study was to compare apolipoprotein B (apoB), non-high density lipoprotein cholesterol (nonHDL-C), low density lipoprotein cholesterol (LDL-C), and other lipid markers as predictors of coronary heart disease (CHD) in Chinese. Overall, 122 individuals developed CHD during a median 13.6 years of follow-up in 3,568 adult participants from a community-based cohort. The multivariate relative risk of CHD in the highest quintile compared with the lowest quintile was 2.74 [95% confidence interval (CI), 1.45-5.19] for apoB, 1.98 (95% CI, 1.00-3.92) for nonHDL-C, and 1.86 (95% CI, 1.00-3.49) for LDL-C (all tests for trend, P , 0.05). ApoB also had the highest receiver operator characteristic curve area (0.63; 95% CI, 0.58-0.68) in predicting CHD. When apoB and nonHDL-C were mutually adjusted, only apoB was predictive; the relative risk was 2.80 (95% CI, 1.31-5.96; P 5 0.001) compared with 1.09 (95% CI, 0.49-2.40; P 5 0.75) for nonHDL-C. Compared with the lowest risk, participants with the highest apoB and total cholesterol/HDL-C had a 3-fold increased risk of developing CHD (relative risk 5 3.21; 95% CI, 1.45-7.14). These data provide strong evidence that apoB concentration was a better predictor of CHD than other lipid markers in Chinese

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“…(14) The prevalence of coronary heart disease is lower in Taiwan in comparison with other studies. (15,16) Third, there was a high prevalence of hyperkalemia in our study population. Those patients without hyperkalemia were more likely to achieve sustained ROSC.…”

Section: Discussionmentioning

confidence: 71%

Successful resuscitation of out of hospital cardiac arrest patients in the emergency department

Chen

Wang

Weng

et al. 2011

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Hyperuricemia as a risk factor on cardiovascular events in Taiwan: The Chin-Shan Community Cardiovascular Cohort Study

Cited by 104 publications

References 32 publications

Prediction models for the risk of new-onset hypertension in ethnic Chinese in Taiwan

Prediction models for the risk of new-onset hypertension in ethnic Chinese in Taiwan

Apolipoprotein B and non-high density lipoprotein cholesterol and the risk of coronary heart disease in Chinese

Successful resuscitation of out of hospital cardiac arrest patients in the emergency department

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