Hypertrophic pulmonary osteoarthropathy on bone scintigraphy and 18F-fluorodeoxyglucose positron emission tomography/computed tomography in a patient with lung adenocarcinoma

Cengiz, Arzu; Eren, Mine Şencan; Polatlı, Mehmet; Yürekli, Yakup

doi:10.4103/0972-3919.158535

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…Bone scintigraphy is the most sensitive test showing periosteal involvement. Characteristic findings on bone scans are bilateral symmetrical linear uptake of the tracer along the cortical margins of the long bones, which is also known as tram line or double stripe sign [6, 16].…”

Section: Discussionmentioning

confidence: 99%

Hypertrophic pulmonary osteoarthropathy: an unusual presentation

Kumari

Yeung

Medani

et al. 2018

Rheumatology Advances in Practice

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Objectives Hypertrophic pulmonary osteoarthropathy (HPOA) is a syndrome characterized by the triad of periostitis, digital clubbing and painful arthropathy of the large joints, especially involving the lower limbs. HPOA without clubbing of the digits is considered an incomplete form of HPOA and has been rarely reported. We are presenting here a case of HPOA without clubbing in a patient with lung cancer. Methods A 52-year-old female active smoker presented with a complaint of multiple joint pains with associated morning stiffness, swelling and weight loss for 3 months. On examination, the patient had tenderness to palpation over the anterior shin, but no obvious clubbing was noted. X-rays of the lower extremities revealed periosteal thickening compatible with HPOA. Results A bone scan showed increased uptake along the periosteum and cortex of the long bones. In view of her smoking history and weight loss, a chest X-ray was done that revealed an upper lung mass. A diagnosis of lung carcinoma was made on biopsy. Conclusion Our case demonstrates that the unusual finding of HPOA in the absence of clubbing is a rare entity and can often be missed. Once diagnosed, a prompt search of other associated conditions should be conducted.

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Section: Discussionmentioning

confidence: 99%

Hypertrophic pulmonary osteoarthropathy: an unusual presentation

Kumari

Yeung

Medani

et al. 2018

Rheumatology Advances in Practice

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“…Sedangkan pemeriksaan rontgen genu dan vertebra lumbal menunjukkan kesan suatu osteoatritis. 9,10 Terapi pada HPO adalah pengangkatan lesi tumor primer. Pada kasus karsinoma paru stadium lanjut dimana pengangkatan tumor sulit dilakukan maka dilakukan terlebih dahulu kemoterapi atau radiasi eksterna.…”

Section: No 1 2017unclassified

Hypertrophic pulmonary osteoarthropathy with primary lung cancer

Kurniawati

Kartamihardja

2017

MKA

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Hipertrophic Pulmonary Osteoarthropathy (HPO) merupakan sindrom paraneoplastik yang disebabkan oleh kelainan pada paru-paru. Angka kejadian HPO sangat rendah yaitu kurang dari 1%, dimana penyebab yang tersering (90%) adalah karsinoma bronkogenik. Gambaran klinis HPO timbul akibat kelainan sistemik pada sendi dan jaringan lunak berupa pembengkakan pada jari-jari, pembentukan tulang baru terutama pada tulang panjang ekstremitas bawah, serta gambaran menyerupai artristis pada sendi dan jaringan periartikuler (pergelangan kaki, lutut, pergelangan tangan dan siku). Beberapa penelitian telah melaporkan manfaat sidik tulang (bone scintigraphy) untuk penegakkan diagnosis dan penilaian pasca terapi pada HPO. Sidik tulang selain untuk menegakkan diagnosis dan mengetahui adanya metastasis, juga dapat menggambarkan secara lebih jelas keberadaan dan luasnya aktivitas sub-periosteal dibandingkan pemeriksaan radiologi. Berikut dilaporkan kasus HPO yang awalnya didiagnosis sebagai osteoarthritis dari pemeriksaan radiologi, selanjutnya didiagnosis dengan karsinoma bronkogenik dengan HPO dari pemeriksaan sidik tulang.

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Rheumatologic Manifestations of CF

Reis

White

2020

Respiratory Medicine

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Hypertrophic pulmonary osteoarthropathy on bone scintigraphy and 18F-fluorodeoxyglucose positron emission tomography/computed tomography in a patient with lung adenocarcinoma

Cited by 4 publications

References 14 publications

Hypertrophic pulmonary osteoarthropathy: an unusual presentation

Hypertrophic pulmonary osteoarthropathy: an unusual presentation

Hypertrophic pulmonary osteoarthropathy with primary lung cancer

Rheumatologic Manifestations of CF

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