Investigating the relationship between serum uric acid to high‐density lipoprotein ratio and metabolic syndrome

Abstract

Aims This study aimed to determine a parameter to more easily diagnose metabolic syndrome and predict its probability of occurrence in high‐risk individuals. Methods In this cross‐sectional study, data related to the study population in the Kerman Coronary Artery Disease Risk Factor Study (KERCADRS) were examined. Subjects were divided into two groups with and without metabolic syndrome, and the relevant factors such as the ratios of uric acid to high‐density lipoprotein (HDL) (UHR) in these two groups were compared, and the best cut‐off point was determined. Results Data related to 817 people including 96 people with metabolic syndrome and 721 people without metabolic syndrome were analysed. The mean UHR was significantly higher in patients with metabolic syndrome (14.76 ± 6.33%) compared with those without metabolic syndrome (10.0 ± 3.10%) (p < .001). People with high UHR are 2.9 times more at risk of metabolic syndrome and the best cut‐off point was 9.50% with 86% sensitivity and 55% specificity. Conclusions According to our study, UHR is also helpful in diagnosing metabolic syndrome and can also be used to screen people at risk for metabolic syndrome.

Association between the uric acid to high density lipoprotein cholesterol ratio and alanine transaminase in Chinese short stature children and adolescents: A cross-sectional study

“…Furthermore, UHR, as a novel marker of metabolic syndrome ( 36 ), has been used to assess type 2 diabetes mellitus ( 16 , 26 ), hepatic steatosis ( 37 ), Hashimoto’s thyroiditis ( 38 ), and the control of MAFLD ( 17 ). UHR was also reported to be associated with poor collateral circulation in chronic total occlusion (CTO) patients and to have important predictive value for cardiovascular mortality in patients living on peritoneal dialysis ( 39 , 40 ).…”

Predictive Value of Serum Uric Acid to HDL Cholesterol Ratio for Incident Ischemic Heart Disease in Non-Diabetic Koreans

“…Previous studies have reported that UHR is useful for predicting metabolic syndrome. Kocak et al reported that serum UHR is a valuable predictor of metabolic syndrome in Turkish people with diabetes [ 21 ], while Yazdi et al reported that UHR could screen or diagnose metabolic syndrome risks in Iranians without diabetes [ 22 ]. Aktas et al have suggested that UHR can be used for diabetes control evaluations in men with diabetes [ 15 ].…”

Hyperuricaemia and its association with other risk factors for cardiovascular diseases: A population‐based study

“…Due to the increasing prevalence of hyperuricaemia, it should be considered as an important health issue. So far, several studies have emphasized the relationship between the presence of hyperuricaemia and cardiovascular risk factors, including hypertension and metabolic syndrome [10][11][12] as in a recent crosssectional study; Yazdi et al 13 showed that the ratio of uric acid to high-density lipoprotein (HDL) cholesterol is significantly higher in people with metabolic syndrome than in healthy individuals. Despite the similarity of the results of the present study with previous studies, there are also differences.…”