Comparative study of solitary thin-walled cavity lung cancer with computed tomography and pathological findings

Xue, Xinying; Wang, Pei-lan; Xue, Qingliang; Wang, Na; Zhang, Lina; Sun, Jia; Wang, KaiFei; Yang, Bing; Wang, Jianxin

doi:10.1016/j.lungcan.2012.06.004

Cited by 47 publications

(49 citation statements)

References 12 publications

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“…Among these cases, four had moderately differentiated adenocarcinoma, five had highly differentiated adenocarcinoma accompanied by bronchial alveolar carcinoma, one had slightly differentiated adenocarcinoma accompanied by neuroendocrine carcinoma, two had mixed-type adenocarcinoma (bronchial alveolar carcinoma and alveolar-type adenocarcinoma) with visceral pleura involvement and four had highly differentiated adenocarcinomas. These results are consistent with the study by Xue et al (15). Liu (16) also reported 25 cases of thin-walled cavity lung cancer.…”

Section: Discussionsupporting

confidence: 94%

“…The partial-cavity patients exhibited thick cavity walls and presented with lymph node or organ metastasis. These CT observations are consistent with the malignant manifestations of thin-walled cavity lung cancer that have previously been observed (15) and are important signs for diagnosing this type of lung cancer. In the current study, the cavity wall of partial-cavity patients was thick and formed local nodules.…”

Section: Discussionsupporting

confidence: 90%

“…Xue et al (15) reported that 18 cases of thin-walled cavity lung cancer were adenocarcinomas and in the present study, all 16 cases were adenocarcinomas. Among these cases, four had moderately differentiated adenocarcinoma, five had highly differentiated adenocarcinoma accompanied by bronchial alveolar carcinoma, one had slightly differentiated adenocarcinoma accompanied by neuroendocrine carcinoma, two had mixed-type adenocarcinoma (bronchial alveolar carcinoma and alveolar-type adenocarcinoma) with visceral pleura involvement and four had highly differentiated adenocarcinomas.…”

Section: Discussionsupporting

confidence: 61%

“…The tumors in the current study occurred in the periphery of the lungs. By contrast, Xue et al (15) described a different distribution pattern in 18 cases of cavity-type lung cancer. Given that the sample size of the current study is small, further studies are required to investigate whether the incidence rate is associated with gender and whether tumors primarily occur in the periphery of the lungs.…”

Section: Discussionmentioning

confidence: 94%

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Manifestations and pathological features of solitary thin-walled cavity lung cancer observed by CT and PET/CT imaging

Zhang

Huang

et al. 2014

Oncology Letters

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The aim of the present study was to analyze and improve the understanding of computed tomography (CT) and positron emission tomography (PET)/CT imaging and the pathological features of solitary thin-walled cavity lung cancer. A total of 16 patients with pathologically confirmed solitary thin-walled cavity lung cancer were included in the present study. All of the patients received CT scans. Among these, two patients underwent an additional PET/CT examination. The CT and PET/CT images were analyzed and a cross-check analysis of the pathological results was conducted. In total, 16 cases of lesions demonstrated thin-walled cavities on the CT images. Among these cases, three presented with an uneven thickening of the cavity walls, 10 cases exhibited wall nodules and three cases presented with compartments in the cavity. The standard uptake value (SUV) of the cavity wall increased in two patients who underwent PET/CT examinations. The 16 cases of lesions were pathologically confirmed as adenocarcinomas. Light microscopy revealed that the tumor cells, which were observed in 12 cases of lesions, had diffused along the inner cavity wall and the tumor cells of four cases had invaded the bronchial wall. Images of the chest that demonstrated a single thin-walled cavity accompanied by uneven thickening of the cavity wall or wall nodules, in addition to an increase in the SUV and compartments in the cavity, indicated potential lung cancer. Valves formed as a result of bronchial wall damage may have led to the cavity.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 94%

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Manifestations and pathological features of solitary thin-walled cavity lung cancer observed by CT and PET/CT imaging

Zhang

Huang

et al. 2014

Oncology Letters

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“…Vacuole refers to transparent light with a diameter of <5 mm and relatively low density, which is very common in lung cancer. Recent evidence suggests that vacuole features on CT are of significance for distinguishing lung cancer from benign lesions 18. Cavity formation occurs as diseased substances from lung necrosis and liquefaction are excreted through the bronchus.…”

Section: Discussionmentioning

confidence: 99%

Relationship between computed tomography morphology and prognosis of patients with stage I non-small cell lung cancer

Yang

Wang³

et al. 2017

OTT

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This study aimed to explore the relationship between computed tomography morphology and prognosis of patients with stage I non-small cell lung cancer (NSCLC). From May 2009 to May 2011, a total of 124 patients diagnosed with stage I NSCLC were included. All patients had complete chest computed tomography scans. Five-year follow-up was conducted. Univariate and multivariate Cox regression analyses were performed to estimate the prognostic factors for patients with stage I NSCLC. The 5-year survival rate was 67.74% (84/124). The 5-year survival rates of patients with stage T1a, T1b, and T2a were 89.19%, 75.00%, and 41.86%, respectively. The 5-year survival rates of patients with homogeneity, inhomogeneity, vacuole, and cavity were 68.42%, 72.09%, 59.46%, and 83.33%, respectively. The 5-year survival rates of patients with different margin features were 83.33% (slick margin), 79.73% (lobulation sign), and 39.47% (short burr). The 5-year survival rates of patients with normal, halo, vessel convergence, bronchial transection, and vascular bundle thickening were 84.38%, 72.73%, 71.79%, 52.00%, and 47.06%, respectively. The 5-year survival rates of patients with normal and pleura thickening/indentation were 81.93% and 39.02%. Univariate analysis demonstrated that tumor node metastasis staging, tumor margin, tumor periphery, and pleural invasion were related to the prognosis of stage I NSCLC patients. Cox regression analysis confirmed that T2a stage, pleura thickening/indentation were independent risk factors for poor prognosis of stage I NSCLC. In conclusion, our findings indicate that T2a stage, pleura thickening/indentation might be prognostic factors in stage I NSCLC.

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Multiple pulmonary Aspergillus fumigatus cysts and cavities that disappeared with anti‐fungal agents

Saitou

Suzuki

Niitsuma

2018

Respirology Case Reports

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A 26‐year‐old man with a 10‐year history of asthma was admitted to our hospital with a six‐week history of dry cough and slight fever. We observed the left pneumothorax with multiple cysts and cavities and performed partial cystectomy of the left upper lung. Y‐shaped mycelia were detected in the resected tissue, and Aspergillus fumigatus was cultured. Pulmonary aspergillosis was diagnosed from the histopathological and bacteriological findings, and the patient demonstrated positive immunological reactions to A. fumigatus. After administration of an intravenous antifungal agent for one month and an oral antifungal agent for another three months, all cysts and cavities disappeared. Aspergillus infection usually results from saprophytic growth within pre‐existing cavities. In this case, multiple cysts and cavities may have been caused by Aspergillus, possibly through a check‐valve mechanism.

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Comparative study of solitary thin-walled cavity lung cancer with computed tomography and pathological findings

Cited by 47 publications

References 12 publications

Manifestations and pathological features of solitary thin-walled cavity lung cancer observed by CT and PET/CT imaging

Manifestations and pathological features of solitary thin-walled cavity lung cancer observed by CT and PET/CT imaging

Relationship between computed tomography morphology and prognosis of patients with stage I non-small cell lung cancer

Multiple pulmonary Aspergillus fumigatus cysts and cavities that disappeared with anti‐fungal agents

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