The triglyceride-glucose (TyG) index is calculated from fasting triglycerides and fasting glucose levels and is an indicator of insulin resistance. The present study investigates whether the TyG index has a role in predicting clinical outcomes in cases of acute coronary syndrome (ACS). This retrospective study included 646 patients with ST-elevation myocardial infarction (STEMI) and 1048 patients with non–ST-elevation myocardial infarction (NSTEMI). The association between major adverse cardiac events (MACEs) that developed in-hospital and at 60 months of follow-up and TyG index values were compared. Patients were divided into 2 groups: TyG index values of ≥8.65 and <8.65. During the hospital stay and 60 months of follow-up, 303 MACEs occurred. In both the STEMI and NSTEMI groups, as the TyG index increased, an increase was observed in MACE rates. MACE rates were also found to be highest in the group with TyG index ≥8.65 ( P < .001). TyG index, C-reactive protein, and age were independent predictors of MACEs in both the NSTEMI and STEMI groups. The present study found a significant association between higher TyG index values and increased risk of MACEs in ACS patients. The TyG index may prove useful to predict clinical outcomes in ACS patients.
Background/Aim: The enlargement of left atrial volume index (LAVI) in diastolic dysfunction (DD) may predispose one to atrial fibrillation (AF) and is an important etiological reason for ischemic stroke (IS). The ratio of LAVI increase to left ventricular ejection fraction (LVEF) is a new parameter, and this work investigates the correlation between DD parameters, LAVI, LAVI/LVEF ratio, and AF in patients with sinus rhythm presenting with IS. Methods: Here, 108 consecutive individuals who were diagnosed with IS were included in the case-control study. The patients were divided into two groups: Those with AF events on rhythm Holters (AF group, n=57) and those without (control group, n=51). LAVI was calculated from the apical four- and two-chamber views before the mitral valve was opened. LVEF was calculated by Simpson's method. Results: The mean age of the AF group was 73.9 (6.3) years, and the control group was 72.1 (3.9) years. Hypertension, diabetes mellitus, glucose, HbA1c, CHA₂DS₂-VASc score, and previous stroke were higher in the AF group (P<0.05). LAVI (35.7 [25.3-38.2] vs 29.6 [27.7-30.9], P<0.001), the LAVI/LVEF ratio (0.7 [0.63-0.77] vs 0.5 [0.50-0.54], P<0.001), and the E/é ratio (14.6 [13.9-15.0] vs 10.7 [9.0-11.8], P<0.001) were higher in patients with AF. Multivariable analyses showed that LAVI (OR:7.985, 95%CI [2.586-4.767], P<0.001) and the LAVI/LVEF ratio (OR:0.010, 95% CI [0.000-0.007], P=0.015) were potential independent risk factors for AF events. A positive correlation was found between the CHA₂DS₂-VASc score and LAVI (P=0.032, r=0.407) and LAVI/LVEF ratio (P=0.041, r=0.253). Conclusion: We concluded that the increase in LAVI and LAVI/LVEF ratio increases the risk of IS by increasing the tendency to AF. These parameters are useful in predicting IS.
Introduction: Acute coronary syndrome is a fatal clinical manifestation of coronary artery disease. A newly defined index—Systemic Immune– Inflammation Index—has recently been reported to have prognostic value in patients with cardiovascular disease. This investigation was aimed at evaluating the systemic immune-inflammation index predictive value for in-hospital and 1-year follow-up clinical outcomes in elderly patients with acute coronary syndrome. Materials and method: We retrospectively enrolled 910 consecutive patients in the study. We divided the patients into two groups: young patients with acute coronary syndrome (Group 1) and elderly patients with acute coronary syndrome (Group 2). The patients were followed up on for one year. We compared the two groups’ systemic immune-inflammation index results, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio. Results: The neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammation index were significantly higher in Group 2. According to multivariate logistic regression analyses, systemic immuneinflammation index, and platelet-to-lymphocyte ratio (p < 0.001, and p = 0.013, respectively) emerged as independent predictors of in-hospital mortality in Group 2. Group 2 had significantly worse in-hospital mortality rates than those of Group 1. However, the groups’ long-term outcomes were similar. Conclusion: High systemic immune-inflammation index values were independently associated with an elevated risk of in-hospital mortality in Group 2. This investigation may be the first to demonstrate that this index is independently linked with in-hospital and long-term mortality in elderly acute coronary syndrome patients. It could be used as an easy, inexpensive, and practical predictor to identify high-risk elderly patients with acute coronary syndrome. Keywords: Acute Coronary Syndrome; Inflammation; Aged
Background It is known that a wide frontal QRS‐T(f[QRS‐T]) angle in the electrocardiography (ECG) is associated with poor cardiovascular outcomes. The Tp‐e (the interval from the peak to the end of the T wave) interval and Tp‐e/QTc ratio show the dispersion of repolarization, and increased levels lead to ventricular arrhythmogenesis in congenital channelopathies and coronary heart disease. In this study, we aimed to investigate the relationship between f(QRS‐T), Tp‐e interval, and Tp‐e/QTc ratio and SYNTAX score in stable coronary artery disease (SCAD) patients. Methods A total of 403 patients who performed coronary angiography for SCAD were included. The study population was divided into two groups based on the SYNTAX score. Group 1 included 248 patients (high SYNTAX score > 0), and group 2 included 155 patients (low SYNTAX score = 0). SYNTAX score was calculated using an online SYNTAX score calculator from the coronary angiography images of each patient. The f(QRS‐T) angle (QRS angle minus T angle) was calculated from the automated reports of the 12‐lead ECG device. Tp‐e interval and Tp‐e/QTc ratio and other electrocardiographic parameters were recorded. Results The mean SYNTAX score in group 1 was 8. F(QRS‐T) angle, Tp‐e duration, Tp‐e/QT, and Tp‐e/QTc were significantly higher in group 1 compared with group 2. In the multivariate regression analysis, F(QRS‐T) angle and Tp‐e duration were independent predictors for SYNTAX scores in SCAD patients. Conclusions Our study showed that Tp‐e interval, Tp‐e/QTc ratio, and f(QRS‐T) angle were increased in patients with higher SYNTAX scores in patients with SCAD patients.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.