Hypertonic Saline Dextran Improves Outcome After Hypothermic Circulatory Arrest: A Study in a Surviving Porcine Model

Kaakinen, Timo; Alaoja, Hanna; Heikkinen, Jouni; Dahlbacka, Sebastian; Laurila, Päivi; Kiviluoma, Kai; Salomäki, Timo; Hannu, Tuominen; Ohtonen, Pasi; Biancari, Fausto; Juvonen, Tatu

doi:10.1016/j.athoracsur.2005.07.017

Cited by 11 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One human study (LOE 6, fair/neutral) showed that a combination of a colloid and hypertonic saline (HS) reduced the required total fluid volume administered during the first 24 hours after ROSC, but did not examine outcomes . Three porcine studies (LOE 6, good and fair/neutral) using a VF CPA model (where VF is ventricular fibrillation), found that hypertonic‐hyperoncotic solutions administered shortly after ROSC provided neurologic and cardiac protection compared to normal saline …”

Section: Cardiovascular Supportmentioning

confidence: 99%

RECOVER evidence and knowledge gap analysis on veterinary CPR. Part 6: Post‐cardiac arrest care

Smarick¹,

Haskins

Boller

et al. 2012

J Vet Emergen Crit Care

View full text Add to dashboard Cite

Objective -To systematically examine the evidence for interventions after the return of spontaneous circulation (ROSC) on outcomes from veterinary cardiopulmonary resuscitation and to determine important knowledge gaps. Design -Standardized, systematic evaluation of the literature, categorization of relevant articles according to level of evidence and quality, and development of consensus on conclusions for application of the concepts to clinical post-cardiac arrest care. Setting -Academia, referral practice, and general practice. Results -Fifteen standardized clinical questions important for post-cardiac arrest care were asked and research articles relevant to answering these questions were identified through structured, explicit literature database searches. The majority of these articles report research in species other than dogs or cats or consisted of experimental work in canine cardiac arrest models. Outcome metrics reported in these studies widely varied and ranged from quantification of mechanistic endpoints, such as elaboration of reactive oxygen species, to survival, and functional neurologic outcome. Conclusions -Despite the near complete absence of clinical veterinary studies, the process allowed the formulation of statements for several postcardiac arrest treatments that were either supportive, such as mild therapeutic hypothermia or controlled reoxygenation, or neutral, such as for mannitol administration or seizure prophylaxis. Evidence grading allowed transparency in regards to the strength of these recommendations. Moreover, numerous knowledge gaps emerged that will allow generation of a road map for progress in veterinary post-cardiac arrest care.

show abstract

Section: Cardiovascular Supportmentioning

confidence: 99%

RECOVER evidence and knowledge gap analysis on veterinary CPR. Part 6: Post‐cardiac arrest care

Smarick¹,

Haskins

Boller

et al. 2012

J Vet Emergen Crit Care

View full text Add to dashboard Cite

show abstract

“…Особую проблему в плане профилактики неврологических осложнений представля ют реконструктивные операции на дуге аорты в условиях полной гипотермической остановки кровообращения, которые сопро вождаются развитием ишемии головного мозга с последующим ишемически реперфузионным повреждением. Все это ведет к потере целостности гематоэнцефалического барьера и выходу жидкости в ткани головного мозга [59]. Введение ГР на основе декстранов в дозе 4 мл/кг при экспериментальной полной глубо кой гипотермической остановке кровообращения (75 мин при температуре 18°С) способствовало лучшему восстановлению не врологических функций, снижению ВЧД и сохранению метабо лизма головного мозга в постперфузионном периоде [59].…”

Section: о б з о р ыunclassified

“…Все это ведет к потере целостности гематоэнцефалического барьера и выходу жидкости в ткани головного мозга [59]. Введение ГР на основе декстранов в дозе 4 мл/кг при экспериментальной полной глубо кой гипотермической остановке кровообращения (75 мин при температуре 18°С) способствовало лучшему восстановлению не врологических функций, снижению ВЧД и сохранению метабо лизма головного мозга в постперфузионном периоде [59]. Тем не менее вопрос об эффективности использования данной методи ки защиты головного мозга в клинической практике требует от дельного и более детального изучения.…”

Section: о б з о р ыunclassified

Use of Hypertonic Sodium Chloride Solution at Surgery under Extracorporeal Circulation

Ломиворотов¹,

Фоминский²,

Непомнящих³

2012

rmt

View full text Add to dashboard Cite

“…Thus, S100B differentially influences cytokine release and cytotoxicity from distinct brain cells while inhibiting neuroregeneration by suppressing hypothermia‐induced axonal outgrowth 55 . Hypertonic saline dextran has neuroprotective properties, and when combined with hypothermia, both neuroprotection and neurological recovery are enhanced following circulatory arrest 56 …”

Section: Enhancing Neuroprotection By Combining Hypothermia With Addimentioning

confidence: 99%

“…55 Hypertonic saline dextran has neuroprotective properties, and when combined with hypothermia, both neuroprotection and neurological recovery are enhanced following circulatory arrest. 56 Neuronal pentraxins (NPs) define a family of novel proteins, called "long pentraxins," that are exclusively expressed in central neurons, and are homologous to the C-reactive and acute-phase proteins in the immune system. They are neuroprotective against hypoxia-induced neuronal death.…”

Section: Enhancing Neuroprotection By Combining Hypothermia With Addimentioning

confidence: 99%

Combinatorial techniques for enhancing neuroprotection

Kuffler

2010

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Brain and spinal cord (CNS) trauma typically kill a number of neurons, but even more neurons are killed by secondary causes triggered by the initial trauma. Thus, a minor insult may rapidly cause the death of a vastly larger number of neurons and complete paralysis. The best mechanism for reducing the extent of neurological deficits is to minimize the number of neurons killed by post-trauma sequelae. Neuroprotection techniques take many diverse forms with a breadth too great for a short review. Therefore, this review focuses on the neuroprotection provided by hypothermia and a number of other neuroprotective techniques, when administered singly or in combination, because it is generally found that combinations of applications lead to significantly better neuroprotection than is achieved by any one alone. The combinatorial approach to neuroprotection holds great promise for enhancing the degree of neuroprotection following trauma, leading to maximum maintenance of neurological function.

show abstract

Hypertonic Saline Dextran Improves Outcome After Hypothermic Circulatory Arrest: A Study in a Surviving Porcine Model

Cited by 11 publications

References 22 publications

RECOVER evidence and knowledge gap analysis on veterinary CPR. Part 6: Post‐cardiac arrest care

RECOVER evidence and knowledge gap analysis on veterinary CPR. Part 6: Post‐cardiac arrest care

Use of Hypertonic Sodium Chloride Solution at Surgery under Extracorporeal Circulation

Combinatorial techniques for enhancing neuroprotection

Contact Info

Product

Resources

About