Hypertrophic pulmonary osteoarthropathy in Hodgkin's disease. Reversal with chemotherapy

Abstract

A case of nodular sclerosis Hodgkin's disease, stage IVB, with lung involvement and hypertrophic pulmonary osteoarthropathy (HPOA), was treated with quadruple cytotoxic chemotherapy. The pulmonary lesions, which were thin walled cavities, and the lymphadenopathy resolved completely after two courses of chemotherapy. The clubbing and all evidence of periosteal new bone formation disappeared after six courses of treatment. Complete reversal of the syndrome by chemotherapy has not been previously described. A literature review revealed 13 more cases of Hodgkin's disease associated with HPOA. The syndrome occurred for the first time at the time of diagnosis of Hodgkin's disease in 11 cases, and at recurrence in two. Tha majority of patients had advanced disease (Stage IIIB or IV). Mediastinal involvement was present in all 12 cases for which data were given; lung involvement was present in six cases and pleural involvement in three. Three cases were of the nodular sclerosis type, and one of the lymphocyte-depletion type. The HPOA syndrome in young patients with malignancy is indicative of tumors other than primary bronchial carcinomas.

Reversible digital clubbing in acute myeloid leukaemia

“…Following successful treatment of the primary disorder, finger clubbing has been known to reverse. [2][3][4] Finger clubbing has not been previously reported in association with acute myeloid leukaemia but two cases associated with chronic lymphocytic leukaemia have been documented.35 A case of acute myeloid leukaemia with marked finger and toe clubbing, and a likely intrathoracic granulocytic sarcoma at presentation is described.…”

Comparative study of solitary thin-walled cavity lung cancer with computed tomography and pathological findings

“…In this study, the definition of solitary thin-walled cavity is that cavity lesion filled with air and it has a thin wall ( ≤ 4 mm) along the lesion circumference [7][8][9][10]. In addition, there is not nodular lesion observed at or near the cavity wall except one patient.…”

Childhood intrathoracic Hodgkin lymphoma with hypertrophic pulmonary osteoarthropathy: a case report and review of the literature

“…Five of the nine patients were from Turkey, which in itself is remarkable as the peak incidence of HL in Turkey is before 10 years of age, and two thirds of the patients have mixed cellularity type of disease [5]. A review of 14 adult patients with HL and HOA revealed that only three had the nodular sclerosing type of the disease [3]. However, current data are insufficient to reveal an agedependent distribution of HL types in patients with associated HOA.…”