Hyperuricemia and metabolic syndrome in children with overweight and obesity

Modino, Soralla Civantos; Armas, María Guadalupe Guijarro de; Mejías, Susana Monereo; Martínez, July Maribel Montaño; Bolaños, Paloma Iglesias; Viveros, María Merino; Quesada, Jose María Ladero

doi:10.1016/j.endoen.2012.06.007

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…Recent studies also show a higher prevalence of metabolic syndrome in people with hyperuricaemia 11‐13 . Hyperuricaemia is a laboratory disorder that is more common in children, but because the diagnostic value of uric acid alone is low, paediatricians often do not examine its serum level 14 . The results of some studies indicate a strong relationship between uric acid levels and metabolic syndrome in adults and children and have suggested various mechanisms to justify this relationship 11,15 …”

Section: Background and Objectivesmentioning

confidence: 99%

Investigating the relationship between serum uric acid to high‐density lipoprotein ratio and metabolic syndrome

Yazdi

Baghaei

Baniasad

et al. 2021

Endocrino Diabet & Metabol

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Aims This study aimed to determine a parameter to more easily diagnose metabolic syndrome and predict its probability of occurrence in high‐risk individuals. Methods In this cross‐sectional study, data related to the study population in the Kerman Coronary Artery Disease Risk Factor Study (KERCADRS) were examined. Subjects were divided into two groups with and without metabolic syndrome, and the relevant factors such as the ratios of uric acid to high‐density lipoprotein (HDL) (UHR) in these two groups were compared, and the best cut‐off point was determined. Results Data related to 817 people including 96 people with metabolic syndrome and 721 people without metabolic syndrome were analysed. The mean UHR was significantly higher in patients with metabolic syndrome (14.76 ± 6.33%) compared with those without metabolic syndrome (10.0 ± 3.10%) (p < .001). People with high UHR are 2.9 times more at risk of metabolic syndrome and the best cut‐off point was 9.50% with 86% sensitivity and 55% specificity. Conclusions According to our study, UHR is also helpful in diagnosing metabolic syndrome and can also be used to screen people at risk for metabolic syndrome.

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Section: Background and Objectivesmentioning

confidence: 99%

Investigating the relationship between serum uric acid to high‐density lipoprotein ratio and metabolic syndrome

Yazdi

Baghaei

Baniasad

et al. 2021

Endocrino Diabet & Metabol

View full text Add to dashboard Cite

show abstract

“…Hyperuricemia or high serum uric acid (SUA) levels have been linked to obesity, 1,2 fatty liver, type 2 diabetes, 3 and renal injury 4 . Moreover, research has indicated a contributory role of uric acid (UA) in metabolic syndrome, which is characterized by dyslipidemia, insulin resistance, and hypertension 5 .…”

Section: Introductionmentioning

confidence: 99%

Hyperuricemia induces lipid disturbances mediated by LPCAT3 upregulation in the liver

Liu

Sun

et al. 2020

FASEB j.

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Potential underlying molecular mechanisms for uric acid‐induced lipid metabolic disturbances had not been elucidated clearly. This study investigated the effects and underlying mechanisms of uric acid on the development of lipid metabolic disorders. We collected blood samples from 100 healthy people and 100 patients with hyperuricemia for whom serum lipid analysis was performed. Meanwhile, a mouse model of hyperuricemia was generated, and lipidomics was performed on liver tissues, comparing control and hyperuricemia groups, to analyze lipid profiles and key metabolic enzymes. Uric acid directly induced serum lipid metabolic disorders in both humans and mice based on triglycerides, total cholesterol, and low‐density lipoprotein cholesterol. Through lipidomic analysis, 46 lipids were differentially expressed in hyperuricemic mouse livers, and the phosphatidylcholine composition was altered, which was mediated by LPCAT3 upregulation. High‐uric acid levels‐induced p‐STAT3 inhibition and SREBP‐1c activation in vivo and in vitro. Moreover, LPCAT3‐knockdown significantly attenuated uric acid‐induced p‐STAT3 inhibition, SREBP‐1c activation, and lipid metabolic disorders in L02 cells. In conclusion, uric acid induces lipid metabolic disturbances through LPCAT3‐mediated p‐STAT3 inhibition and SREBP‐1c activation. LPCAT3 could be a key regulatory factor linking hyperuricemia and lipid metabolic disorders. These results might provide novel insights into the clinical treatment of hyperuricemia.

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Prevalence of prediabetes and its comorbidities in the Mexican pediatric population

et al. 2021

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Hyperuricemia and metabolic syndrome in children with overweight and obesity

Cited by 3 publications

References 25 publications

Investigating the relationship between serum uric acid to high‐density lipoprotein ratio and metabolic syndrome

Investigating the relationship between serum uric acid to high‐density lipoprotein ratio and metabolic syndrome

Hyperuricemia induces lipid disturbances mediated by LPCAT3 upregulation in the liver

Prevalence of prediabetes and its comorbidities in the Mexican pediatric population

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