Hypertrophic cardiomyopathy

Antunes, Murillo de Oliveira; Scudeler, Thiago Luis

doi:10.1016/j.ijcha.2020.100503

Cited by 39 publications

(42 citation statements)

References 120 publications

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“…Однако из-за мощного развития инновационных и более точных методов диагностики сердечно-сосудистых заболеваний может оказаться, что частота встречаемости ГКМП в общей популяции значительно выше, чем предполагалось ранее [3]. Недавно проведенные крупные исследования с длительным наблюдением показали, что ежегодная смертность составляет от 0,9-1,5% и снижается на 0,5% в год после разработки и внедрения новых методов терапии, таких как имплантируемый кардиовертер-дефибриллятор (ИКД) и трансплантация сердца [4]. Вариант клинического течения гипертрофической кардиомиопатии может варьировать от бессимптомного до злокачественного, в частности, внезапной сердечной смерти и прогрессирующей сердечной недостаточности, что заставляет искать все новые механизмы, лежащие в основе патофизиологии и в структуре измененного миокарда при гипертрофической кардиомиопатии.…”

Section: Endothelial Dysfunction and Myocardial Stress In Hypertrophic Cardyomyopathyunclassified

Assesment of Markers of Endothelial Dysfunction and Myocardial Stress in Patients with Hypertrophic Cardyomyopathy

Bogatyreva

Kaplunova

Kozhevnikova

et al. 2021

Racionalʹnaâ farmakoterapiâ v kardiologii

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Aim. To study the level of serum biomarkers of endothelial dysfunction and myocardial stress in patients with various types of hypertrophic cardiomyopathy (HCM).Material and Methods. 48 patients with hypertrophic cardiomyopathy (27 men and 21 women) were examined, the mean age was 54±13 years. The patients were divided into two groups according to the course options: group 1 - symptomatic stable course (n=14); group 2 - progressive course of symptomatic HCM (n=34). In accordance with the assigned tasks, all patients underwent determination of biological markers of neurohumoral systems in blood serum using immunofluorescence assay analysis: N-terminal fragment of brain natriuretic peptide (NT-proBNP), von Willebrand factor (vWF), endothelin-1, E-selectin with subsequent evaluation and correlation of results with clinical and instrumental characteristics of patients. When performing echocardiography following parameters were assessed: dimensions of the heart chambers, the thickness of the interventricular septum, the thickness of the posterior wall of the left ventricle (LV), LV mass, LV mass index, the ratio between LV filling in diastole (peak E) and atrial systole (peak A)-(E/A), relative myocardial thickness index, left atrial volume index.Results. Both groups showed increased levels of NT-proBNP and endothelin-1. E-selectin and vonWillebrand factor remained within the normal range. There was no statistically significant intergroup difference. There was a correlation between the level of the index of the relative myocardial thickness and the level of NT-proBNP (r=0.30; p=0.04). A correlation was found between the level of the vWF marker and the left atrial volume index (r=0.32; p=0.04). When assessing the association of indicators of intracardiac hemodynamics with other markers (E-selectin and endothelin-1, no statistically significant relationships were found.Conclusion. In the course of the research, it was found that the high activity of endothelin-1 and NT-proBNP reflects endothelial dysfunction and myocardial stress in patients with HCM, especially in patients with a progressive variant of HCM. However, we did not find any changes in the levels of E-selectin and von Willebrand factor, as well as their intergroup differences. These results require additional studies to assess endothelial dysfunction in patients with HCM.

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Section: Endothelial Dysfunction and Myocardial Stress In Hypertrophic Cardyomyopathyunclassified

Assesment of Markers of Endothelial Dysfunction and Myocardial Stress in Patients with Hypertrophic Cardyomyopathy

Bogatyreva

Kaplunova

Kozhevnikova

et al. 2021

Racionalʹnaâ farmakoterapiâ v kardiologii

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“…Cardiovascular diseases represent the main cause of death and disability in the Western world; in recent decades, there has been an increase in disorders caused by heart failure (HF). Several risk factors [ 1 , 2 , 3 , 4 , 5 ] contribute to the onset of HF that can be distinguished into non-modifiable, (sex, age, family predisposition, genetic factors, aging) [ 6 ], partially modifiable, (obesity, diabetes mellitus, hypercholesterolemia, arterial hypertension, increase in radical species, increase in systemic inflammatory processes) [ 7 , 8 , 9 ], and modifiable (alcohol and drug abuse, physical inactivity, high-calorie diet rich in saturated fat and salt) [ 10 , 11 , 12 , 13 , 14 ]. In addition, HF often occurs in patients with comorbidities such as diabetes, hypertension, and dyslipidemia [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Bergamot Polyphenols on Mitochondrial Dysfunction and Sarcoplasmic Reticulum Stress in Diabetic Cardiomyopathy

et al. 2021

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Cardiovascular disease is the leading cause of death and disability in the Western world. In order to safeguard the structure and the functionality of the myocardium, it is extremely important to adequately support the cardiomyocytes. Two cellular organelles of cardiomyocytes are essential for cell survival and to ensure proper functioning of the myocardium: mitochondria and the sarcoplasmic reticulum. Mitochondria are responsible for the energy metabolism of the myocardium, and regulate the processes that can lead to cell death. The sarcoplasmic reticulum preserves the physiological concentration of the calcium ion, and triggers processes to protect the structural and functional integrity of the proteins. The alterations of these organelles can damage myocardial functioning. A proper nutritional balance regarding the intake of macronutrients and micronutrients leads to a significant improvement in the symptoms and consequences of heart disease. In particular, the Mediterranean diet, characterized by a high consumption of plant-based foods, small quantities of red meat, and high quantities of olive oil, reduces and improves the pathological condition of patients with heart failure. In addition, nutritional support and nutraceutical supplementation in patients who develop heart failure can contribute to the protection of the failing myocardium. Since polyphenols have numerous beneficial properties, including anti-inflammatory and antioxidant properties, this review gathers what is known about the beneficial effects of polyphenol-rich bergamot fruit on the cardiovascular system. In particular, the role of bergamot polyphenols in mitochondrial and sarcoplasmic dysfunctions in diabetic cardiomyopathy is reported.

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“…These are complex heart muscle disorders compounded by genetic and environmental factors. Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) have an estimated prevalence of 1:500 and 1:250 in the general population [1, 2, 3, 4]. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is succeeding primary form with an estimated prevalence of one in 2000–5000 [5].…”

Section: Introductionmentioning

confidence: 99%

Integrative network analysis interweaves the missing links in cardiomyopathy diseasome

Sowdhamini

2021

Preprint

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Background: Cardiomyopathies are genetic disorders resulting in an abnormal heart phenotype due to intrinsic cardiac muscle malfunction, which leads to heart failure. These are chronic disorders contributing more than 36% of heart failure in the patients. Cardiomyopathies also show co-morbidity with other diseases that frequently affect the elderly. Apart from this, many drugs used for treating other unrelated diseases cause cardio-toxicity and lead to cardiomyopathies. Unravelling the cross-talk between them is essential for useful characterization, subtyping, and better treatment of the cardiomyopathies. Results: In this work, we applied a systems biology-based analysis to explore the associations between cardiomyopathies and other morbidities. For this, we built a cardiomyopathy disease-disease network based on the combine biological data relevant to cardiomyopathies. For this, we make use of publicly available genetic, non-coding, drug and PPI datasets related to cardiomyopathies and network science tools to identify new modifiers genes that may have a role in cardiomyopathies. These modifier genes are further enriched using mouse phenotype data. Lastly, we highlight key modifier genes that may be potentially associated with cardiomyopathies. Many predicted genes link cardiomyopathies to neoplasms, metabolic and neurological disorders; some of these have been explained as case studies in this analysis. Conclusions: Traditional one drug-one target-one disease outlook alone in drug discovery is inefficient. We hereby develop an integrative approach based on primary cardiomyopathy target genes to discover new targets that provide clues in drug re-purposing, possible off-targets and hidden genetic overlap between cardiomyopathies and other morbidities. We report potential modifier genes like NOTCH4, SIRT1 that may be investigated for role in cardiomyopathy and other diseases.

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Hypertrophic cardiomyopathy

Cited by 39 publications

References 120 publications

Assesment of Markers of Endothelial Dysfunction and Myocardial Stress in Patients with Hypertrophic Cardyomyopathy

Assesment of Markers of Endothelial Dysfunction and Myocardial Stress in Patients with Hypertrophic Cardyomyopathy

Effects of Bergamot Polyphenols on Mitochondrial Dysfunction and Sarcoplasmic Reticulum Stress in Diabetic Cardiomyopathy

Integrative network analysis interweaves the missing links in cardiomyopathy diseasome

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