Hyperthyroidism as a latent complication of autologous hematopoietic stem cell transplantation

Abstract

Thyroid dysfunction after hematopoietic stem cell transplantation has been investigated in many studies. Most post-transplant thyroid disorders such as hypothyroidism are recognized as a late complication whilst hyperthyroidism is infrequent and transient, and usually happens early at the onset after transplant. Here, we report two rare hyperthyroid cases, developing more than 2 years after autologous stem cell transplant. We suggest that hyperthyroidism be alerted in the post-transplant care, and special attention be paid to any latent events.

Outcomes of Combined Bone Marrow Stimulation and Patch Augmentation for Massive Rotator Cuff Tears

“…35,54,58 The crimson duvet, namely bone marrow stimulation using microfracture, is a simple and easy technique that does not require any particular instruments and causes no additional complications. 35,54,58 Because of the uncontrolled potential risk of growth factors and stem cells such as metaplasia and carcinogenesis, 21,23,51 bone marrow stimulation has been getting much attention as a convincing and realistic surgical solution for biological augmentation. Jo et al 35 reported significant improvement in the postoperative retear rate compared with a control group at a minimum of 9 months after surgery (22.2% vs 45.2%, respectively).…”

Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells

“…Transient hyperthyroidism was usually nonsymptomatic, especially in auto-HSCT recipients, and did not require any treatment [26, 27, 90]. However, both transplanted patients with transient hyperthyroidism and those with evidence of thyroiditis and normal thyroid function for their risk of developing hypothyroidism should be monitored every 3 to 4 months after transplant until their endocrine parameters are normalized [107, 108]. Known risk factors for thyroid dysfunction are summarized in Table 3.…”

Cytomegalovirus reactivation triggers the late onset of hyperthyroidism after autologous peripheral blood transplantation

“…A previous study reported that the prevalence of subclinical hyperthyroidism within 3 months of auto-HSCT was 16% and all cases of subclinical hyperthyroidism had disappeared within 6 months [2] . However, clinical hyperthyroidism is a rare complication after transplantation, with few case reports being published in the literature [2] , [3] , [4] .…”

“…Feng et al. reported two hyperthyroid cases that developed more than 2 years after auto-HSCT [3] . In their cases, a pre-transplant assessment showed normal thyroid function; however, details on thyroid function after HSCT to the onset of hyperthyroidism were not shown.…”