Hypertriglyceridemia and Cardiovascular Outcomes

Malhotra, Gurveen; Sethi, Ankur; Arora, Rohit

doi:10.1097/mjt.0000000000000116

Cited by 6 publications

(4 citation statements)

References 58 publications

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“…Decreased lipoprotein lipase activity and increased levels of serum small dense LDL-particle are associated with lower HDL-C levels and higher TG levels [ 30 ]. Thus, the TG/HDL-C ratio may represent an easy-to-measure statistic for screening for TG metabolism abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Associations of non-HDL-C and triglyceride/HDL-C ratio with coronary plaque burden and plaque characteristics in young adults

Akın

Altun

Ayça³

et al. 2022

Bosn J of Basic Med Sci

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Coronary artery disease (CAD) is uncommon in young adult patients. However, these patients have different risk factor profiles and high-risk coronary plaques are more common. The aim of this study was to examine the relations between the coronary plaque burden, plaque composition, serum non-high-density lipoprotein cholesterol (non–HDL-C) levels, and triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio in young adults. We analyzed a total of 551 patients under age 45 who had undergone coronary computed tomography angiography (CCTA). Coronary plaque characteristics were analyzed using CCTA. Multivariate linear regression analysis was used to assess the predictors of non-calcified plaque (NCB) and calcified plaque (CB) burdens. Serum non–HDL-C levels and TG/HDL-C ratio were higher in the coronary atherosclerosis patient group. Serum non–HDL-C levels and the TG/HDL-C ratio were higher in the obstructive CAD patient group. The plaque burden was positively correlated with non-HDL-C (r = 0.30; p < 0.001), and TG/HDL-C ratio (r = 0.18; p < 0.001). NCB was positively correlated with age, gender, smoking status, fasting blood glucose, total cholesterol, low-density lipoprotein cholesterol, serum triglycerides, hbA1c, non–HDL-C, and TG/HDL-C ratio. Non–HDL-C (β coefficient = 0.13; p = 0.023) and TG/HDL-C ratio (β = 0.10; p = 0.042) were independent predictors of NCB. Serum non–HDL-C levels and TG/HDL-C were significantly associated with the presence and burden of coronary plaques. Serum non–HDL-C and TG/HDL-C ratios were independently associated with NCB, suggesting their use as easy-to-compute markers for identifying high-risk groups in young adults.

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Section: Discussionmentioning

confidence: 99%

Associations of non-HDL-C and triglyceride/HDL-C ratio with coronary plaque burden and plaque characteristics in young adults

Akın

Altun

Ayça³

et al. 2022

Bosn J of Basic Med Sci

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“…Although most studies show an increase in TG levels and cardiovascular risk, a few studies do not support this. 26,27 The TyG index, which is calculated from FPG and TG levels, may be more useful in predicting cardiovascular outcomes than evaluations of those 2 parameters separately.…”

Section: Discussionmentioning

confidence: 99%

High Triglyceride–Glucose Index is Associated With Poor Prognosis in Patients With Acute Coronary Syndrome in Long-Term Follow-Up

Karadeniz

Altuntas²,

Karadeniz

2022

Angiology

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The triglyceride-glucose (TyG) index is calculated from fasting triglycerides and fasting glucose levels and is an indicator of insulin resistance. The present study investigates whether the TyG index has a role in predicting clinical outcomes in cases of acute coronary syndrome (ACS). This retrospective study included 646 patients with ST-elevation myocardial infarction (STEMI) and 1048 patients with non–ST-elevation myocardial infarction (NSTEMI). The association between major adverse cardiac events (MACEs) that developed in-hospital and at 60 months of follow-up and TyG index values were compared. Patients were divided into 2 groups: TyG index values of ≥8.65 and <8.65. During the hospital stay and 60 months of follow-up, 303 MACEs occurred. In both the STEMI and NSTEMI groups, as the TyG index increased, an increase was observed in MACE rates. MACE rates were also found to be highest in the group with TyG index ≥8.65 ( P < .001). TyG index, C-reactive protein, and age were independent predictors of MACEs in both the NSTEMI and STEMI groups. The present study found a significant association between higher TyG index values and increased risk of MACEs in ACS patients. The TyG index may prove useful to predict clinical outcomes in ACS patients.

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“…Many large epidemiological studies have supported that triglycerides (TGs) correlate with CVD risk ( 15 – 17 ), although the association is sometimes attenuated with adjustment for other traditional risk factors ( 18 ). However, increasing evidence now has highlighted the importance of triglyceride-rich lipoproteins (TRLs) and their remnants, both in fasting and nonfasting periods ( 19 – 22 ).…”

Section: Introductionmentioning

confidence: 99%

Biomarker Discovery in Atherosclerotic Diseases Using Quantitative Nuclear Magnetic Resonance Metabolomics

Xia

Gao

2021

Front. Cardiovasc. Med.

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Despite great progress in the management of atherosclerosis (AS), its subsequent cardiovascular disease (CVD) remains the leading cause of morbidity and mortality. This is probably due to insufficient risk detection using routine lipid testing; thus, there is a need for more effective approaches relying on new biomarkers. Quantitative nuclear magnetic resonance (qNMR) metabolomics is able to phenotype holistic metabolic changes, with a unique advantage in regard to quantifying lipid-protein complexes. The rapidly increasing literature has indicated that qNMR-based lipoprotein particle number, particle size, lipid components, and some molecular metabolites can provide deeper insight into atherogenic diseases and could serve as novel promising determinants. Therefore, this article aims to offer an updated review of the qNMR biomarkers of AS and CVD found in epidemiological studies, with a special emphasis on lipoprotein-related parameters. As more researches are performed, we can envision more qNMR metabolite biomarkers being successfully translated into daily clinical practice to enhance the prevention, detection and intervention of atherosclerotic diseases.

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Hypertriglyceridemia and Cardiovascular Outcomes

Cited by 6 publications

References 58 publications

Associations of non-HDL-C and triglyceride/HDL-C ratio with coronary plaque burden and plaque characteristics in young adults

Associations of non-HDL-C and triglyceride/HDL-C ratio with coronary plaque burden and plaque characteristics in young adults

High Triglyceride–Glucose Index is Associated With Poor Prognosis in Patients With Acute Coronary Syndrome in Long-Term Follow-Up

Biomarker Discovery in Atherosclerotic Diseases Using Quantitative Nuclear Magnetic Resonance Metabolomics

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